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Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study
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| Zeitschriftentitel: | International Journal of Neuropsychopharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , |
| In: | International Journal of Neuropsychopharmacology, 22, 2019, 8, S. 513-522 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| author_facet |
Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert |
|---|---|
| author |
Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert |
| spellingShingle |
Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert International Journal of Neuropsychopharmacology Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study Pharmacology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
kraus, christoph |
| spelling |
Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert 1461-1457 1469-5111 Oxford University Press (OUP) Pharmacology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1093/ijnp/pyz030 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Studies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients with major depressive disorder yielded inconsistent results, and effects on hippocampal subfields are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To detail treatment effects on total hippocampal and subfield volumes, we conducted an open-label study with escitalopram followed by venlafaxine upon nonresponse in 20 unmedicated patients with major depressive disorder. Before and after 12 weeks treatment, we measured total hippocampal formation volumes and subfield volumes with ultra-high field (7 Tesla), T1-weighted, structural magnetic resonance imaging, and FreeSurfer. Twenty-eight remitted patients and 22 healthy subjects were included as controls. We hypothesized to detect increased volumes after treatment in major depressive disorder.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We did not detect treatment-related changes of total hippocampal or subfield volumes in patients with major depressive disorder. Secondary results indicated that the control group of untreated, stable remitted patients, compared with healthy controls, had larger volumes of the right hippocampal-amygdaloid transition area and right fissure at both measurement time points. Depressed patients exhibited larger volumes of the right subiculum compared with healthy controls at MRI-2. Exploratory data analyses indicated lower baseline volumes in the subgroup of remitting (n = 10) vs nonremitting (n = 10) acute patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results demonstrate that monoaminergic antidepressant treatment in major depressive disorder patients was not associated with volume changes in hippocampal subfields. Studies with larger sample sizes to detect smaller effects as well as other imaging modalities are needed to further assess the impact of antidepressant treatment on hippocampal subfields.</jats:p></jats:sec> Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study International Journal of Neuropsychopharmacology |
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| title |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_unstemmed |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_full |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_fullStr |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_full_unstemmed |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_short |
Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_sort |
hippocampal subfields in acute and remitted depression—an ultra-high field magnetic resonance imaging study |
| topic |
Pharmacology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1093/ijnp/pyz030 |
| publishDate |
2019 |
| physical |
513-522 |
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<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Studies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients with major depressive disorder yielded inconsistent results, and effects on hippocampal subfields are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To detail treatment effects on total hippocampal and subfield volumes, we conducted an open-label study with escitalopram followed by venlafaxine upon nonresponse in 20 unmedicated patients with major depressive disorder. Before and after 12 weeks treatment, we measured total hippocampal formation volumes and subfield volumes with ultra-high field (7 Tesla), T1-weighted, structural magnetic resonance imaging, and FreeSurfer. Twenty-eight remitted patients and 22 healthy subjects were included as controls. We hypothesized to detect increased volumes after treatment in major depressive disorder.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We did not detect treatment-related changes of total hippocampal or subfield volumes in patients with major depressive disorder. Secondary results indicated that the control group of untreated, stable remitted patients, compared with healthy controls, had larger volumes of the right hippocampal-amygdaloid transition area and right fissure at both measurement time points. Depressed patients exhibited larger volumes of the right subiculum compared with healthy controls at MRI-2. Exploratory data analyses indicated lower baseline volumes in the subgroup of remitting (n = 10) vs nonremitting (n = 10) acute patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results demonstrate that monoaminergic antidepressant treatment in major depressive disorder patients was not associated with volume changes in hippocampal subfields. Studies with larger sample sizes to detect smaller effects as well as other imaging modalities are needed to further assess the impact of antidepressant treatment on hippocampal subfields.</jats:p></jats:sec> |
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| author | Kraus, Christoph, Seiger, Rene, Pfabigan, Daniela M, Sladky, Ronald, Tik, Martin, Paul, Katharina, Woletz, Michael, Gryglewski, Gregor, Vanicek, Thomas, Komorowski, Arkadiusz, Kasper, Siegfried, Lamm, Claus, Windischberger, Christian, Lanzenberger, Rupert |
