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SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster
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| Zeitschriftentitel: | Journal of Cell Biology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Cell Biology, 188, 2010, 3, S. 335-349 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
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| Schlagwörter: |
| author_facet |
Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. |
|---|---|
| author |
Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. |
| spellingShingle |
Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. Journal of Cell Biology SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster Cell Biology |
| author_sort |
yan, rihui |
| spelling |
Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. 1540-8140 0021-9525 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.200904040 <jats:p>Sister chromatid cohesion is essential to maintain stable connections between homologues and sister chromatids during meiosis and to establish correct centromere orientation patterns on the meiosis I and II spindles. However, the meiotic cohesion apparatus in Drosophila melanogaster remains largely uncharacterized. We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in Drosophila. In solo mutants, sister centromeres separate before prometaphase I, disrupting meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids. Centromeric foci of the cohesin protein SMC1 are absent in solo mutants at all meiotic stages. SOLO and SMC1 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but both proteins disappear prematurely at anaphase I in mutants for mei-S332, which encodes the Drosophila homologue of the cohesin protector protein shugoshin. The solo mutant phenotypes and the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.</jats:p> SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in <i>Drosophila melanogaster</i> Journal of Cell Biology |
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| title |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_unstemmed |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_full |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_fullStr |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_full_unstemmed |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_short |
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_sort |
solo: a meiotic protein required for centromere cohesion, coorientation, and smc1 localization in <i>drosophila melanogaster</i> |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1083/jcb.200904040 |
| publishDate |
2010 |
| physical |
335-349 |
| description |
<jats:p>Sister chromatid cohesion is essential to maintain stable connections between homologues and sister chromatids during meiosis and to establish correct centromere orientation patterns on the meiosis I and II spindles. However, the meiotic cohesion apparatus in Drosophila melanogaster remains largely uncharacterized. We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in Drosophila. In solo mutants, sister centromeres separate before prometaphase I, disrupting meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids. Centromeric foci of the cohesin protein SMC1 are absent in solo mutants at all meiotic stages. SOLO and SMC1 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but both proteins disappear prematurely at anaphase I in mutants for mei-S332, which encodes the Drosophila homologue of the cohesin protector protein shugoshin. The solo mutant phenotypes and the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.</jats:p> |
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| author | Yan, Rihui, Thomas, Sharon E., Tsai, Jui-He, Yamada, Yukihiro, McKee, Bruce D. |
| author_facet | Yan, Rihui, Thomas, Sharon E., Tsai, Jui-He, Yamada, Yukihiro, McKee, Bruce D., Yan, Rihui, Thomas, Sharon E., Tsai, Jui-He, Yamada, Yukihiro, McKee, Bruce D. |
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| description | <jats:p>Sister chromatid cohesion is essential to maintain stable connections between homologues and sister chromatids during meiosis and to establish correct centromere orientation patterns on the meiosis I and II spindles. However, the meiotic cohesion apparatus in Drosophila melanogaster remains largely uncharacterized. We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in Drosophila. In solo mutants, sister centromeres separate before prometaphase I, disrupting meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids. Centromeric foci of the cohesin protein SMC1 are absent in solo mutants at all meiotic stages. SOLO and SMC1 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but both proteins disappear prematurely at anaphase I in mutants for mei-S332, which encodes the Drosophila homologue of the cohesin protector protein shugoshin. The solo mutant phenotypes and the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.</jats:p> |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
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| spelling | Yan, Rihui Thomas, Sharon E. Tsai, Jui-He Yamada, Yukihiro McKee, Bruce D. 1540-8140 0021-9525 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.200904040 <jats:p>Sister chromatid cohesion is essential to maintain stable connections between homologues and sister chromatids during meiosis and to establish correct centromere orientation patterns on the meiosis I and II spindles. However, the meiotic cohesion apparatus in Drosophila melanogaster remains largely uncharacterized. We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in Drosophila. In solo mutants, sister centromeres separate before prometaphase I, disrupting meiosis I centromere orientation and causing nondisjunction of both homologous and sister chromatids. Centromeric foci of the cohesin protein SMC1 are absent in solo mutants at all meiotic stages. SOLO and SMC1 colocalize to meiotic centromeres from early prophase I until anaphase II in wild-type males, but both proteins disappear prematurely at anaphase I in mutants for mei-S332, which encodes the Drosophila homologue of the cohesin protector protein shugoshin. The solo mutant phenotypes and the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.</jats:p> SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in <i>Drosophila melanogaster</i> Journal of Cell Biology |
| spellingShingle | Yan, Rihui, Thomas, Sharon E., Tsai, Jui-He, Yamada, Yukihiro, McKee, Bruce D., Journal of Cell Biology, SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster, Cell Biology |
| title | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_full | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_fullStr | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_full_unstemmed | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_short | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| title_sort | solo: a meiotic protein required for centromere cohesion, coorientation, and smc1 localization in <i>drosophila melanogaster</i> |
| title_unstemmed | SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1083/jcb.200904040 |