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Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus
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| Zeitschriftentitel: | Journal of Extracellular Vesicles |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Journal of Extracellular Vesicles, 8, 2019, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu |
|---|---|
| author |
Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu |
| spellingShingle |
Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu Journal of Extracellular Vesicles Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus Cell Biology Histology |
| author_sort |
kandzija, neva |
| spelling |
Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu 2001-3078 2001-3078 Wiley Cell Biology Histology http://dx.doi.org/10.1080/20013078.2019.1617000 <jats:title>ABSTRACT</jats:title><jats:p>Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy and is characterized by insulin resistance and decreased circulating glucagon‐like peptide‐1 (GLP‐1). GDM resolves rapidly after delivery implicating the placenta in the disease. This study examines the biological functions that cause this pathology. The placenta releases syncytiotrophoblast‐derived extracellular vesicles (STB‐EVs) into the maternal circulation, which is enhanced in GDM. Dipeptidyl peptidase IV (DPPIV) is known to play a role in type 2 diabetes by breaking down GLP‐1, which in turn regulates glucose‐dependent insulin secretion. STB‐EVs from control and GDM women were analysed. We show that normal human placenta releases DPPIV‐positive STB‐EVs and that they are higher in uterine than paired peripheral blood, confirming placental origin. DPPIV‐bound STB‐EVs from normal perfused placentae are dose dependently inhibited with vildagliptin. DPPIV‐bound STB‐EVs from perfused placentae are able to breakdown GLP‐1 <jats:italic>in vitro</jats:italic>. STB‐EVs from GDM perfused placentae show greater DPPIV activity. Importantly, DPPIV‐bound STB‐EVs increase eightfold in the circulation of women with GDM. This is the first report of STB‐EVs carrying a biologically active molecule that has the potential to regulate maternal insulin secretion.</jats:p> Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus Journal of Extracellular Vesicles |
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| title |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_unstemmed |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_full |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_fullStr |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_full_unstemmed |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_short |
Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_sort |
placental extracellular vesicles express active dipeptidyl peptidase iv; levels are increased in gestational diabetes mellitus |
| topic |
Cell Biology Histology |
| url |
http://dx.doi.org/10.1080/20013078.2019.1617000 |
| publishDate |
2019 |
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|
| description |
<jats:title>ABSTRACT</jats:title><jats:p>Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy and is characterized by insulin resistance and decreased circulating glucagon‐like peptide‐1 (GLP‐1). GDM resolves rapidly after delivery implicating the placenta in the disease. This study examines the biological functions that cause this pathology. The placenta releases syncytiotrophoblast‐derived extracellular vesicles (STB‐EVs) into the maternal circulation, which is enhanced in GDM. Dipeptidyl peptidase IV (DPPIV) is known to play a role in type 2 diabetes by breaking down GLP‐1, which in turn regulates glucose‐dependent insulin secretion. STB‐EVs from control and GDM women were analysed. We show that normal human placenta releases DPPIV‐positive STB‐EVs and that they are higher in uterine than paired peripheral blood, confirming placental origin. DPPIV‐bound STB‐EVs from normal perfused placentae are dose dependently inhibited with vildagliptin. DPPIV‐bound STB‐EVs from perfused placentae are able to breakdown GLP‐1 <jats:italic>in vitro</jats:italic>. STB‐EVs from GDM perfused placentae show greater DPPIV activity. Importantly, DPPIV‐bound STB‐EVs increase eightfold in the circulation of women with GDM. This is the first report of STB‐EVs carrying a biologically active molecule that has the potential to regulate maternal insulin secretion.</jats:p> |
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| author | Kandzija, Neva, Zhang, Wei, Motta‐Mejia, Carolina, Mhlomi, Vuyane, McGowan‐Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu |
