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Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 101, 2004, 14, S. 4827-4832 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie |
|---|---|
| author |
Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie |
| spellingShingle |
Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie Proceedings of the National Academy of Sciences Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor Multidisciplinary |
| author_sort |
derouet, damien |
| spelling |
Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0306178101 <jats:p> A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The <jats:italic>np</jats:italic> gene is localized in tandem with the <jats:italic>cardiotrophin</jats:italic> - <jats:italic>1</jats:italic> gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-α component (CNTFRα), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRα, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the <jats:italic>in vitro</jats:italic> survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRα, with important implications for murine nervous system development. </jats:p> Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor Proceedings of the National Academy of Sciences |
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| title |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_unstemmed |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_full |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_fullStr |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_full_unstemmed |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_short |
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_sort |
neuropoietin, a new il-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.0306178101 |
| publishDate |
2004 |
| physical |
4827-4832 |
| description |
<jats:p>
A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The
<jats:italic>np</jats:italic>
gene is localized in tandem with the
<jats:italic>cardiotrophin</jats:italic>
-
<jats:italic>1</jats:italic>
gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-α component (CNTFRα), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRα, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the
<jats:italic>in vitro</jats:italic>
survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRα, with important implications for murine nervous system development.
</jats:p> |
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| author | Derouet, Damien, Rousseau, François, Alfonsi, Fabienne, Froger, Josy, Hermann, Jacques, Barbier, Fabien, Perret, David, Diveu, Caroline, Guillet, Catherine, Preisser, Laurence, Dumont, Agnès, Barbado, Maud, Morel, Alain, deLapeyrière, Odile, Gascan, Hugues, Chevalier, Sylvie |
| author_facet | Derouet, Damien, Rousseau, François, Alfonsi, Fabienne, Froger, Josy, Hermann, Jacques, Barbier, Fabien, Perret, David, Diveu, Caroline, Guillet, Catherine, Preisser, Laurence, Dumont, Agnès, Barbado, Maud, Morel, Alain, deLapeyrière, Odile, Gascan, Hugues, Chevalier, Sylvie, Derouet, Damien, Rousseau, François, Alfonsi, Fabienne, Froger, Josy, Hermann, Jacques, Barbier, Fabien, Perret, David, Diveu, Caroline, Guillet, Catherine, Preisser, Laurence, Dumont, Agnès, Barbado, Maud, Morel, Alain, deLapeyrière, Odile, Gascan, Hugues, Chevalier, Sylvie |
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| description | <jats:p> A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The <jats:italic>np</jats:italic> gene is localized in tandem with the <jats:italic>cardiotrophin</jats:italic> - <jats:italic>1</jats:italic> gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-α component (CNTFRα), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRα, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the <jats:italic>in vitro</jats:italic> survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRα, with important implications for murine nervous system development. </jats:p> |
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| imprint_str_mv | Proceedings of the National Academy of Sciences, 2004 |
| institution | DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| spelling | Derouet, Damien Rousseau, François Alfonsi, Fabienne Froger, Josy Hermann, Jacques Barbier, Fabien Perret, David Diveu, Caroline Guillet, Catherine Preisser, Laurence Dumont, Agnès Barbado, Maud Morel, Alain deLapeyrière, Odile Gascan, Hugues Chevalier, Sylvie 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0306178101 <jats:p> A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The <jats:italic>np</jats:italic> gene is localized in tandem with the <jats:italic>cardiotrophin</jats:italic> - <jats:italic>1</jats:italic> gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-α component (CNTFRα), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRα, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the <jats:italic>in vitro</jats:italic> survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRα, with important implications for murine nervous system development. </jats:p> Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor Proceedings of the National Academy of Sciences |
| spellingShingle | Derouet, Damien, Rousseau, François, Alfonsi, Fabienne, Froger, Josy, Hermann, Jacques, Barbier, Fabien, Perret, David, Diveu, Caroline, Guillet, Catherine, Preisser, Laurence, Dumont, Agnès, Barbado, Maud, Morel, Alain, deLapeyrière, Odile, Gascan, Hugues, Chevalier, Sylvie, Proceedings of the National Academy of Sciences, Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor, Multidisciplinary |
| title | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_full | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_fullStr | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_full_unstemmed | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_short | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_sort | neuropoietin, a new il-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| title_unstemmed | Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.0306178101 |