Eintrag weiter verarbeiten
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia
Gespeichert in:
| Zeitschriftentitel: | Nutrition Research Reviews |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Nutrition Research Reviews, 17, 2004, 2, S. 177-192 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. |
|---|---|
| author |
Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. |
| spellingShingle |
Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. Nutrition Research Reviews n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
baracos, vickie e. |
| spelling |
Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. 0954-4224 1475-2700 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1079/nrr200488 <jats:title>Abstract</jats:title><jats:p>Evidence from epidemiological studies suggests that diets rich in<jats:italic>n</jats:italic>-3 PUFA may be associated with reduced cancer risk. These observations have formed the rationale for exploring the mechanisms by which<jats:italic>n</jats:italic>-3 PUFA may be chemoprotective and have resulted in significant advances in our mechanistic understanding of<jats:italic>n</jats:italic>-3 PUFA action on tumour growth. Various interrelated and integrated mechanisms may be at work by which<jats:italic>n</jats:italic>-3 PUFA influence cancer at all stages of initiation, promotion, progression, and neoplastic transformation. More recently, experimental studies have reported enhanced tumour cell death with chemotherapy when fish oil is provided while toxic side effects to the host are reduced. Furthermore, cancer-associated wasting has been shown to be attenuated by fish oil supplementation. Clinical evidence suggests that the<jats:italic>n</jats:italic>-3 PUFA status of newly diagnosed cancer patients and individuals undergoing chemotherapy is low. Therefore, both the disease itself and therapeutic treatments may be contributing factors in the decline of<jats:italic>n</jats:italic>-3 PUFA status. Dietary supplementation to maintain and replenish<jats:italic>n</jats:italic>-3 PUFA status at key points in the cancer disease trajectory may provide additional health benefits and an enhanced quality of life. The present review will focus on and critically examine current research efforts related to the putative anti-cancer effects of<jats:italic>n</jats:italic>-3 PUFA and their suggested ability to palliate cancer-associated and treatment-associated symptoms.</jats:p> <i>n</i>-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia Nutrition Research Reviews |
| doi_str_mv |
10.1079/nrr200488 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3OS9ucnIyMDA0ODg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3OS9ucnIyMDA0ODg |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Cambridge University Press (CUP), 2004 |
| imprint_str_mv |
Cambridge University Press (CUP), 2004 |
| issn |
0954-4224 1475-2700 |
| issn_str_mv |
0954-4224 1475-2700 |
| language |
English |
| mega_collection |
Cambridge University Press (CUP) (CrossRef) |
| match_str |
baracos2004n3polyunsaturatedfattyacidsthroughoutthecancertrajectoryinfluenceondiseaseincidenceprogressionresponsetotherapyandcancerassociatedcachexia |
| publishDateSort |
2004 |
| publisher |
Cambridge University Press (CUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
Nutrition Research Reviews |
| source_id |
49 |
| title |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_unstemmed |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_full |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_fullStr |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_full_unstemmed |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_short |
n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_sort |
<i>n</i>-3 polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| topic |
Nutrition and Dietetics Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1079/nrr200488 |
| publishDate |
2004 |
| physical |
177-192 |
| description |
<jats:title>Abstract</jats:title><jats:p>Evidence from epidemiological studies suggests that diets rich in<jats:italic>n</jats:italic>-3 PUFA may be associated with reduced cancer risk. These observations have formed the rationale for exploring the mechanisms by which<jats:italic>n</jats:italic>-3 PUFA may be chemoprotective and have resulted in significant advances in our mechanistic understanding of<jats:italic>n</jats:italic>-3 PUFA action on tumour growth. Various interrelated and integrated mechanisms may be at work by which<jats:italic>n</jats:italic>-3 PUFA influence cancer at all stages of initiation, promotion, progression, and neoplastic transformation. More recently, experimental studies have reported enhanced tumour cell death with chemotherapy when fish oil is provided while toxic side effects to the host are reduced. Furthermore, cancer-associated wasting has been shown to be attenuated by fish oil supplementation. Clinical evidence suggests that the<jats:italic>n</jats:italic>-3 PUFA status of newly diagnosed cancer patients and individuals undergoing chemotherapy is low. Therefore, both the disease itself and therapeutic treatments may be contributing factors in the decline of<jats:italic>n</jats:italic>-3 PUFA status. Dietary supplementation to maintain and replenish<jats:italic>n</jats:italic>-3 PUFA status at key points in the cancer disease trajectory may provide additional health benefits and an enhanced quality of life. The present review will focus on and critically examine current research efforts related to the putative anti-cancer effects of<jats:italic>n</jats:italic>-3 PUFA and their suggested ability to palliate cancer-associated and treatment-associated symptoms.</jats:p> |
| container_issue |
2 |
| container_start_page |
177 |
| container_title |
Nutrition Research Reviews |
| container_volume |
