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Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.
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| Zeitschriftentitel: | The Journal of experimental medicine |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of experimental medicine, 175, 1992, 1, S. 211-216 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
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| Schlagwörter: |
| author_facet |
Yin, T G Schendel, P Yang, Y C Yin, T G Schendel, P Yang, Y C |
|---|---|
| author |
Yin, T G Schendel, P Yang, Y C |
| spellingShingle |
Yin, T G Schendel, P Yang, Y C The Journal of experimental medicine Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. Immunology Immunology and Allergy |
| author_sort |
yin, t g |
| spelling |
Yin, T G Schendel, P Yang, Y C 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.175.1.211 <jats:p>The availability of large quantities of highly purified recombinant interleukin 11 (rhuIL-11) has allowed us to investigate the effects of rhuIL-11 on sheep red blood cell (SRBC)-specific antibody responses in the murine system. The results showed that rhuIL-11 was effective in enhancing the generation of mouse spleen SRBC-specific plaque-forming cells (PFC) in the in vitro cell culture system in a dose-dependent manner. These effects of rhuIL-11 were abrogated completely by the addition of anti-rhuIL-11 antibody, but not by the addition of preimmunized rabbit serum. Cell-depletion studies revealed that L3T4 (CD4)+ T cells, but not Lyt-2 (CD8)+ T cells, are required in the rhuIL-11-stimulated augmentation of SRBC-specific antibody responses. The effects of rhuIL-11 on the SRBC-specific antibody responses in vivo were also examined. RhuIL-11 administration to normal C3H/HeJ mice resulted in a dose-dependent increase in the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer in both the primary and secondary immune responses. In mice immunosuppressed by cyclophosphamide treatment, rhuIL-11 administration significantly augmented the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer when compared with the cyclophosphamide-treated mice without IL-11 treatment. These results demonstrated that IL-11 is a novel cytokine involved in modulating antigen-specific antibody responses in vitro as well as in vivo.</jats:p> Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. The Journal of experimental medicine |
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1992 |
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| title |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_unstemmed |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_full |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_fullStr |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_full_unstemmed |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_short |
Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_sort |
enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.175.1.211 |
| publishDate |
1992 |
| physical |
211-216 |
| description |
<jats:p>The availability of large quantities of highly purified recombinant interleukin 11 (rhuIL-11) has allowed us to investigate the effects of rhuIL-11 on sheep red blood cell (SRBC)-specific antibody responses in the murine system. The results showed that rhuIL-11 was effective in enhancing the generation of mouse spleen SRBC-specific plaque-forming cells (PFC) in the in vitro cell culture system in a dose-dependent manner. These effects of rhuIL-11 were abrogated completely by the addition of anti-rhuIL-11 antibody, but not by the addition of preimmunized rabbit serum. Cell-depletion studies revealed that L3T4 (CD4)+ T cells, but not Lyt-2 (CD8)+ T cells, are required in the rhuIL-11-stimulated augmentation of SRBC-specific antibody responses. The effects of rhuIL-11 on the SRBC-specific antibody responses in vivo were also examined. RhuIL-11 administration to normal C3H/HeJ mice resulted in a dose-dependent increase in the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer in both the primary and secondary immune responses. In mice immunosuppressed by cyclophosphamide treatment, rhuIL-11 administration significantly augmented the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer when compared with the cyclophosphamide-treated mice without IL-11 treatment. These results demonstrated that IL-11 is a novel cytokine involved in modulating antigen-specific antibody responses in vitro as well as in vivo.</jats:p> |
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| description | <jats:p>The availability of large quantities of highly purified recombinant interleukin 11 (rhuIL-11) has allowed us to investigate the effects of rhuIL-11 on sheep red blood cell (SRBC)-specific antibody responses in the murine system. The results showed that rhuIL-11 was effective in enhancing the generation of mouse spleen SRBC-specific plaque-forming cells (PFC) in the in vitro cell culture system in a dose-dependent manner. These effects of rhuIL-11 were abrogated completely by the addition of anti-rhuIL-11 antibody, but not by the addition of preimmunized rabbit serum. Cell-depletion studies revealed that L3T4 (CD4)+ T cells, but not Lyt-2 (CD8)+ T cells, are required in the rhuIL-11-stimulated augmentation of SRBC-specific antibody responses. The effects of rhuIL-11 on the SRBC-specific antibody responses in vivo were also examined. RhuIL-11 administration to normal C3H/HeJ mice resulted in a dose-dependent increase in the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer in both the primary and secondary immune responses. In mice immunosuppressed by cyclophosphamide treatment, rhuIL-11 administration significantly augmented the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer when compared with the cyclophosphamide-treated mice without IL-11 treatment. These results demonstrated that IL-11 is a novel cytokine involved in modulating antigen-specific antibody responses in vitro as well as in vivo.</jats:p> |
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| imprint_str_mv | Rockefeller University Press, 1992 |
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| spelling | Yin, T G Schendel, P Yang, Y C 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.175.1.211 <jats:p>The availability of large quantities of highly purified recombinant interleukin 11 (rhuIL-11) has allowed us to investigate the effects of rhuIL-11 on sheep red blood cell (SRBC)-specific antibody responses in the murine system. The results showed that rhuIL-11 was effective in enhancing the generation of mouse spleen SRBC-specific plaque-forming cells (PFC) in the in vitro cell culture system in a dose-dependent manner. These effects of rhuIL-11 were abrogated completely by the addition of anti-rhuIL-11 antibody, but not by the addition of preimmunized rabbit serum. Cell-depletion studies revealed that L3T4 (CD4)+ T cells, but not Lyt-2 (CD8)+ T cells, are required in the rhuIL-11-stimulated augmentation of SRBC-specific antibody responses. The effects of rhuIL-11 on the SRBC-specific antibody responses in vivo were also examined. RhuIL-11 administration to normal C3H/HeJ mice resulted in a dose-dependent increase in the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer in both the primary and secondary immune responses. In mice immunosuppressed by cyclophosphamide treatment, rhuIL-11 administration significantly augmented the number of spleen SRBC-specific PFC as well as serum SRBC-specific antibody titer when compared with the cyclophosphamide-treated mice without IL-11 treatment. These results demonstrated that IL-11 is a novel cytokine involved in modulating antigen-specific antibody responses in vitro as well as in vivo.</jats:p> Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. The Journal of experimental medicine |
| spellingShingle | Yin, T G, Schendel, P, Yang, Y C, The Journal of experimental medicine, Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11., Immunology, Immunology and Allergy |
| title | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_full | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_fullStr | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_full_unstemmed | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_short | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_sort | enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| title_unstemmed | Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.175.1.211 |