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Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.
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| Zeitschriftentitel: | The Journal of experimental medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | The Journal of experimental medicine, 174, 1991, 3, S. 625-631 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M |
|---|---|
| author |
Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M |
| spellingShingle |
Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M The Journal of experimental medicine Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. Immunology Immunology and Allergy |
| author_sort |
freeman, g j |
| spelling |
Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.174.3.625 <jats:p>Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and gamma interferon treated monocytes, has been shown to deliver such a costimulatory signal upon attachment to its ligand on T cells, CD28. We have cloned and sequenced the murine homologue of the human B7 gene. The predicted murine protein has 44% amino acid identity with human B7. The greatest similarity is in the Ig-V and Ig-C like domains. Murine B7 mRNA was detected in murine hematopoietic cells of B cell but not T cell origin. Cells transfected with murine B7 provided a costimulatory signal to human CD28+ T lymphocytes. These results demonstrate the costimulatory activity of murine B7 and provide evidence that the ligand attachment site is conserved between the two species.</jats:p> Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. The Journal of experimental medicine |
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Rockefeller University Press, 1991 |
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Rockefeller University Press, 1991 |
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0022-1007 1540-9538 |
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1991 |
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| title |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_unstemmed |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_full |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_fullStr |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_full_unstemmed |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_short |
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_sort |
structure, expression, and t cell costimulatory activity of the murine homologue of the human b lymphocyte activation antigen b7. |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.174.3.625 |
| publishDate |
1991 |
| physical |
625-631 |
| description |
<jats:p>Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and gamma interferon treated monocytes, has been shown to deliver such a costimulatory signal upon attachment to its ligand on T cells, CD28. We have cloned and sequenced the murine homologue of the human B7 gene. The predicted murine protein has 44% amino acid identity with human B7. The greatest similarity is in the Ig-V and Ig-C like domains. Murine B7 mRNA was detected in murine hematopoietic cells of B cell but not T cell origin. Cells transfected with murine B7 provided a costimulatory signal to human CD28+ T lymphocytes. These results demonstrate the costimulatory activity of murine B7 and provide evidence that the ligand attachment site is conserved between the two species.</jats:p> |
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| author | Freeman, G J, Gray, G S, Gimmi, C D, Lombard, D B, Zhou, L J, White, M, Fingeroth, J D, Gribben, J G, Nadler, L M |
| author_facet | Freeman, G J, Gray, G S, Gimmi, C D, Lombard, D B, Zhou, L J, White, M, Fingeroth, J D, Gribben, J G, Nadler, L M, Freeman, G J, Gray, G S, Gimmi, C D, Lombard, D B, Zhou, L J, White, M, Fingeroth, J D, Gribben, J G, Nadler, L M |
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| description | <jats:p>Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and gamma interferon treated monocytes, has been shown to deliver such a costimulatory signal upon attachment to its ligand on T cells, CD28. We have cloned and sequenced the murine homologue of the human B7 gene. The predicted murine protein has 44% amino acid identity with human B7. The greatest similarity is in the Ig-V and Ig-C like domains. Murine B7 mRNA was detected in murine hematopoietic cells of B cell but not T cell origin. Cells transfected with murine B7 provided a costimulatory signal to human CD28+ T lymphocytes. These results demonstrate the costimulatory activity of murine B7 and provide evidence that the ligand attachment site is conserved between the two species.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTc0LjMuNjI1 |
| imprint | Rockefeller University Press, 1991 |
| imprint_str_mv | Rockefeller University Press, 1991 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Freeman, G J Gray, G S Gimmi, C D Lombard, D B Zhou, L J White, M Fingeroth, J D Gribben, J G Nadler, L M 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.174.3.625 <jats:p>Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and gamma interferon treated monocytes, has been shown to deliver such a costimulatory signal upon attachment to its ligand on T cells, CD28. We have cloned and sequenced the murine homologue of the human B7 gene. The predicted murine protein has 44% amino acid identity with human B7. The greatest similarity is in the Ig-V and Ig-C like domains. Murine B7 mRNA was detected in murine hematopoietic cells of B cell but not T cell origin. Cells transfected with murine B7 provided a costimulatory signal to human CD28+ T lymphocytes. These results demonstrate the costimulatory activity of murine B7 and provide evidence that the ligand attachment site is conserved between the two species.</jats:p> Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. The Journal of experimental medicine |
| spellingShingle | Freeman, G J, Gray, G S, Gimmi, C D, Lombard, D B, Zhou, L J, White, M, Fingeroth, J D, Gribben, J G, Nadler, L M, The Journal of experimental medicine, Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7., Immunology, Immunology and Allergy |
| title | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_full | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_fullStr | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_full_unstemmed | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_short | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| title_sort | structure, expression, and t cell costimulatory activity of the murine homologue of the human b lymphocyte activation antigen b7. |
| title_unstemmed | Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.174.3.625 |