Eintrag weiter verarbeiten
Competition is a driving force in topographic mapping
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 108, 2011, 47, S. 19060-19065 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. |
|---|---|
| author |
Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. |
| spellingShingle |
Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. Proceedings of the National Academy of Sciences Competition is a driving force in topographic mapping Multidisciplinary |
| author_sort |
triplett, jason w. |
| spelling |
Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1102834108 <jats:p>Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and patterned retinal activity are required for topographic map formation. Additionally, interaxon competition has been suggested to play a role in topographic map formation; however, this view has been recently challenged. Here we present experimental and computational evidence demonstrating that interaxon competition for target space is necessary to establish topography. To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC. We find that in these mice, retinal axons project to the anteromedialj portion of the SC where repulsion from ephrin-A ligands is minimized and where their attraction to the midline is maximized. This observation is consistent with the chemoaffinity model that relies on axon–axon competition as a mapping mechanism. We conclude that chemical labels plus neural activity cannot alone specify the retinocollicular projection; instead axon–axon competition is necessary to create a map. Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition.</jats:p> Competition is a driving force in topographic mapping Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.1102834108 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMDI4MzQxMDg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMDI4MzQxMDg |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Proceedings of the National Academy of Sciences, 2011 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2011 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
triplett2011competitionisadrivingforceintopographicmapping |
| publishDateSort |
2011 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Competition is a driving force in topographic mapping |
| title_unstemmed |
Competition is a driving force in topographic mapping |
| title_full |
Competition is a driving force in topographic mapping |
| title_fullStr |
Competition is a driving force in topographic mapping |
| title_full_unstemmed |
Competition is a driving force in topographic mapping |
| title_short |
Competition is a driving force in topographic mapping |
| title_sort |
competition is a driving force in topographic mapping |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1102834108 |
| publishDate |
2011 |
| physical |
19060-19065 |
| description |
<jats:p>Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and patterned retinal activity are required for topographic map formation. Additionally, interaxon competition has been suggested to play a role in topographic map formation; however, this view has been recently challenged. Here we present experimental and computational evidence demonstrating that interaxon competition for target space is necessary to establish topography. To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC. We find that in these mice, retinal axons project to the anteromedialj portion of the SC where repulsion from ephrin-A ligands is minimized and where their attraction to the midline is maximized. This observation is consistent with the chemoaffinity model that relies on axon–axon competition as a mapping mechanism. We conclude that chemical labels plus neural activity cannot alone specify the retinocollicular projection; instead axon–axon competition is necessary to create a map. Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition.</jats:p> |
| container_issue |
47 |
| container_start_page |
19060 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
108 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348309164130307 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:08:48.801Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Competition+is+a+driving+force+in+topographic+mapping&rft.date=2011-11-22&genre=article&issn=1091-6490&volume=108&issue=47&spage=19060&epage=19065&pages=19060-19065&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Competition+is+a+driving+force+in+topographic+mapping&aulast=Feldheim&aufirst=David+A.&rft_id=info%3Adoi%2F10.1073%2Fpnas.1102834108&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348309164130307 |
| author | Triplett, Jason W., Pfeiffenberger, Cory, Yamada, Jena, Stafford, Ben K., Sweeney, Neal T., Litke, Alan M., Sher, Alexander, Koulakov, Alexei A., Feldheim, David A. |
| author_facet | Triplett, Jason W., Pfeiffenberger, Cory, Yamada, Jena, Stafford, Ben K., Sweeney, Neal T., Litke, Alan M., Sher, Alexander, Koulakov, Alexei A., Feldheim, David A., Triplett, Jason W., Pfeiffenberger, Cory, Yamada, Jena, Stafford, Ben K., Sweeney, Neal T., Litke, Alan M., Sher, Alexander, Koulakov, Alexei A., Feldheim, David A. |
| author_sort | triplett, jason w. |
| container_issue | 47 |
| container_start_page | 19060 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 108 |
| description | <jats:p>Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and patterned retinal activity are required for topographic map formation. Additionally, interaxon competition has been suggested to play a role in topographic map formation; however, this view has been recently challenged. Here we present experimental and computational evidence demonstrating that interaxon competition for target space is necessary to establish topography. To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC. We find that in these mice, retinal axons project to the anteromedialj portion of the SC where repulsion from ephrin-A ligands is minimized and where their attraction to the midline is maximized. This observation is consistent with the chemoaffinity model that relies on axon–axon competition as a mapping mechanism. We conclude that chemical labels plus neural activity cannot alone specify the retinocollicular projection; instead axon–axon competition is necessary to create a map. Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition.</jats:p> |
| doi_str_mv | 10.1073/pnas.1102834108 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMDI4MzQxMDg |
| imprint | Proceedings of the National Academy of Sciences, 2011 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2011 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T18:08:48.801Z |
| match_str | triplett2011competitionisadrivingforceintopographicmapping |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 19060-19065 |
| publishDate | 2011 |
| publishDateSort | 2011 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Triplett, Jason W. Pfeiffenberger, Cory Yamada, Jena Stafford, Ben K. Sweeney, Neal T. Litke, Alan M. Sher, Alexander Koulakov, Alexei A. Feldheim, David A. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1102834108 <jats:p>Topographic maps are the primary means of relaying spatial information in the brain. Understanding the mechanisms by which they form has been a goal of experimental and theoretical neuroscientists for decades. The projection of the retina to the superior colliculus (SC)/tectum has been an important model used to show that graded molecular cues and patterned retinal activity are required for topographic map formation. Additionally, interaxon competition has been suggested to play a role in topographic map formation; however, this view has been recently challenged. Here we present experimental and computational evidence demonstrating that interaxon competition for target space is necessary to establish topography. To test this hypothesis experimentally, we determined the nature of the retinocollicular projection in Math5 (Atoh7) mutant mice, which have severely reduced numbers of retinal ganglion cell inputs into the SC. We find that in these mice, retinal axons project to the anteromedialj portion of the SC where repulsion from ephrin-A ligands is minimized and where their attraction to the midline is maximized. This observation is consistent with the chemoaffinity model that relies on axon–axon competition as a mapping mechanism. We conclude that chemical labels plus neural activity cannot alone specify the retinocollicular projection; instead axon–axon competition is necessary to create a map. Finally, we present a mathematical model for topographic mapping that incorporates molecular labels, neural activity, and axon competition.</jats:p> Competition is a driving force in topographic mapping Proceedings of the National Academy of Sciences |
| spellingShingle | Triplett, Jason W., Pfeiffenberger, Cory, Yamada, Jena, Stafford, Ben K., Sweeney, Neal T., Litke, Alan M., Sher, Alexander, Koulakov, Alexei A., Feldheim, David A., Proceedings of the National Academy of Sciences, Competition is a driving force in topographic mapping, Multidisciplinary |
| title | Competition is a driving force in topographic mapping |
| title_full | Competition is a driving force in topographic mapping |
| title_fullStr | Competition is a driving force in topographic mapping |
| title_full_unstemmed | Competition is a driving force in topographic mapping |
| title_short | Competition is a driving force in topographic mapping |
| title_sort | competition is a driving force in topographic mapping |
| title_unstemmed | Competition is a driving force in topographic mapping |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1102834108 |