Eintrag weiter verarbeiten
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
Gespeichert in:
| Zeitschriftentitel: | The Journal of Experimental Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | The Journal of Experimental Medicine, 204, 2007, 6, S. 1441-1451 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg |
|---|---|
| author |
Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg |
| spellingShingle |
Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg The Journal of Experimental Medicine Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells Immunology Immunology and Allergy |
| author_sort |
stary, georg |
| spelling |
Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20070021 <jats:p>Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but the exact mechanisms by which this compound induces tumor regression are not yet understood. While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, by immunohistochemistry, sizable numbers of both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within the inflammatory infiltrate. Surprisingly, peritumoral mDCs stained positive for perforin and granzyme B, whereas infiltrating pDCs expressed tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). The biological relevance of this observation can be deduced from our further findings that peripheral blood–derived CD11c+ mDCs acquired antiperforin and anti–granzyme B reactivity upon TLR7/8 stimulation and could use these molecules to effectively lyse major histocompatibility complex (MHC) class Ilo cancer cell lines. The same activation protocol led pDCs to kill MHC class I–bearing Jurkat cells in a TRAIL-dependent fashion. While suggesting that mDCs and pDCs are directly involved in the IMQ-induced destruction of BCC lesions, our data also add a new facet to the functional spectrum of DCs, ascribing to them a major role not only in the initiation but also in the effector phase of the immune response.</jats:p> Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells The Journal of Experimental Medicine |
| doi_str_mv |
10.1084/jem.20070021 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNzAwMjE |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNzAwMjE |
| institution |
DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Rockefeller University Press, 2007 |
| imprint_str_mv |
Rockefeller University Press, 2007 |
| issn |
1540-9538 0022-1007 |
| issn_str_mv |
1540-9538 0022-1007 |
| language |
English |
| mega_collection |
Rockefeller University Press (CrossRef) |
| match_str |
stary2007tumoricidalactivityoftlr78activatedinflammatorydendriticcells |
| publishDateSort |
2007 |
| publisher |
Rockefeller University Press |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Experimental Medicine |
| source_id |
49 |
| title |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_unstemmed |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_full |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_fullStr |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_full_unstemmed |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_short |
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_sort |
tumoricidal activity of tlr7/8-activated inflammatory dendritic cells |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.20070021 |
| publishDate |
2007 |
| physical |
1441-1451 |
| description |
<jats:p>Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but the exact mechanisms by which this compound induces tumor regression are not yet understood. While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, by immunohistochemistry, sizable numbers of both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within the inflammatory infiltrate. Surprisingly, peritumoral mDCs stained positive for perforin and granzyme B, whereas infiltrating pDCs expressed tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). The biological relevance of this observation can be deduced from our further findings that peripheral blood–derived CD11c+ mDCs acquired antiperforin and anti–granzyme B reactivity upon TLR7/8 stimulation and could use these molecules to effectively lyse major histocompatibility complex (MHC) class Ilo cancer cell lines. The same activation protocol led pDCs to kill MHC class I–bearing Jurkat cells in a TRAIL-dependent fashion. While suggesting that mDCs and pDCs are directly involved in the IMQ-induced destruction of BCC lesions, our data also add a new facet to the functional spectrum of DCs, ascribing to them a major role not only in the initiation but also in the effector phase of the immune response.</jats:p> |
| container_issue |
6 |
| container_start_page |
1441 |
| container_title |
The Journal of Experimental Medicine |
| container_volume |
