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Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients
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| Zeitschriftentitel: | International Journal of Dermatology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | International Journal of Dermatology, 37, 1998, 4, S. 293-298 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. |
|---|---|
| author |
Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. |
| spellingShingle |
Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. International Journal of Dermatology Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients Dermatology |
| author_sort |
smith md, kathleen j. |
| spelling |
Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. 0011-9059 1365-4632 Wiley Dermatology http://dx.doi.org/10.1046/j.1365-4362.1998.00272.x <jats:p> <jats:italic>Background</jats:italic> Post‐infection vaccination with human immunodeficiency virus type 1</jats:p><jats:p>(HIV‐1) specific antigens has been hypothesized as a mechanism for generating a more effective immune response to the HIV‐1 virus. Cutaneous reactions at the site of immunization may provide information on the pattern of immune activation induced by the vaccine.</jats:p><jats:p> <jats:italic>Objective</jats:italic> To evaluate exaggerated local cutaneous reactions in eight HIV‐1+ patients enrolled in a phase I and II gp160 vaccine study.</jats:p><jats:p> <jats:italic>Methods</jats:italic> Cutaneous biopsy specimens were obtained and evaluated using routine histologic, immunofluorescence, and immunohistochemical techniques.</jats:p><jats:p> <jats:italic>Results</jats:italic> A mononuclear cell infiltrate with tissue eosinophilia, in some cases forming flame figures, was present on histologic sections. There was no evidence of immune complex deposition. Activated T‐helper cells formed a major portion of the mononuclear cell infiltrate.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> A delayed‐type hypersensitivity reaction, mediated by T cells with a T‐helper 2 cytokine pattern, was favored by clinical and histologic features. The most likely antigen stimulating this reaction is residual lepidopteran used in the preparation of the vaccine; however, baculovirus antigens may also play a role. In addition, the adjuvant, aluminum phosphate, as well as the underlying patterns of immune dysregulation present in HIV‐1+ patients, may potentiate these reactions.</jats:p> Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients International Journal of Dermatology |
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| title |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_unstemmed |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_full |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_fullStr |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_full_unstemmed |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_short |
Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_sort |
cutaneous reactions at the site of post‐infection gp160 vaccination therapy in hiv‐1+ patients |
| topic |
Dermatology |
| url |
http://dx.doi.org/10.1046/j.1365-4362.1998.00272.x |
| publishDate |
1998 |
| physical |
293-298 |
| description |
<jats:p> <jats:italic>Background</jats:italic> Post‐infection vaccination with human immunodeficiency virus type 1</jats:p><jats:p>(HIV‐1) specific antigens has been hypothesized as a mechanism for generating a more effective immune response to the HIV‐1 virus. Cutaneous reactions at the site of immunization may provide information on the pattern of immune activation induced by the vaccine.</jats:p><jats:p> <jats:italic>Objective</jats:italic> To evaluate exaggerated local cutaneous reactions in eight HIV‐1+ patients enrolled in a phase I and II gp160 vaccine study.</jats:p><jats:p> <jats:italic>Methods</jats:italic> Cutaneous biopsy specimens were obtained and evaluated using routine histologic, immunofluorescence, and immunohistochemical techniques.</jats:p><jats:p> <jats:italic>Results</jats:italic> A mononuclear cell infiltrate with tissue eosinophilia, in some cases forming flame figures, was present on histologic sections. There was no evidence of immune complex deposition. Activated T‐helper cells formed a major portion of the mononuclear cell infiltrate.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> A delayed‐type hypersensitivity reaction, mediated by T cells with a T‐helper 2 cytokine pattern, was favored by clinical and histologic features. The most likely antigen stimulating this reaction is residual lepidopteran used in the preparation of the vaccine; however, baculovirus antigens may also play a role. In addition, the adjuvant, aluminum phosphate, as well as the underlying patterns of immune dysregulation present in HIV‐1+ patients, may potentiate these reactions.</jats:p> |
