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Inulin and oligofructose: effects on lipid metabolism from human studies
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| Zeitschriftentitel: | British Journal of Nutrition |
|---|---|
| Personen und Körperschaften: | , |
| In: | British Journal of Nutrition, 87, 2002, S2, S. S261-S264 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Williams, C. M. Jackson, K. G. Williams, C. M. Jackson, K. G. |
|---|---|
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Williams, C. M. Jackson, K. G. |
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Williams, C. M. Jackson, K. G. British Journal of Nutrition Inulin and oligofructose: effects on lipid metabolism from human studies Nutrition and Dietetics Medicine (miscellaneous) |
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williams, c. m. |
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Williams, C. M. Jackson, K. G. 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1079/bjn/2002546 <jats:p>Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.</jats:p> Inulin and oligofructose: effects on lipid metabolism from human studies British Journal of Nutrition |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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Inulin and oligofructose: effects on lipid metabolism from human studies |
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inulin and oligofructose: effects on lipid metabolism from human studies |
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Nutrition and Dietetics Medicine (miscellaneous) |
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http://dx.doi.org/10.1079/bjn/2002546 |
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2002 |
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S261-S264 |
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<jats:p>Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.</jats:p> |
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| description | <jats:p>Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.</jats:p> |
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| spelling | Williams, C. M. Jackson, K. G. 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1079/bjn/2002546 <jats:p>Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar effects in man have produced conflicting findings. This may be because of the much lower doses which can be used due to the adverse gastrointestinal symptoms exhibited by most subjects consuming in excess of 15 g/d. There are nine studies reported in the literature which have investigated the response of blood lipids (usually total and LDL-cholesterol and triacylglycerol) to inulin or oligofructose supplementation in human volunteers. Three have observed no effects of inulin or oligofructose on blood levels of cholesterol or triacylglycerol, three have shown significant reductions in triacylglycerol, whilst four have shown modest reductions in total and LDL-cholesterol. Studies have been conducted in both normo- and moderately hyperlipidaemic subjects. Differences in study outcomes do not appear to be due to differences in the type or dose of oligosaccharides used nor the duration of the studies. Because animal studies have identified inhibition of hepatic fatty acid synthesis as the major site of action for the triacylglycerol lowering effects of inulin and oligofructose, and because this pathway is relatively inactive in man unless a high carbohydrate diet is fed, variability in response may be a reflection of differences in background diet or the experimental foods used.</jats:p> Inulin and oligofructose: effects on lipid metabolism from human studies British Journal of Nutrition |
| spellingShingle | Williams, C. M., Jackson, K. G., British Journal of Nutrition, Inulin and oligofructose: effects on lipid metabolism from human studies, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Inulin and oligofructose: effects on lipid metabolism from human studies |
| title_full | Inulin and oligofructose: effects on lipid metabolism from human studies |
| title_fullStr | Inulin and oligofructose: effects on lipid metabolism from human studies |
| title_full_unstemmed | Inulin and oligofructose: effects on lipid metabolism from human studies |
| title_short | Inulin and oligofructose: effects on lipid metabolism from human studies |
| title_sort | inulin and oligofructose: effects on lipid metabolism from human studies |
| title_unstemmed | Inulin and oligofructose: effects on lipid metabolism from human studies |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1079/bjn/2002546 |