204 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348184317526024 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:06:42.028Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Tumoricidal+activity+of+TLR7%2F8-activated+inflammatory+dendritic+cells&rft.date=2007-06-11&genre=article&issn=0022-1007&volume=204&issue=6&spage=1441&epage=1451&pages=1441-1451&jtitle=The+Journal+of+Experimental+Medicine&atitle=Tumoricidal+activity+of+TLR7%2F8-activated+inflammatory+dendritic+cells&aulast=Stingl&aufirst=Georg&rft_id=info%3Adoi%2F10.1084%2Fjem.20070021&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348184317526024 |
| author | Stary, Georg, Bangert, Christine, Tauber, Martina, Strohal, Robert, Kopp, Tamara, Stingl, Georg |
| author_facet | Stary, Georg, Bangert, Christine, Tauber, Martina, Strohal, Robert, Kopp, Tamara, Stingl, Georg, Stary, Georg, Bangert, Christine, Tauber, Martina, Strohal, Robert, Kopp, Tamara, Stingl, Georg |
| author_sort | stary, georg |
| container_issue | 6 |
| container_start_page | 1441 |
| container_title | The Journal of Experimental Medicine |
| container_volume | 204 |
| description | <jats:p>Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but the exact mechanisms by which this compound induces tumor regression are not yet understood. While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, by immunohistochemistry, sizable numbers of both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within the inflammatory infiltrate. Surprisingly, peritumoral mDCs stained positive for perforin and granzyme B, whereas infiltrating pDCs expressed tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). The biological relevance of this observation can be deduced from our further findings that peripheral blood–derived CD11c+ mDCs acquired antiperforin and anti–granzyme B reactivity upon TLR7/8 stimulation and could use these molecules to effectively lyse major histocompatibility complex (MHC) class Ilo cancer cell lines. The same activation protocol led pDCs to kill MHC class I–bearing Jurkat cells in a TRAIL-dependent fashion. While suggesting that mDCs and pDCs are directly involved in the IMQ-induced destruction of BCC lesions, our data also add a new facet to the functional spectrum of DCs, ascribing to them a major role not only in the initiation but also in the effector phase of the immune response.</jats:p> |
| doi_str_mv | 10.1084/jem.20070021 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNzAwMjE |
| imprint | Rockefeller University Press, 2007 |
| imprint_str_mv | Rockefeller University Press, 2007 |
| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1540-9538, 0022-1007 |
| issn_str_mv | 1540-9538, 0022-1007 |
| language | English |
| last_indexed | 2024-03-01T18:06:42.028Z |
| match_str | stary2007tumoricidalactivityoftlr78activatedinflammatorydendriticcells |
| mega_collection | Rockefeller University Press (CrossRef) |
| physical | 1441-1451 |
| publishDate | 2007 |
| publishDateSort | 2007 |
| publisher | Rockefeller University Press |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Experimental Medicine |
| source_id | 49 |
| spelling | Stary, Georg Bangert, Christine Tauber, Martina Strohal, Robert Kopp, Tamara Stingl, Georg 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20070021 <jats:p>Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but the exact mechanisms by which this compound induces tumor regression are not yet understood. While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, by immunohistochemistry, sizable numbers of both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within the inflammatory infiltrate. Surprisingly, peritumoral mDCs stained positive for perforin and granzyme B, whereas infiltrating pDCs expressed tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). The biological relevance of this observation can be deduced from our further findings that peripheral blood–derived CD11c+ mDCs acquired antiperforin and anti–granzyme B reactivity upon TLR7/8 stimulation and could use these molecules to effectively lyse major histocompatibility complex (MHC) class Ilo cancer cell lines. The same activation protocol led pDCs to kill MHC class I–bearing Jurkat cells in a TRAIL-dependent fashion. While suggesting that mDCs and pDCs are directly involved in the IMQ-induced destruction of BCC lesions, our data also add a new facet to the functional spectrum of DCs, ascribing to them a major role not only in the initiation but also in the effector phase of the immune response.</jats:p> Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells The Journal of Experimental Medicine |
| spellingShingle | Stary, Georg, Bangert, Christine, Tauber, Martina, Strohal, Robert, Kopp, Tamara, Stingl, Georg, The Journal of Experimental Medicine, Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells, Immunology, Immunology and Allergy |
| title | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_full | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_fullStr | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_full_unstemmed | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_short | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| title_sort | tumoricidal activity of tlr7/8-activated inflammatory dendritic cells |
| title_unstemmed | Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.20070021 |