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Cell-specific accumulation of Drosophila proteasomes (MCP) during early development.
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| Zeitschriftentitel: | The Journal of cell biology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of cell biology, 111, 1990, 6, S. 2275-2282 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Klein, U Gernold, M Kloetzel, P M Klein, U Gernold, M Kloetzel, P M |
|---|---|
| author |
Klein, U Gernold, M Kloetzel, P M |
| spellingShingle |
Klein, U Gernold, M Kloetzel, P M The Journal of cell biology Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. Cell Biology |
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klein, u |
| spelling |
Klein, U Gernold, M Kloetzel, P M 0021-9525 1540-8140 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.111.6.2275 <jats:p>The proteasome (MCP) is a high relative molecular mass multicatalytic proteinase complex composed of nonidentical protein subunits. We have investigated the cellular distribution of the enzyme complex during Drosophila embryogenesis using the proteasome specific antibodies N19-35 and N19-28 for immunocytology. Antibody staining of whole-mount embryos shows that during embryogenesis proteasomes are present in proliferating cells and that their accumulation and turnover is differentially regulated. Our data suggest that the proteasome may serve different proteolytic processes and that the enzyme may be involved in cell-specific proteolytic events required for cell proliferation and morphogenesis during early Drosophila development.</jats:p> Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. The Journal of cell biology |
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Rockefeller University Press, 1990 |
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The Journal of cell biology |
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49 |
| title |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_unstemmed |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_full |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_fullStr |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_full_unstemmed |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_short |
Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_sort |
cell-specific accumulation of drosophila proteasomes (mcp) during early development. |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1083/jcb.111.6.2275 |
| publishDate |
1990 |
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2275-2282 |
| description |
<jats:p>The proteasome (MCP) is a high relative molecular mass multicatalytic proteinase complex composed of nonidentical protein subunits. We have investigated the cellular distribution of the enzyme complex during Drosophila embryogenesis using the proteasome specific antibodies N19-35 and N19-28 for immunocytology. Antibody staining of whole-mount embryos shows that during embryogenesis proteasomes are present in proliferating cells and that their accumulation and turnover is differentially regulated. Our data suggest that the proteasome may serve different proteolytic processes and that the enzyme may be involved in cell-specific proteolytic events required for cell proliferation and morphogenesis during early Drosophila development.</jats:p> |
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| author | Klein, U, Gernold, M, Kloetzel, P M |
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| description | <jats:p>The proteasome (MCP) is a high relative molecular mass multicatalytic proteinase complex composed of nonidentical protein subunits. We have investigated the cellular distribution of the enzyme complex during Drosophila embryogenesis using the proteasome specific antibodies N19-35 and N19-28 for immunocytology. Antibody staining of whole-mount embryos shows that during embryogenesis proteasomes are present in proliferating cells and that their accumulation and turnover is differentially regulated. Our data suggest that the proteasome may serve different proteolytic processes and that the enzyme may be involved in cell-specific proteolytic events required for cell proliferation and morphogenesis during early Drosophila development.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4My9qY2IuMTExLjYuMjI3NQ |
| imprint | Rockefeller University Press, 1990 |
| imprint_str_mv | Rockefeller University Press, 1990 |
| institution | DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| series | The Journal of cell biology |
| source_id | 49 |
| spelling | Klein, U Gernold, M Kloetzel, P M 0021-9525 1540-8140 Rockefeller University Press Cell Biology http://dx.doi.org/10.1083/jcb.111.6.2275 <jats:p>The proteasome (MCP) is a high relative molecular mass multicatalytic proteinase complex composed of nonidentical protein subunits. We have investigated the cellular distribution of the enzyme complex during Drosophila embryogenesis using the proteasome specific antibodies N19-35 and N19-28 for immunocytology. Antibody staining of whole-mount embryos shows that during embryogenesis proteasomes are present in proliferating cells and that their accumulation and turnover is differentially regulated. Our data suggest that the proteasome may serve different proteolytic processes and that the enzyme may be involved in cell-specific proteolytic events required for cell proliferation and morphogenesis during early Drosophila development.</jats:p> Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. The Journal of cell biology |
| spellingShingle | Klein, U, Gernold, M, Kloetzel, P M, The Journal of cell biology, Cell-specific accumulation of Drosophila proteasomes (MCP) during early development., Cell Biology |
| title | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_full | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_fullStr | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_full_unstemmed | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_short | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| title_sort | cell-specific accumulation of drosophila proteasomes (mcp) during early development. |
| title_unstemmed | Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1083/jcb.111.6.2275 |