Eintrag weiter verarbeiten
Siah-1 binds and regulates the function of Numb
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 98, 2001, 26, S. 15067-15072 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam |
|---|---|
| author |
Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam |
| spellingShingle |
Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam Proceedings of the National Academy of Sciences Siah-1 binds and regulates the function of Numb Multidisciplinary |
| author_sort |
susini, laurent |
| spelling |
Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.261571998 <jats:p> The <jats:italic>Drosophila</jats:italic> <jats:italic>Seven in absentia</jats:italic> ( <jats:italic>Sina</jats:italic> ) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G <jats:sub>1</jats:sub> arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling. </jats:p> Siah-1 binds and regulates the function of Numb Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.261571998 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjI2MTU3MTk5OA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjI2MTU3MTk5OA |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
| imprint |
Proceedings of the National Academy of Sciences, 2001 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2001 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
susini2001siah1bindsandregulatesthefunctionofnumb |
| publishDateSort |
2001 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Siah-1 binds and regulates the function of Numb |
| title_unstemmed |
Siah-1 binds and regulates the function of Numb |
| title_full |
Siah-1 binds and regulates the function of Numb |
| title_fullStr |
Siah-1 binds and regulates the function of Numb |
| title_full_unstemmed |
Siah-1 binds and regulates the function of Numb |
| title_short |
Siah-1 binds and regulates the function of Numb |
| title_sort |
siah-1 binds and regulates the function of numb |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.261571998 |
| publishDate |
2001 |
| physical |
15067-15072 |
| description |
<jats:p>
The
<jats:italic>Drosophila</jats:italic>
<jats:italic>Seven in absentia</jats:italic>
(
<jats:italic>Sina</jats:italic>
) gene product originally was described as a
protein that controls cell fate decisions during eye development. Its
mammalian homolog, Siah-1, recently was found to be involved in
p53-dependent and -independent pathways of apoptosis and
G
<jats:sub>1</jats:sub>
arrest. We report that Siah-1 interacts directly with
and promotes the degradation of the cell fate regulator Numb.
Siah-1-mediated Numb degradation leads to redistribution of
endogenous cell-surface Notch to the cytoplasm and nucleus
and to augmented Notch-regulated transcriptional activity. These data
imply that through its ability to target Numb for degradation, Siah-1
can act as a key regulator of Numb-related activities, including Notch
signaling.
</jats:p> |
| container_issue |
26 |
| container_start_page |
15067 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
98 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344592943677441 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:10:04.397Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Siah-1+binds+and+regulates+the+function+of+Numb&rft.date=2001-12-18&genre=article&issn=1091-6490&volume=98&issue=26&spage=15067&epage=15072&pages=15067-15072&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Siah-1+binds+and+regulates+the+function+of+Numb&aulast=Telerman&aufirst=Adam&rft_id=info%3Adoi%2F10.1073%2Fpnas.261571998&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344592943677441 |
| author | Susini, Laurent, Passer, Brent J., Amzallag-Elbaz, Nathalie, Juven-Gershon, Tamar, Prieur, Sylvie, Privat, Nicolas, Tuynder, Marcel, Gendron, Marie-Claude, Israël, Alain, Amson, Robert, Oren, Moshe, Telerman, Adam |
| author_facet | Susini, Laurent, Passer, Brent J., Amzallag-Elbaz, Nathalie, Juven-Gershon, Tamar, Prieur, Sylvie, Privat, Nicolas, Tuynder, Marcel, Gendron, Marie-Claude, Israël, Alain, Amson, Robert, Oren, Moshe, Telerman, Adam, Susini, Laurent, Passer, Brent J., Amzallag-Elbaz, Nathalie, Juven-Gershon, Tamar, Prieur, Sylvie, Privat, Nicolas, Tuynder, Marcel, Gendron, Marie-Claude, Israël, Alain, Amson, Robert, Oren, Moshe, Telerman, Adam |
| author_sort | susini, laurent |
| container_issue | 26 |
| container_start_page | 15067 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 98 |
| description | <jats:p> The <jats:italic>Drosophila</jats:italic> <jats:italic>Seven in absentia</jats:italic> ( <jats:italic>Sina</jats:italic> ) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G <jats:sub>1</jats:sub> arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling. </jats:p> |
| doi_str_mv | 10.1073/pnas.261571998 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjI2MTU3MTk5OA |
| imprint | Proceedings of the National Academy of Sciences, 2001 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2001 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:10:04.397Z |
| match_str | susini2001siah1bindsandregulatesthefunctionofnumb |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 15067-15072 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Susini, Laurent Passer, Brent J. Amzallag-Elbaz, Nathalie Juven-Gershon, Tamar Prieur, Sylvie Privat, Nicolas Tuynder, Marcel Gendron, Marie-Claude Israël, Alain Amson, Robert Oren, Moshe Telerman, Adam 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.261571998 <jats:p> The <jats:italic>Drosophila</jats:italic> <jats:italic>Seven in absentia</jats:italic> ( <jats:italic>Sina</jats:italic> ) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G <jats:sub>1</jats:sub> arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling. </jats:p> Siah-1 binds and regulates the function of Numb Proceedings of the National Academy of Sciences |
| spellingShingle | Susini, Laurent, Passer, Brent J., Amzallag-Elbaz, Nathalie, Juven-Gershon, Tamar, Prieur, Sylvie, Privat, Nicolas, Tuynder, Marcel, Gendron, Marie-Claude, Israël, Alain, Amson, Robert, Oren, Moshe, Telerman, Adam, Proceedings of the National Academy of Sciences, Siah-1 binds and regulates the function of Numb, Multidisciplinary |
| title | Siah-1 binds and regulates the function of Numb |
| title_full | Siah-1 binds and regulates the function of Numb |
| title_fullStr | Siah-1 binds and regulates the function of Numb |
| title_full_unstemmed | Siah-1 binds and regulates the function of Numb |
| title_short | Siah-1 binds and regulates the function of Numb |
| title_sort | siah-1 binds and regulates the function of numb |
| title_unstemmed | Siah-1 binds and regulates the function of Numb |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.261571998 |