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Mapping the parameters of prion-induced neuropathology
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 97, 2000, 19, S. 10573-10577 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Stumpf, Michael P. H. Krakauer, David C. Stumpf, Michael P. H. Krakauer, David C. |
|---|---|
| author |
Stumpf, Michael P. H. Krakauer, David C. |
| spellingShingle |
Stumpf, Michael P. H. Krakauer, David C. Proceedings of the National Academy of Sciences Mapping the parameters of prion-induced neuropathology Multidisciplinary |
| author_sort |
stumpf, michael p. h. |
| spelling |
Stumpf, Michael P. H. Krakauer, David C. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.180317097 <jats:p>We present a theoretical framework that enables us to dissect out the parametric dependencies of the pathogenesis of prion diseases. We are able to determine the influence of both host-dependent factors (connectivity, cell density, protein synthesis rate, and cell death) and strain-dependent factors (cell tropism, virulence, and replication rate). We use a model based on a linked system of differential equations on a lattice to explore how the regional distribution of central nervous system pathology in Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia relates to each of these factors. The model then is used to make qualitative predictions about the pathology for two possible hypothetical triggers of neuronal loss in prion diseases. Pathological progression in overexpressing mouse models has been shown to depend on the site of initial infection. The model allows us to compare the pathologies resulting from different inoculation routes.</jats:p> Mapping the parameters of prion-induced neuropathology Proceedings of the National Academy of Sciences |
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| title |
Mapping the parameters of prion-induced neuropathology |
| title_unstemmed |
Mapping the parameters of prion-induced neuropathology |
| title_full |
Mapping the parameters of prion-induced neuropathology |
| title_fullStr |
Mapping the parameters of prion-induced neuropathology |
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Mapping the parameters of prion-induced neuropathology |
| title_short |
Mapping the parameters of prion-induced neuropathology |
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mapping the parameters of prion-induced neuropathology |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.180317097 |
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2000 |
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10573-10577 |
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<jats:p>We present a theoretical framework that enables us to dissect out
the parametric dependencies of the pathogenesis of prion diseases. We
are able to determine the influence of both host-dependent factors
(connectivity, cell density, protein synthesis rate, and cell death)
and strain-dependent factors (cell tropism, virulence, and replication
rate). We use a model based on a linked system of differential
equations on a lattice to explore how the regional distribution of
central nervous system pathology in Creutzfeldt-Jakob disease,
Gerstmann-Sträussler-Scheinker syndrome, and fatal familial
insomnia relates to each of these factors. The model then is used to
make qualitative predictions about the pathology for two possible
hypothetical triggers of neuronal loss in prion diseases. Pathological
progression in overexpressing mouse models has been shown to depend on
the site of initial infection. The model allows us to compare the
pathologies resulting from different inoculation routes.</jats:p> |
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| author | Stumpf, Michael P. H., Krakauer, David C. |
| author_facet | Stumpf, Michael P. H., Krakauer, David C., Stumpf, Michael P. H., Krakauer, David C. |
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| description | <jats:p>We present a theoretical framework that enables us to dissect out the parametric dependencies of the pathogenesis of prion diseases. We are able to determine the influence of both host-dependent factors (connectivity, cell density, protein synthesis rate, and cell death) and strain-dependent factors (cell tropism, virulence, and replication rate). We use a model based on a linked system of differential equations on a lattice to explore how the regional distribution of central nervous system pathology in Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia relates to each of these factors. The model then is used to make qualitative predictions about the pathology for two possible hypothetical triggers of neuronal loss in prion diseases. Pathological progression in overexpressing mouse models has been shown to depend on the site of initial infection. The model allows us to compare the pathologies resulting from different inoculation routes.</jats:p> |
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| spelling | Stumpf, Michael P. H. Krakauer, David C. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.180317097 <jats:p>We present a theoretical framework that enables us to dissect out the parametric dependencies of the pathogenesis of prion diseases. We are able to determine the influence of both host-dependent factors (connectivity, cell density, protein synthesis rate, and cell death) and strain-dependent factors (cell tropism, virulence, and replication rate). We use a model based on a linked system of differential equations on a lattice to explore how the regional distribution of central nervous system pathology in Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia relates to each of these factors. The model then is used to make qualitative predictions about the pathology for two possible hypothetical triggers of neuronal loss in prion diseases. Pathological progression in overexpressing mouse models has been shown to depend on the site of initial infection. The model allows us to compare the pathologies resulting from different inoculation routes.</jats:p> Mapping the parameters of prion-induced neuropathology Proceedings of the National Academy of Sciences |
| spellingShingle | Stumpf, Michael P. H., Krakauer, David C., Proceedings of the National Academy of Sciences, Mapping the parameters of prion-induced neuropathology, Multidisciplinary |
| title | Mapping the parameters of prion-induced neuropathology |
| title_full | Mapping the parameters of prion-induced neuropathology |
| title_fullStr | Mapping the parameters of prion-induced neuropathology |
| title_full_unstemmed | Mapping the parameters of prion-induced neuropathology |
| title_short | Mapping the parameters of prion-induced neuropathology |
| title_sort | mapping the parameters of prion-induced neuropathology |
| title_unstemmed | Mapping the parameters of prion-induced neuropathology |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.180317097 |