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Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , , , |
| In: | Proceedings of the National Academy of Sciences, 105, 2008, 23, S. 8136-8141 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong |
|---|---|
| author |
Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong |
| spellingShingle |
Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong Proceedings of the National Academy of Sciences Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex Multidisciplinary |
| author_sort |
low, lawrence k. |
| spelling |
Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0803849105 <jats:p>Neurons in the developing CNS tend to send out long axon collaterals to multiple target areas. For these neurons to attain specific connections, some of their axon collaterals are subsequently pruned—a process called stereotyped axon pruning. One of the most striking examples of stereotyped pruning in the CNS is the pruning of corticospinal tract (CST) axons. The long CST collaterals from layer V neurons of the visual and motor cortices are differentially pruned during development. Here we demonstrate that select plexins and neuropilins, which serve as coreceptors for semaphorins, are expressed in visual cortical neurons at the time when CST axon collaterals are stereotypically pruned. By analyzing mutant mice, we find that the pruning of visual, but not motor, CST axon collaterals depends on plexin-A3, plexin-A4, and neuropilin-2. Expression pattern study suggests that Sema3F is a candidate local cue for the pruning of visual CST axons. Using electron microscopic analysis, we also show that visual CST axon collaterals form synaptic contacts in the spinal cord before pruning and that the unpruned collaterals in adult mutant mice are unmyelinated and maintain their synaptic contacts. Our results indicate that the stereotyped pruning of the visual and motor CST axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.</jats:p> Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex Proceedings of the National Academy of Sciences |
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| title |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_unstemmed |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_full |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_fullStr |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_full_unstemmed |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_short |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_sort |
plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.0803849105 |
| publishDate |
2008 |
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8136-8141 |
| description |
<jats:p>Neurons in the developing CNS tend to send out long axon collaterals to multiple target areas. For these neurons to attain specific connections, some of their axon collaterals are subsequently pruned—a process called stereotyped axon pruning. One of the most striking examples of stereotyped pruning in the CNS is the pruning of corticospinal tract (CST) axons. The long CST collaterals from layer V neurons of the visual and motor cortices are differentially pruned during development. Here we demonstrate that select plexins and neuropilins, which serve as coreceptors for semaphorins, are expressed in visual cortical neurons at the time when CST axon collaterals are stereotypically pruned. By analyzing mutant mice, we find that the pruning of visual, but not motor, CST axon collaterals depends on plexin-A3, plexin-A4, and neuropilin-2. Expression pattern study suggests that Sema3F is a candidate local cue for the pruning of visual CST axons. Using electron microscopic analysis, we also show that visual CST axon collaterals form synaptic contacts in the spinal cord before pruning and that the unpruned collaterals in adult mutant mice are unmyelinated and maintain their synaptic contacts. Our results indicate that the stereotyped pruning of the visual and motor CST axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.</jats:p> |
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| author | Low, Lawrence K., Liu, Xiao-Bo, Faulkner, Regina L., Coble, Jeffrey, Cheng, Hwai-Jong |
| author_facet | Low, Lawrence K., Liu, Xiao-Bo, Faulkner, Regina L., Coble, Jeffrey, Cheng, Hwai-Jong, Low, Lawrence K., Liu, Xiao-Bo, Faulkner, Regina L., Coble, Jeffrey, Cheng, Hwai-Jong |
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| description | <jats:p>Neurons in the developing CNS tend to send out long axon collaterals to multiple target areas. For these neurons to attain specific connections, some of their axon collaterals are subsequently pruned—a process called stereotyped axon pruning. One of the most striking examples of stereotyped pruning in the CNS is the pruning of corticospinal tract (CST) axons. The long CST collaterals from layer V neurons of the visual and motor cortices are differentially pruned during development. Here we demonstrate that select plexins and neuropilins, which serve as coreceptors for semaphorins, are expressed in visual cortical neurons at the time when CST axon collaterals are stereotypically pruned. By analyzing mutant mice, we find that the pruning of visual, but not motor, CST axon collaterals depends on plexin-A3, plexin-A4, and neuropilin-2. Expression pattern study suggests that Sema3F is a candidate local cue for the pruning of visual CST axons. Using electron microscopic analysis, we also show that visual CST axon collaterals form synaptic contacts in the spinal cord before pruning and that the unpruned collaterals in adult mutant mice are unmyelinated and maintain their synaptic contacts. Our results indicate that the stereotyped pruning of the visual and motor CST axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.</jats:p> |
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| spelling | Low, Lawrence K. Liu, Xiao-Bo Faulkner, Regina L. Coble, Jeffrey Cheng, Hwai-Jong 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0803849105 <jats:p>Neurons in the developing CNS tend to send out long axon collaterals to multiple target areas. For these neurons to attain specific connections, some of their axon collaterals are subsequently pruned—a process called stereotyped axon pruning. One of the most striking examples of stereotyped pruning in the CNS is the pruning of corticospinal tract (CST) axons. The long CST collaterals from layer V neurons of the visual and motor cortices are differentially pruned during development. Here we demonstrate that select plexins and neuropilins, which serve as coreceptors for semaphorins, are expressed in visual cortical neurons at the time when CST axon collaterals are stereotypically pruned. By analyzing mutant mice, we find that the pruning of visual, but not motor, CST axon collaterals depends on plexin-A3, plexin-A4, and neuropilin-2. Expression pattern study suggests that Sema3F is a candidate local cue for the pruning of visual CST axons. Using electron microscopic analysis, we also show that visual CST axon collaterals form synaptic contacts in the spinal cord before pruning and that the unpruned collaterals in adult mutant mice are unmyelinated and maintain their synaptic contacts. Our results indicate that the stereotyped pruning of the visual and motor CST axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex.</jats:p> Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex Proceedings of the National Academy of Sciences |
| spellingShingle | Low, Lawrence K., Liu, Xiao-Bo, Faulkner, Regina L., Coble, Jeffrey, Cheng, Hwai-Jong, Proceedings of the National Academy of Sciences, Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex, Multidisciplinary |
| title | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_full | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_fullStr | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_full_unstemmed | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_short | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_sort | plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| title_unstemmed | Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.0803849105 |