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| author | Smith MD, Kathleen J., Skelton MD, Henry G., Ruiz MD, Nancy, Samlaska MD, Kurt, Wagner MD, Kenneth F. |
| author_facet | Smith MD, Kathleen J., Skelton MD, Henry G., Ruiz MD, Nancy, Samlaska MD, Kurt, Wagner MD, Kenneth F., Smith MD, Kathleen J., Skelton MD, Henry G., Ruiz MD, Nancy, Samlaska MD, Kurt, Wagner MD, Kenneth F. |
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| description | <jats:p> <jats:italic>Background</jats:italic> Post‐infection vaccination with human immunodeficiency virus type 1</jats:p><jats:p>(HIV‐1) specific antigens has been hypothesized as a mechanism for generating a more effective immune response to the HIV‐1 virus. Cutaneous reactions at the site of immunization may provide information on the pattern of immune activation induced by the vaccine.</jats:p><jats:p> <jats:italic>Objective</jats:italic> To evaluate exaggerated local cutaneous reactions in eight HIV‐1+ patients enrolled in a phase I and II gp160 vaccine study.</jats:p><jats:p> <jats:italic>Methods</jats:italic> Cutaneous biopsy specimens were obtained and evaluated using routine histologic, immunofluorescence, and immunohistochemical techniques.</jats:p><jats:p> <jats:italic>Results</jats:italic> A mononuclear cell infiltrate with tissue eosinophilia, in some cases forming flame figures, was present on histologic sections. There was no evidence of immune complex deposition. Activated T‐helper cells formed a major portion of the mononuclear cell infiltrate.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> A delayed‐type hypersensitivity reaction, mediated by T cells with a T‐helper 2 cytokine pattern, was favored by clinical and histologic features. The most likely antigen stimulating this reaction is residual lepidopteran used in the preparation of the vaccine; however, baculovirus antigens may also play a role. In addition, the adjuvant, aluminum phosphate, as well as the underlying patterns of immune dysregulation present in HIV‐1+ patients, may potentiate these reactions.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Smith MD, Kathleen J. Skelton MD, Henry G. Ruiz MD, Nancy Samlaska MD, Kurt Wagner MD, Kenneth F. 0011-9059 1365-4632 Wiley Dermatology http://dx.doi.org/10.1046/j.1365-4362.1998.00272.x <jats:p> <jats:italic>Background</jats:italic> Post‐infection vaccination with human immunodeficiency virus type 1</jats:p><jats:p>(HIV‐1) specific antigens has been hypothesized as a mechanism for generating a more effective immune response to the HIV‐1 virus. Cutaneous reactions at the site of immunization may provide information on the pattern of immune activation induced by the vaccine.</jats:p><jats:p> <jats:italic>Objective</jats:italic> To evaluate exaggerated local cutaneous reactions in eight HIV‐1+ patients enrolled in a phase I and II gp160 vaccine study.</jats:p><jats:p> <jats:italic>Methods</jats:italic> Cutaneous biopsy specimens were obtained and evaluated using routine histologic, immunofluorescence, and immunohistochemical techniques.</jats:p><jats:p> <jats:italic>Results</jats:italic> A mononuclear cell infiltrate with tissue eosinophilia, in some cases forming flame figures, was present on histologic sections. There was no evidence of immune complex deposition. Activated T‐helper cells formed a major portion of the mononuclear cell infiltrate.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> A delayed‐type hypersensitivity reaction, mediated by T cells with a T‐helper 2 cytokine pattern, was favored by clinical and histologic features. The most likely antigen stimulating this reaction is residual lepidopteran used in the preparation of the vaccine; however, baculovirus antigens may also play a role. In addition, the adjuvant, aluminum phosphate, as well as the underlying patterns of immune dysregulation present in HIV‐1+ patients, may potentiate these reactions.</jats:p> Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients International Journal of Dermatology |
| spellingShingle | Smith MD, Kathleen J., Skelton MD, Henry G., Ruiz MD, Nancy, Samlaska MD, Kurt, Wagner MD, Kenneth F., International Journal of Dermatology, Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients, Dermatology |
| title | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_full | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_fullStr | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_full_unstemmed | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_short | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| title_sort | cutaneous reactions at the site of post‐infection gp160 vaccination therapy in hiv‐1+ patients |
| title_unstemmed | Cutaneous reactions at the site of post‐infection gp160 vaccination therapy in HIV‐1+ patients |
| topic | Dermatology |
| url | http://dx.doi.org/10.1046/j.1365-4362.1998.00272.x |