17 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339353652953089 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:46:47.156Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=n-3+Polyunsaturated+fatty+acids+throughout+the+cancer+trajectory%3A+influence+on+disease+incidence%2C+progression%2C+response+to+therapy+and+cancer-associated+cachexia&rft.date=2004-12-01&genre=article&issn=1475-2700&volume=17&issue=2&spage=177&epage=192&pages=177-192&jtitle=Nutrition+Research+Reviews&atitle=%3Ci%3En%3C%2Fi%3E-3+Polyunsaturated+fatty+acids+throughout+the+cancer+trajectory%3A+influence+on+disease+incidence%2C+progression%2C+response+to+therapy+and+cancer-associated+cachexia&aulast=Ma&aufirst=David+W.+L.&rft_id=info%3Adoi%2F10.1079%2Fnrr200488&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339353652953089 |
| author | Baracos, Vickie E., Mazurak, Vera C., Ma, David W. L. |
| author_facet | Baracos, Vickie E., Mazurak, Vera C., Ma, David W. L., Baracos, Vickie E., Mazurak, Vera C., Ma, David W. L. |
| author_sort | baracos, vickie e. |
| container_issue | 2 |
| container_start_page | 177 |
| container_title | Nutrition Research Reviews |
| container_volume | 17 |
| description | <jats:title>Abstract</jats:title><jats:p>Evidence from epidemiological studies suggests that diets rich in<jats:italic>n</jats:italic>-3 PUFA may be associated with reduced cancer risk. These observations have formed the rationale for exploring the mechanisms by which<jats:italic>n</jats:italic>-3 PUFA may be chemoprotective and have resulted in significant advances in our mechanistic understanding of<jats:italic>n</jats:italic>-3 PUFA action on tumour growth. Various interrelated and integrated mechanisms may be at work by which<jats:italic>n</jats:italic>-3 PUFA influence cancer at all stages of initiation, promotion, progression, and neoplastic transformation. More recently, experimental studies have reported enhanced tumour cell death with chemotherapy when fish oil is provided while toxic side effects to the host are reduced. Furthermore, cancer-associated wasting has been shown to be attenuated by fish oil supplementation. Clinical evidence suggests that the<jats:italic>n</jats:italic>-3 PUFA status of newly diagnosed cancer patients and individuals undergoing chemotherapy is low. Therefore, both the disease itself and therapeutic treatments may be contributing factors in the decline of<jats:italic>n</jats:italic>-3 PUFA status. Dietary supplementation to maintain and replenish<jats:italic>n</jats:italic>-3 PUFA status at key points in the cancer disease trajectory may provide additional health benefits and an enhanced quality of life. The present review will focus on and critically examine current research efforts related to the putative anti-cancer effects of<jats:italic>n</jats:italic>-3 PUFA and their suggested ability to palliate cancer-associated and treatment-associated symptoms.</jats:p> |
| doi_str_mv | 10.1079/nrr200488 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3OS9ucnIyMDA0ODg |
| imprint | Cambridge University Press (CUP), 2004 |
| imprint_str_mv | Cambridge University Press (CUP), 2004 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 0954-4224, 1475-2700 |
| issn_str_mv | 0954-4224, 1475-2700 |
| language | English |
| last_indexed | 2024-03-01T15:46:47.156Z |
| match_str | baracos2004n3polyunsaturatedfattyacidsthroughoutthecancertrajectoryinfluenceondiseaseincidenceprogressionresponsetotherapyandcancerassociatedcachexia |
| mega_collection | Cambridge University Press (CUP) (CrossRef) |
| physical | 177-192 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | Cambridge University Press (CUP) |
| record_format | ai |
| recordtype | ai |
| series | Nutrition Research Reviews |
| source_id | 49 |
| spelling | Baracos, Vickie E. Mazurak, Vera C. Ma, David W. L. 0954-4224 1475-2700 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1079/nrr200488 <jats:title>Abstract</jats:title><jats:p>Evidence from epidemiological studies suggests that diets rich in<jats:italic>n</jats:italic>-3 PUFA may be associated with reduced cancer risk. These observations have formed the rationale for exploring the mechanisms by which<jats:italic>n</jats:italic>-3 PUFA may be chemoprotective and have resulted in significant advances in our mechanistic understanding of<jats:italic>n</jats:italic>-3 PUFA action on tumour growth. Various interrelated and integrated mechanisms may be at work by which<jats:italic>n</jats:italic>-3 PUFA influence cancer at all stages of initiation, promotion, progression, and neoplastic transformation. More recently, experimental studies have reported enhanced tumour cell death with chemotherapy when fish oil is provided while toxic side effects to the host are reduced. Furthermore, cancer-associated wasting has been shown to be attenuated by fish oil supplementation. Clinical evidence suggests that the<jats:italic>n</jats:italic>-3 PUFA status of newly diagnosed cancer patients and individuals undergoing chemotherapy is low. Therefore, both the disease itself and therapeutic treatments may be contributing factors in the decline of<jats:italic>n</jats:italic>-3 PUFA status. Dietary supplementation to maintain and replenish<jats:italic>n</jats:italic>-3 PUFA status at key points in the cancer disease trajectory may provide additional health benefits and an enhanced quality of life. The present review will focus on and critically examine current research efforts related to the putative anti-cancer effects of<jats:italic>n</jats:italic>-3 PUFA and their suggested ability to palliate cancer-associated and treatment-associated symptoms.</jats:p> <i>n</i>-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia Nutrition Research Reviews |
| spellingShingle | Baracos, Vickie E., Mazurak, Vera C., Ma, David W. L., Nutrition Research Reviews, n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_full | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_fullStr | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_full_unstemmed | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_short | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_sort | <i>n</i>-3 polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| title_unstemmed | n-3 Polyunsaturated fatty acids throughout the cancer trajectory: influence on disease incidence, progression, response to therapy and cancer-associated cachexia |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1079/nrr200488 |