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Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 68, 1971, 7, S. 1623-1626 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Hart, Michael M. Adamson, Richard H. Hart, Michael M. Adamson, Richard H. |
|---|---|
| author |
Hart, Michael M. Adamson, Richard H. |
| spellingShingle |
Hart, Michael M. Adamson, Richard H. Proceedings of the National Academy of Sciences Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium Multidisciplinary |
| author_sort |
hart, michael m. |
| spelling |
Hart, Michael M. Adamson, Richard H. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.68.7.1623 <jats:p> The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose) <jats:sub>50</jats:sub> as a measure, the decreasing order of toxicity was TlCl <jats:sub>3</jats:sub> ≥ In(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Al(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> . All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga <jats:sup>+3</jats:sup> and, to a lesser extent, In <jats:sup>+3</jats:sup> inhibited tumor growth. Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man. </jats:p> Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium Proceedings of the National Academy of Sciences |
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10.1073/pnas.68.7.1623 |
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Proceedings of the National Academy of Sciences, 1971 |
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Proceedings of the National Academy of Sciences, 1971 |
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1971 |
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49 |
| title |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_unstemmed |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_full |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_fullStr |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_full_unstemmed |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_short |
Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_sort |
antitumor activity and toxicity of salts of inorganic group iiia metals: aluminum, gallium, indium, and thallium |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.68.7.1623 |
| publishDate |
1971 |
| physical |
1623-1626 |
| description |
<jats:p>
The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)
<jats:sub>50</jats:sub>
as a measure, the decreasing order of toxicity was TlCl
<jats:sub>3</jats:sub>
≥ In(NO
<jats:sub>3</jats:sub>
)
<jats:sub>3</jats:sub>
> Ga(NO
<jats:sub>3</jats:sub>
)
<jats:sub>3</jats:sub>
> Al(NO
<jats:sub>3</jats:sub>
)
<jats:sub>3</jats:sub>
. All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga
<jats:sup>+3</jats:sup>
and, to a lesser extent, In
<jats:sup>+3</jats:sup>
inhibited tumor growth. Ga(NO
<jats:sub>3</jats:sub>
)
<jats:sub>3</jats:sub>
was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.
</jats:p> |
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| author | Hart, Michael M., Adamson, Richard H. |
| author_facet | Hart, Michael M., Adamson, Richard H., Hart, Michael M., Adamson, Richard H. |
| author_sort | hart, michael m. |
| container_issue | 7 |
| container_start_page | 1623 |
| container_title | Proceedings of the National Academy of Sciences |
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| description | <jats:p> The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose) <jats:sub>50</jats:sub> as a measure, the decreasing order of toxicity was TlCl <jats:sub>3</jats:sub> ≥ In(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Al(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> . All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga <jats:sup>+3</jats:sup> and, to a lesser extent, In <jats:sup>+3</jats:sup> inhibited tumor growth. Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man. </jats:p> |
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| imprint_str_mv | Proceedings of the National Academy of Sciences, 1971 |
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| physical | 1623-1626 |
| publishDate | 1971 |
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| series | Proceedings of the National Academy of Sciences |
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| spelling | Hart, Michael M. Adamson, Richard H. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.68.7.1623 <jats:p> The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose) <jats:sub>50</jats:sub> as a measure, the decreasing order of toxicity was TlCl <jats:sub>3</jats:sub> ≥ In(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> > Al(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> . All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga <jats:sup>+3</jats:sup> and, to a lesser extent, In <jats:sup>+3</jats:sup> inhibited tumor growth. Ga(NO <jats:sub>3</jats:sub> ) <jats:sub>3</jats:sub> was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man. </jats:p> Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium Proceedings of the National Academy of Sciences |
| spellingShingle | Hart, Michael M., Adamson, Richard H., Proceedings of the National Academy of Sciences, Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium, Multidisciplinary |
| title | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_full | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_fullStr | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_full_unstemmed | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_short | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| title_sort | antitumor activity and toxicity of salts of inorganic group iiia metals: aluminum, gallium, indium, and thallium |
| title_unstemmed | Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.68.7.1623 |