Eintrag weiter verarbeiten
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 114, 2017, 17 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan |
|---|---|
| author |
Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan |
| spellingShingle |
Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan Proceedings of the National Academy of Sciences Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain Multidisciplinary |
| author_sort |
reimers, catharina |
| spelling |
Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1616232114 <jats:title>Significance</jats:title> <jats:p> Marine cone snails provide one of the highest toxin diversities among venomous animals, the conotoxins, which often target ion channels. In addition, cone snail venoms contain short conopeptides, the molecular targets of which are mostly unknown. We identified a new conopeptide from the venom of the cone snail <jats:italic>Conus textile</jats:italic> that targets the proton-gated ion channel ASIC3, which detects painful acidosis. This peptide belongs to the subgroup of cono-RFamides and potentiates ASIC3 currents, thereby increasing the excitability of nociceptors. Injection of the cono-RFamide in mice muscle enhanced acid-induced muscle pain. Our results thus identify ASIC3 as the first molecular target of cono-RFamides. These findings underline the role of ASIC3 in pain perception and the importance of nontoxic venom components. </jats:p> Identification of a cono-RFamide from the venom of <i>Conus textile</i> that targets ASIC3 and enhances muscle pain Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.1616232114 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE2MTYyMzIxMTQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE2MTYyMzIxMTQ |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
| imprint |
Proceedings of the National Academy of Sciences, 2017 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2017 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
reimers2017identificationofaconorfamidefromthevenomofconustextilethattargetsasic3andenhancesmusclepain |
| publishDateSort |
2017 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_unstemmed |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_full |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_fullStr |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_full_unstemmed |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_short |
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_sort |
identification of a cono-rfamide from the venom of
<i>conus textile</i>
that targets asic3 and enhances muscle pain |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1616232114 |
| publishDate |
2017 |
| physical |
|
| description |
<jats:title>Significance</jats:title>
<jats:p>
Marine cone snails provide one of the highest toxin diversities among venomous animals, the conotoxins, which often target ion channels. In addition, cone snail venoms contain short conopeptides, the molecular targets of which are mostly unknown. We identified a new conopeptide from the venom of the cone snail
<jats:italic>Conus textile</jats:italic>
that targets the proton-gated ion channel ASIC3, which detects painful acidosis. This peptide belongs to the subgroup of cono-RFamides and potentiates ASIC3 currents, thereby increasing the excitability of nociceptors. Injection of the cono-RFamide in mice muscle enhanced acid-induced muscle pain. Our results thus identify ASIC3 as the first molecular target of cono-RFamides. These findings underline the role of ASIC3 in pain perception and the importance of nontoxic venom components.
</jats:p> |
| container_issue |
17 |
| container_start_page |
0 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
114 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344329636806660 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:05:27.755Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Identification+of+a+cono-RFamide+from+the+venom+of++++++++++++Conus+textile++++++++++++that+targets+ASIC3+and+enhances+muscle+pain&rft.date=2017-04-25&genre=article&issn=1091-6490&volume=114&issue=17&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Identification+of+a+cono-RFamide+from+the+venom+of%0A++++++++++++%3Ci%3EConus+textile%3C%2Fi%3E%0A++++++++++++that+targets+ASIC3+and+enhances+muscle+pain&aulast=Gr%C3%BCnder&aufirst=Stefan&rft_id=info%3Adoi%2F10.1073%2Fpnas.1616232114&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344329636806660 |
| author | Reimers, Catharina, Lee, Cheng-Han, Kalbacher, Hubert, Tian, Yuemin, Hung, Chih-Hsien, Schmidt, Axel, Prokop, Lea, Kauferstein, Silke, Mebs, Dietrich, Chen, Chih-Cheng, Gründer, Stefan |
| author_facet | Reimers, Catharina, Lee, Cheng-Han, Kalbacher, Hubert, Tian, Yuemin, Hung, Chih-Hsien, Schmidt, Axel, Prokop, Lea, Kauferstein, Silke, Mebs, Dietrich, Chen, Chih-Cheng, Gründer, Stefan, Reimers, Catharina, Lee, Cheng-Han, Kalbacher, Hubert, Tian, Yuemin, Hung, Chih-Hsien, Schmidt, Axel, Prokop, Lea, Kauferstein, Silke, Mebs, Dietrich, Chen, Chih-Cheng, Gründer, Stefan |
| author_sort | reimers, catharina |
| container_issue | 17 |
| container_start_page | 0 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 114 |
| description | <jats:title>Significance</jats:title> <jats:p> Marine cone snails provide one of the highest toxin diversities among venomous animals, the conotoxins, which often target ion channels. In addition, cone snail venoms contain short conopeptides, the molecular targets of which are mostly unknown. We identified a new conopeptide from the venom of the cone snail <jats:italic>Conus textile</jats:italic> that targets the proton-gated ion channel ASIC3, which detects painful acidosis. This peptide belongs to the subgroup of cono-RFamides and potentiates ASIC3 currents, thereby increasing the excitability of nociceptors. Injection of the cono-RFamide in mice muscle enhanced acid-induced muscle pain. Our results thus identify ASIC3 as the first molecular target of cono-RFamides. These findings underline the role of ASIC3 in pain perception and the importance of nontoxic venom components. </jats:p> |
| doi_str_mv | 10.1073/pnas.1616232114 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE2MTYyMzIxMTQ |
| imprint | Proceedings of the National Academy of Sciences, 2017 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2017 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:05:27.755Z |
| match_str | reimers2017identificationofaconorfamidefromthevenomofconustextilethattargetsasic3andenhancesmusclepain |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Reimers, Catharina Lee, Cheng-Han Kalbacher, Hubert Tian, Yuemin Hung, Chih-Hsien Schmidt, Axel Prokop, Lea Kauferstein, Silke Mebs, Dietrich Chen, Chih-Cheng Gründer, Stefan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1616232114 <jats:title>Significance</jats:title> <jats:p> Marine cone snails provide one of the highest toxin diversities among venomous animals, the conotoxins, which often target ion channels. In addition, cone snail venoms contain short conopeptides, the molecular targets of which are mostly unknown. We identified a new conopeptide from the venom of the cone snail <jats:italic>Conus textile</jats:italic> that targets the proton-gated ion channel ASIC3, which detects painful acidosis. This peptide belongs to the subgroup of cono-RFamides and potentiates ASIC3 currents, thereby increasing the excitability of nociceptors. Injection of the cono-RFamide in mice muscle enhanced acid-induced muscle pain. Our results thus identify ASIC3 as the first molecular target of cono-RFamides. These findings underline the role of ASIC3 in pain perception and the importance of nontoxic venom components. </jats:p> Identification of a cono-RFamide from the venom of <i>Conus textile</i> that targets ASIC3 and enhances muscle pain Proceedings of the National Academy of Sciences |
| spellingShingle | Reimers, Catharina, Lee, Cheng-Han, Kalbacher, Hubert, Tian, Yuemin, Hung, Chih-Hsien, Schmidt, Axel, Prokop, Lea, Kauferstein, Silke, Mebs, Dietrich, Chen, Chih-Cheng, Gründer, Stefan, Proceedings of the National Academy of Sciences, Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain, Multidisciplinary |
| title | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_full | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_fullStr | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_full_unstemmed | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_short | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| title_sort | identification of a cono-rfamide from the venom of <i>conus textile</i> that targets asic3 and enhances muscle pain |
| title_unstemmed | Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1616232114 |