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Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy
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| Zeitschriftentitel: | Journal of Experimental Medicine |
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| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Journal of Experimental Medicine, 216, 2019, 5, S. 1154-1169 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
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| Schlagwörter: |
| author_facet |
Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia |
|---|---|
| author |
Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia |
| spellingShingle |
Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia Journal of Experimental Medicine Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy Immunology Immunology and Allergy |
| author_sort |
hong, seunghee |
| spelling |
Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20190185 <jats:p>Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4+ T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes.</jats:p> Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy Journal of Experimental Medicine |
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| title |
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
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Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_full |
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_fullStr |
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_full_unstemmed |
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_short |
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_sort |
longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| topic |
Immunology Immunology and Allergy |
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http://dx.doi.org/10.1084/jem.20190185 |
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2019 |
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1154-1169 |
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<jats:p>Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4+ T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes.</jats:p> |
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| author | Hong, Seunghee, Banchereau, Romain, Maslow, Bat-Sheva L., Guerra, Marta M., Cardenas, Jacob, Baisch, Jeanine, Branch, D. Ware, Porter, T. Flint, Sawitzke, Allen, Laskin, Carl A., Buyon, Jill P., Merrill, Joan, Sammaritano, Lisa R., Petri, Michelle, Gatewood, Elizabeth, Cepika, Alma-Martina, Ohouo, Marina, Obermoser, Gerlinde, Anguiano, Esperanza, Kim, Tae Whan, Nulsen, John, Nehar-Belaid, Djamel, Blankenship, Derek, Turner, Jacob, Banchereau, Jacques, Salmon, Jane E., Pascual, Virginia |
| author_facet | Hong, Seunghee, Banchereau, Romain, Maslow, Bat-Sheva L., Guerra, Marta M., Cardenas, Jacob, Baisch, Jeanine, Branch, D. Ware, Porter, T. Flint, Sawitzke, Allen, Laskin, Carl A., Buyon, Jill P., Merrill, Joan, Sammaritano, Lisa R., Petri, Michelle, Gatewood, Elizabeth, Cepika, Alma-Martina, Ohouo, Marina, Obermoser, Gerlinde, Anguiano, Esperanza, Kim, Tae Whan, Nulsen, John, Nehar-Belaid, Djamel, Blankenship, Derek, Turner, Jacob, Banchereau, Jacques, Salmon, Jane E., Pascual, Virginia, Hong, Seunghee, Banchereau, Romain, Maslow, Bat-Sheva L., Guerra, Marta M., Cardenas, Jacob, Baisch, Jeanine, Branch, D. Ware, Porter, T. Flint, Sawitzke, Allen, Laskin, Carl A., Buyon, Jill P., Merrill, Joan, Sammaritano, Lisa R., Petri, Michelle, Gatewood, Elizabeth, Cepika, Alma-Martina, Ohouo, Marina, Obermoser, Gerlinde, Anguiano, Esperanza, Kim, Tae Whan, Nulsen, John, Nehar-Belaid, Djamel, Blankenship, Derek, Turner, Jacob, Banchereau, Jacques, Salmon, Jane E., Pascual, Virginia |
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| description | <jats:p>Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4+ T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes.</jats:p> |
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| spelling | Hong, Seunghee Banchereau, Romain Maslow, Bat-Sheva L. Guerra, Marta M. Cardenas, Jacob Baisch, Jeanine Branch, D. Ware Porter, T. Flint Sawitzke, Allen Laskin, Carl A. Buyon, Jill P. Merrill, Joan Sammaritano, Lisa R. Petri, Michelle Gatewood, Elizabeth Cepika, Alma-Martina Ohouo, Marina Obermoser, Gerlinde Anguiano, Esperanza Kim, Tae Whan Nulsen, John Nehar-Belaid, Djamel Blankenship, Derek Turner, Jacob Banchereau, Jacques Salmon, Jane E. Pascual, Virginia 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20190185 <jats:p>Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Sustained down-regulation of multiple immune signatures, including interferon and plasma cells, was observed during healthy pregnancy. These changes appeared early after embryo implantation and were mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early up-regulation of neutrophil signatures that correlated with expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as activated CD4+ T cell counts. Thus, blood immunomonitoring reveals that both healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and a lack thereof associates with adverse outcomes.</jats:p> Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy Journal of Experimental Medicine |
| spellingShingle | Hong, Seunghee, Banchereau, Romain, Maslow, Bat-Sheva L., Guerra, Marta M., Cardenas, Jacob, Baisch, Jeanine, Branch, D. Ware, Porter, T. Flint, Sawitzke, Allen, Laskin, Carl A., Buyon, Jill P., Merrill, Joan, Sammaritano, Lisa R., Petri, Michelle, Gatewood, Elizabeth, Cepika, Alma-Martina, Ohouo, Marina, Obermoser, Gerlinde, Anguiano, Esperanza, Kim, Tae Whan, Nulsen, John, Nehar-Belaid, Djamel, Blankenship, Derek, Turner, Jacob, Banchereau, Jacques, Salmon, Jane E., Pascual, Virginia, Journal of Experimental Medicine, Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy, Immunology, Immunology and Allergy |
| title | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_full | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_fullStr | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_full_unstemmed | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_short | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_sort | longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| title_unstemmed | Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.20190185 |