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Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study: A phase III multicentre study
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| Zeitschriftentitel: | Acta Radiologica |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Acta Radiologica, 38, 1997, 5, S. 643-649 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. |
|---|---|
| author |
Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. |
| spellingShingle |
Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. Acta Radiologica Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study Radiology, Nuclear Medicine and imaging General Medicine Radiological and Ultrasound Technology |
| author_sort |
wang, c. |
| spelling |
Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. 0284-1851 1600-0455 SAGE Publications Radiology, Nuclear Medicine and imaging General Medicine Radiological and Ultrasound Technology http://dx.doi.org/10.1080/02841859709172395 <jats:p> Purpose: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. </jats:p><jats:p> Material and Methods: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 μmol/kg b.w. was administered by slow i.v. infusion, and 20–60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. </jats:p><jats:p> Results: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. </jats:p><jats:p> Conclusion: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions. </jats:p> A phase III multicentre study Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study Acta Radiologica |
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A phase III multicentre study |
| title |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_unstemmed |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_full |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_fullStr |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_full_unstemmed |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_short |
Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_sort |
diagnostic efficacy of mndpdp in mr imaging of the liver : a phase iii multicentre study |
| topic |
Radiology, Nuclear Medicine and imaging General Medicine Radiological and Ultrasound Technology |
| url |
http://dx.doi.org/10.1080/02841859709172395 |
| publishDate |
1997 |
| physical |
643-649 |
| description |
<jats:p> Purpose: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. </jats:p><jats:p> Material and Methods: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 μmol/kg b.w. was administered by slow i.v. infusion, and 20–60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. </jats:p><jats:p> Results: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. </jats:p><jats:p> Conclusion: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions. </jats:p> |
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| author | Wang, C., Ahlström, H., Ekholm, S., Fagertun, H., Hellström, M., Hemmingsson, A., Holtås, S., Isberg, B., Jonnson, E., Lönnemark-Magnusson, M., McGill, S., Wallengren, N.-O., Westman, L. |
| author_facet | Wang, C., Ahlström, H., Ekholm, S., Fagertun, H., Hellström, M., Hemmingsson, A., Holtås, S., Isberg, B., Jonnson, E., Lönnemark-Magnusson, M., McGill, S., Wallengren, N.-O., Westman, L., Wang, C., Ahlström, H., Ekholm, S., Fagertun, H., Hellström, M., Hemmingsson, A., Holtås, S., Isberg, B., Jonnson, E., Lönnemark-Magnusson, M., McGill, S., Wallengren, N.-O., Westman, L. |
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| description | <jats:p> Purpose: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. </jats:p><jats:p> Material and Methods: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 μmol/kg b.w. was administered by slow i.v. infusion, and 20–60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. </jats:p><jats:p> Results: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. </jats:p><jats:p> Conclusion: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions. </jats:p> |
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| imprint | SAGE Publications, 1997 |
| imprint_str_mv | SAGE Publications, 1997 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4 |
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| spelling | Wang, C. Ahlström, H. Ekholm, S. Fagertun, H. Hellström, M. Hemmingsson, A. Holtås, S. Isberg, B. Jonnson, E. Lönnemark-Magnusson, M. McGill, S. Wallengren, N.-O. Westman, L. 0284-1851 1600-0455 SAGE Publications Radiology, Nuclear Medicine and imaging General Medicine Radiological and Ultrasound Technology http://dx.doi.org/10.1080/02841859709172395 <jats:p> Purpose: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. </jats:p><jats:p> Material and Methods: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 μmol/kg b.w. was administered by slow i.v. infusion, and 20–60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. </jats:p><jats:p> Results: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. </jats:p><jats:p> Conclusion: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions. </jats:p> A phase III multicentre study Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study Acta Radiologica |
| spellingShingle | Wang, C., Ahlström, H., Ekholm, S., Fagertun, H., Hellström, M., Hemmingsson, A., Holtås, S., Isberg, B., Jonnson, E., Lönnemark-Magnusson, M., McGill, S., Wallengren, N.-O., Westman, L., Acta Radiologica, Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study, Radiology, Nuclear Medicine and imaging, General Medicine, Radiological and Ultrasound Technology |
| title | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_full | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_fullStr | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_full_unstemmed | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_short | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| title_sort | diagnostic efficacy of mndpdp in mr imaging of the liver : a phase iii multicentre study |
| title_sub | A phase III multicentre study |
| title_unstemmed | Diagnostic efficacy of MnDPDP in MR imaging of the liver : A phase III multicentre study |
| topic | Radiology, Nuclear Medicine and imaging, General Medicine, Radiological and Ultrasound Technology |
| url | http://dx.doi.org/10.1080/02841859709172395 |