| author_facet | Kandzija, Neva, Zhang, Wei, Motta‐Mejia, Carolina, Mhlomi, Vuyane, McGowan‐Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu, Kandzija, Neva, Zhang, Wei, Motta‐Mejia, Carolina, Mhlomi, Vuyane, McGowan‐Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu |
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| description | <jats:title>ABSTRACT</jats:title><jats:p>Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy and is characterized by insulin resistance and decreased circulating glucagon‐like peptide‐1 (GLP‐1). GDM resolves rapidly after delivery implicating the placenta in the disease. This study examines the biological functions that cause this pathology. The placenta releases syncytiotrophoblast‐derived extracellular vesicles (STB‐EVs) into the maternal circulation, which is enhanced in GDM. Dipeptidyl peptidase IV (DPPIV) is known to play a role in type 2 diabetes by breaking down GLP‐1, which in turn regulates glucose‐dependent insulin secretion. STB‐EVs from control and GDM women were analysed. We show that normal human placenta releases DPPIV‐positive STB‐EVs and that they are higher in uterine than paired peripheral blood, confirming placental origin. DPPIV‐bound STB‐EVs from normal perfused placentae are dose dependently inhibited with vildagliptin. DPPIV‐bound STB‐EVs from perfused placentae are able to breakdown GLP‐1 <jats:italic>in vitro</jats:italic>. STB‐EVs from GDM perfused placentae show greater DPPIV activity. Importantly, DPPIV‐bound STB‐EVs increase eightfold in the circulation of women with GDM. This is the first report of STB‐EVs carrying a biologically active molecule that has the potential to regulate maternal insulin secretion.</jats:p> |
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| spelling | Kandzija, Neva Zhang, Wei Motta‐Mejia, Carolina Mhlomi, Vuyane McGowan‐Downey, Jennifer James, Tim Cerdeira, Ana Sofia Tannetta, Dionne Sargent, Ian Redman, Christopher W. Bastie, Claire C. Vatish, Manu 2001-3078 2001-3078 Wiley Cell Biology Histology http://dx.doi.org/10.1080/20013078.2019.1617000 <jats:title>ABSTRACT</jats:title><jats:p>Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy and is characterized by insulin resistance and decreased circulating glucagon‐like peptide‐1 (GLP‐1). GDM resolves rapidly after delivery implicating the placenta in the disease. This study examines the biological functions that cause this pathology. The placenta releases syncytiotrophoblast‐derived extracellular vesicles (STB‐EVs) into the maternal circulation, which is enhanced in GDM. Dipeptidyl peptidase IV (DPPIV) is known to play a role in type 2 diabetes by breaking down GLP‐1, which in turn regulates glucose‐dependent insulin secretion. STB‐EVs from control and GDM women were analysed. We show that normal human placenta releases DPPIV‐positive STB‐EVs and that they are higher in uterine than paired peripheral blood, confirming placental origin. DPPIV‐bound STB‐EVs from normal perfused placentae are dose dependently inhibited with vildagliptin. DPPIV‐bound STB‐EVs from perfused placentae are able to breakdown GLP‐1 <jats:italic>in vitro</jats:italic>. STB‐EVs from GDM perfused placentae show greater DPPIV activity. Importantly, DPPIV‐bound STB‐EVs increase eightfold in the circulation of women with GDM. This is the first report of STB‐EVs carrying a biologically active molecule that has the potential to regulate maternal insulin secretion.</jats:p> Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus Journal of Extracellular Vesicles |
| spellingShingle | Kandzija, Neva, Zhang, Wei, Motta‐Mejia, Carolina, Mhlomi, Vuyane, McGowan‐Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu, Journal of Extracellular Vesicles, Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus, Cell Biology, Histology |
| title | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_full | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_fullStr | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_full_unstemmed | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_short | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| title_sort | placental extracellular vesicles express active dipeptidyl peptidase iv; levels are increased in gestational diabetes mellitus |
| title_unstemmed | Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus |
| topic | Cell Biology, Histology |
| url | http://dx.doi.org/10.1080/20013078.2019.1617000 |