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Full regeneration of the tribasal Polypterus fin
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Proceedings of the National Academy of Sciences, 109, 2012, 10, S. 3838-3843 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis |
|---|---|
| author |
Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis |
| spellingShingle |
Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis Proceedings of the National Academy of Sciences Full regeneration of the tribasal Polypterus fin Multidisciplinary |
| author_sort |
cuervo, rodrigo |
| spelling |
Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1006619109 <jats:p> Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that <jats:italic>Polypterus</jats:italic> , the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy. Pectoral <jats:italic>Polypterus</jats:italic> fins are complex, formed by a well-organized endoskeleton to which the exoskeleton rays are connected. Regeneration initiates with the formation of a blastema similar to that observed in regenerating amphibian limbs. Retinoic acid induces dose-dependent phenotypes ranging from inhibition of regeneration to apparent anterior–posterior duplications. As in all developing tetrapod limbs and regenerating amphibian blastema, Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral fins, regeneration can resume after release from the arrest caused by hedgehog inhibition. A comparative analysis of fin phenotypes obtained after retinoic acid treatment or altering the hedgehog signaling levels during regeneration allowed us to assign a limb tetrapod equivalent segment to <jats:italic>Polypterus</jats:italic> fin skeletal structures, thus providing clues to the origin of the autopod. We propose that appendage regeneration was a common property of vertebrates during the fin to limb transition. </jats:p> Full regeneration of the tribasal <i>Polypterus</i> fin Proceedings of the National Academy of Sciences |
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| title |
Full regeneration of the tribasal Polypterus fin |
| title_unstemmed |
Full regeneration of the tribasal Polypterus fin |
| title_full |
Full regeneration of the tribasal Polypterus fin |
| title_fullStr |
Full regeneration of the tribasal Polypterus fin |
| title_full_unstemmed |
Full regeneration of the tribasal Polypterus fin |
| title_short |
Full regeneration of the tribasal Polypterus fin |
| title_sort |
full regeneration of the tribasal
<i>polypterus</i>
fin |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1006619109 |
| publishDate |
2012 |
| physical |
3838-3843 |
| description |
<jats:p>
Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that
<jats:italic>Polypterus</jats:italic>
, the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy. Pectoral
<jats:italic>Polypterus</jats:italic>
fins are complex, formed by a well-organized endoskeleton to which the exoskeleton rays are connected. Regeneration initiates with the formation of a blastema similar to that observed in regenerating amphibian limbs. Retinoic acid induces dose-dependent phenotypes ranging from inhibition of regeneration to apparent anterior–posterior duplications. As in all developing tetrapod limbs and regenerating amphibian blastema, Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral fins, regeneration can resume after release from the arrest caused by hedgehog inhibition. A comparative analysis of fin phenotypes obtained after retinoic acid treatment or altering the hedgehog signaling levels during regeneration allowed us to assign a limb tetrapod equivalent segment to
<jats:italic>Polypterus</jats:italic>
fin skeletal structures, thus providing clues to the origin of the autopod. We propose that appendage regeneration was a common property of vertebrates during the fin to limb transition.
</jats:p> |
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| author | Cuervo, Rodrigo, Hernández-Martínez, Rocío, Chimal-Monroy, Jesús, Merchant-Larios, Horacio, Covarrubias, Luis |
| author_facet | Cuervo, Rodrigo, Hernández-Martínez, Rocío, Chimal-Monroy, Jesús, Merchant-Larios, Horacio, Covarrubias, Luis, Cuervo, Rodrigo, Hernández-Martínez, Rocío, Chimal-Monroy, Jesús, Merchant-Larios, Horacio, Covarrubias, Luis |
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| container_title | Proceedings of the National Academy of Sciences |
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| description | <jats:p> Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that <jats:italic>Polypterus</jats:italic> , the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy. Pectoral <jats:italic>Polypterus</jats:italic> fins are complex, formed by a well-organized endoskeleton to which the exoskeleton rays are connected. Regeneration initiates with the formation of a blastema similar to that observed in regenerating amphibian limbs. Retinoic acid induces dose-dependent phenotypes ranging from inhibition of regeneration to apparent anterior–posterior duplications. As in all developing tetrapod limbs and regenerating amphibian blastema, Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral fins, regeneration can resume after release from the arrest caused by hedgehog inhibition. A comparative analysis of fin phenotypes obtained after retinoic acid treatment or altering the hedgehog signaling levels during regeneration allowed us to assign a limb tetrapod equivalent segment to <jats:italic>Polypterus</jats:italic> fin skeletal structures, thus providing clues to the origin of the autopod. We propose that appendage regeneration was a common property of vertebrates during the fin to limb transition. </jats:p> |
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| imprint_str_mv | Proceedings of the National Academy of Sciences, 2012 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T16:27:03.921Z |
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| spelling | Cuervo, Rodrigo Hernández-Martínez, Rocío Chimal-Monroy, Jesús Merchant-Larios, Horacio Covarrubias, Luis 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1006619109 <jats:p> Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that <jats:italic>Polypterus</jats:italic> , the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy. Pectoral <jats:italic>Polypterus</jats:italic> fins are complex, formed by a well-organized endoskeleton to which the exoskeleton rays are connected. Regeneration initiates with the formation of a blastema similar to that observed in regenerating amphibian limbs. Retinoic acid induces dose-dependent phenotypes ranging from inhibition of regeneration to apparent anterior–posterior duplications. As in all developing tetrapod limbs and regenerating amphibian blastema, Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral fins, regeneration can resume after release from the arrest caused by hedgehog inhibition. A comparative analysis of fin phenotypes obtained after retinoic acid treatment or altering the hedgehog signaling levels during regeneration allowed us to assign a limb tetrapod equivalent segment to <jats:italic>Polypterus</jats:italic> fin skeletal structures, thus providing clues to the origin of the autopod. We propose that appendage regeneration was a common property of vertebrates during the fin to limb transition. </jats:p> Full regeneration of the tribasal <i>Polypterus</i> fin Proceedings of the National Academy of Sciences |
| spellingShingle | Cuervo, Rodrigo, Hernández-Martínez, Rocío, Chimal-Monroy, Jesús, Merchant-Larios, Horacio, Covarrubias, Luis, Proceedings of the National Academy of Sciences, Full regeneration of the tribasal Polypterus fin, Multidisciplinary |
| title | Full regeneration of the tribasal Polypterus fin |
| title_full | Full regeneration of the tribasal Polypterus fin |
| title_fullStr | Full regeneration of the tribasal Polypterus fin |
| title_full_unstemmed | Full regeneration of the tribasal Polypterus fin |
| title_short | Full regeneration of the tribasal Polypterus fin |
| title_sort | full regeneration of the tribasal <i>polypterus</i> fin |
| title_unstemmed | Full regeneration of the tribasal Polypterus fin |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1006619109 |