Eintrag weiter verarbeiten
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR
Gespeichert in:
| Zeitschriftentitel: | Journal of Cell Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Journal of Cell Biology, 203, 2013, 4, S. 575-583 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun |
|---|---|
| author |
Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun |
| spellingShingle |
Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun Journal of Cell Biology Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR Cell Biology |
| author_sort |
zhang, zhao |
| spelling |
Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun 1540-8140 0021-9525 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.201306012 <jats:p>The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (CiR/GliR) and activator (CiA/GliA) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which CiR/GliR properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro–Rpd3 complex plays a conserved role to function as a CiR corepressor.</jats:p> Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR Journal of Cell Biology |
| doi_str_mv |
10.1083/jcb.201306012 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4My9qY2IuMjAxMzA2MDEy |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4My9qY2IuMjAxMzA2MDEy |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Rockefeller University Press, 2013 |
| imprint_str_mv |
Rockefeller University Press, 2013 |
| issn |
1540-8140 0021-9525 |
| issn_str_mv |
1540-8140 0021-9525 |
| language |
English |
| mega_collection |
Rockefeller University Press (CrossRef) |
| match_str |
zhang2013atrophinrpd3complexrepresseshedgehogsignalingbyactingasacorepressorofcir |
| publishDateSort |
2013 |
| publisher |
Rockefeller University Press |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Cell Biology |
| source_id |
49 |
| title |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_unstemmed |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_full |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_fullStr |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_full_unstemmed |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_short |
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_sort |
atrophin–rpd3 complex represses hedgehog signaling by acting as a corepressor of cir |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1083/jcb.201306012 |
| publishDate |
2013 |
| physical |
575-583 |
| description |
<jats:p>The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (CiR/GliR) and activator (CiA/GliA) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which CiR/GliR properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro–Rpd3 complex plays a conserved role to function as a CiR corepressor.</jats:p> |
| container_issue |
4 |
| container_start_page |
575 |
| container_title |
Journal of Cell Biology |
| container_volume |
203 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337725130539009 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:20:53.011Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Atrophin%E2%80%93Rpd3+complex+represses+Hedgehog+signaling+by+acting+as+a+corepressor+of+CiR&rft.date=2013-11-25&genre=article&issn=0021-9525&volume=203&issue=4&spage=575&epage=583&pages=575-583&jtitle=Journal+of+Cell+Biology&atitle=Atrophin%E2%80%93Rpd3+complex+represses+Hedgehog+signaling+by+acting+as+a+corepressor+of+CiR&aulast=Zhao&aufirst=Yun&rft_id=info%3Adoi%2F10.1083%2Fjcb.201306012&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337725130539009 |
| author | Zhang, Zhao, Feng, Jing, Pan, Chenyu, Lv, Xiangdong, Wu, Wenqing, Zhou, Zhaocai, Liu, Feng, Zhang, Lei, Zhao, Yun |
| author_facet | Zhang, Zhao, Feng, Jing, Pan, Chenyu, Lv, Xiangdong, Wu, Wenqing, Zhou, Zhaocai, Liu, Feng, Zhang, Lei, Zhao, Yun, Zhang, Zhao, Feng, Jing, Pan, Chenyu, Lv, Xiangdong, Wu, Wenqing, Zhou, Zhaocai, Liu, Feng, Zhang, Lei, Zhao, Yun |
| author_sort | zhang, zhao |
| container_issue | 4 |
| container_start_page | 575 |
| container_title | Journal of Cell Biology |
| container_volume | 203 |
| description | <jats:p>The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (CiR/GliR) and activator (CiA/GliA) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which CiR/GliR properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro–Rpd3 complex plays a conserved role to function as a CiR corepressor.</jats:p> |
| doi_str_mv | 10.1083/jcb.201306012 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4My9qY2IuMjAxMzA2MDEy |
| imprint | Rockefeller University Press, 2013 |
| imprint_str_mv | Rockefeller University Press, 2013 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1540-8140, 0021-9525 |
| issn_str_mv | 1540-8140, 0021-9525 |
| language | English |
| last_indexed | 2024-03-01T15:20:53.011Z |
| match_str | zhang2013atrophinrpd3complexrepresseshedgehogsignalingbyactingasacorepressorofcir |
| mega_collection | Rockefeller University Press (CrossRef) |
| physical | 575-583 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Rockefeller University Press |
| record_format | ai |
| recordtype | ai |
| series | Journal of Cell Biology |
| source_id | 49 |
| spelling | Zhang, Zhao Feng, Jing Pan, Chenyu Lv, Xiangdong Wu, Wenqing Zhou, Zhaocai Liu, Feng Zhang, Lei Zhao, Yun 1540-8140 0021-9525 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.201306012 <jats:p>The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (CiR/GliR) and activator (CiA/GliA) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which CiR/GliR properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro–Rpd3 complex plays a conserved role to function as a CiR corepressor.</jats:p> Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR Journal of Cell Biology |
| spellingShingle | Zhang, Zhao, Feng, Jing, Pan, Chenyu, Lv, Xiangdong, Wu, Wenqing, Zhou, Zhaocai, Liu, Feng, Zhang, Lei, Zhao, Yun, Journal of Cell Biology, Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR, Cell Biology |
| title | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_full | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_fullStr | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_full_unstemmed | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_short | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| title_sort | atrophin–rpd3 complex represses hedgehog signaling by acting as a corepressor of cir |
| title_unstemmed | Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1083/jcb.201306012 |