| author_facet | Kraus, Christoph, Seiger, Rene, Pfabigan, Daniela M, Sladky, Ronald, Tik, Martin, Paul, Katharina, Woletz, Michael, Gryglewski, Gregor, Vanicek, Thomas, Komorowski, Arkadiusz, Kasper, Siegfried, Lamm, Claus, Windischberger, Christian, Lanzenberger, Rupert, Kraus, Christoph, Seiger, Rene, Pfabigan, Daniela M, Sladky, Ronald, Tik, Martin, Paul, Katharina, Woletz, Michael, Gryglewski, Gregor, Vanicek, Thomas, Komorowski, Arkadiusz, Kasper, Siegfried, Lamm, Claus, Windischberger, Christian, Lanzenberger, Rupert |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Studies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients with major depressive disorder yielded inconsistent results, and effects on hippocampal subfields are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To detail treatment effects on total hippocampal and subfield volumes, we conducted an open-label study with escitalopram followed by venlafaxine upon nonresponse in 20 unmedicated patients with major depressive disorder. Before and after 12 weeks treatment, we measured total hippocampal formation volumes and subfield volumes with ultra-high field (7 Tesla), T1-weighted, structural magnetic resonance imaging, and FreeSurfer. Twenty-eight remitted patients and 22 healthy subjects were included as controls. We hypothesized to detect increased volumes after treatment in major depressive disorder.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We did not detect treatment-related changes of total hippocampal or subfield volumes in patients with major depressive disorder. Secondary results indicated that the control group of untreated, stable remitted patients, compared with healthy controls, had larger volumes of the right hippocampal-amygdaloid transition area and right fissure at both measurement time points. Depressed patients exhibited larger volumes of the right subiculum compared with healthy controls at MRI-2. Exploratory data analyses indicated lower baseline volumes in the subgroup of remitting (n = 10) vs nonremitting (n = 10) acute patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results demonstrate that monoaminergic antidepressant treatment in major depressive disorder patients was not associated with volume changes in hippocampal subfields. Studies with larger sample sizes to detect smaller effects as well as other imaging modalities are needed to further assess the impact of antidepressant treatment on hippocampal subfields.</jats:p></jats:sec> |
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| spelling | Kraus, Christoph Seiger, Rene Pfabigan, Daniela M Sladky, Ronald Tik, Martin Paul, Katharina Woletz, Michael Gryglewski, Gregor Vanicek, Thomas Komorowski, Arkadiusz Kasper, Siegfried Lamm, Claus Windischberger, Christian Lanzenberger, Rupert 1461-1457 1469-5111 Oxford University Press (OUP) Pharmacology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1093/ijnp/pyz030 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Studies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients with major depressive disorder yielded inconsistent results, and effects on hippocampal subfields are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To detail treatment effects on total hippocampal and subfield volumes, we conducted an open-label study with escitalopram followed by venlafaxine upon nonresponse in 20 unmedicated patients with major depressive disorder. Before and after 12 weeks treatment, we measured total hippocampal formation volumes and subfield volumes with ultra-high field (7 Tesla), T1-weighted, structural magnetic resonance imaging, and FreeSurfer. Twenty-eight remitted patients and 22 healthy subjects were included as controls. We hypothesized to detect increased volumes after treatment in major depressive disorder.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We did not detect treatment-related changes of total hippocampal or subfield volumes in patients with major depressive disorder. Secondary results indicated that the control group of untreated, stable remitted patients, compared with healthy controls, had larger volumes of the right hippocampal-amygdaloid transition area and right fissure at both measurement time points. Depressed patients exhibited larger volumes of the right subiculum compared with healthy controls at MRI-2. Exploratory data analyses indicated lower baseline volumes in the subgroup of remitting (n = 10) vs nonremitting (n = 10) acute patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results demonstrate that monoaminergic antidepressant treatment in major depressive disorder patients was not associated with volume changes in hippocampal subfields. Studies with larger sample sizes to detect smaller effects as well as other imaging modalities are needed to further assess the impact of antidepressant treatment on hippocampal subfields.</jats:p></jats:sec> Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study International Journal of Neuropsychopharmacology |
| spellingShingle | Kraus, Christoph, Seiger, Rene, Pfabigan, Daniela M, Sladky, Ronald, Tik, Martin, Paul, Katharina, Woletz, Michael, Gryglewski, Gregor, Vanicek, Thomas, Komorowski, Arkadiusz, Kasper, Siegfried, Lamm, Claus, Windischberger, Christian, Lanzenberger, Rupert, International Journal of Neuropsychopharmacology, Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study, Pharmacology (medical), Psychiatry and Mental health, Pharmacology |
| title | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_full | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_fullStr | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_full_unstemmed | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_short | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| title_sort | hippocampal subfields in acute and remitted depression—an ultra-high field magnetic resonance imaging study |
| title_unstemmed | Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study |
| topic | Pharmacology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1093/ijnp/pyz030 |