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Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus
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| Zeitschriftentitel: | International Journal of Dermatology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | International Journal of Dermatology, 37, 1998, 4, S. 260-262 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. |
|---|---|
| author |
Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. |
| spellingShingle |
Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. International Journal of Dermatology Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus Dermatology |
| author_sort |
boyd md, alan s. |
| spelling |
Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. 0011-9059 1365-4632 Wiley Dermatology http://dx.doi.org/10.1046/j.1365-4362.1998.00239.x <jats:p> <jats:italic>Background</jats:italic> Lichen planus is a papulosquamous dermatosis which has recently been linked to infection with hepatitis C virus. It is unclear whether or not viral antigens may be present in the cutaneous lesions of lichen planus.</jats:p><jats:p> <jats:italic>Materials and methods</jats:italic>Twenty‐five paraffin‐embedded samples of glabrous lichen planus were evaluated using immunoperoxidase staining for the presence of hepatitis C virions. Control tissues consisted of hepatitis C‐infected hepatic tissue (<jats:italic>n</jats:italic> = 2), normal hepatic tissue (<jats:italic>n</jats:italic> = 2), normal human skin (<jats:italic>n</jats:italic> = 1), and two cutaneous biopsies of lichen planus from persons known to be infected with hepatitis C.</jats:p><jats:p> <jats:italic>Results</jats:italic> The sections of hepatitis C‐infected liver tissue stained positive for hepatitis C virions. The 25 biopsies of glabrous lichen planus, the two biopsies of lichen planus from hepatitis C patients, the two sections of normal liver, and the one normal skin sample all failed to take up the stain.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> Cutaneous lesions of lichen planus are more probably reactive to the underlying infection than a manifestation of skin involvement by this disease. This theory is supported by the histologic findings in a lichenoid drug eruption, which are virtually identical to those of idiopathic lichen planus. Insufficient sensitivity by the immunoperoxidase procedure used is a possible explanation for our results; however, it appears more probable that no virus exists at the sites of cutaneous involvement.</jats:p> Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus International Journal of Dermatology |
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1998 |
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International Journal of Dermatology |
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49 |
| title |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_unstemmed |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_full |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_fullStr |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_full_unstemmed |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_short |
Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_sort |
immunoperoxidase evaluation of lichen planus biopsies for hepatitis c virus |
| topic |
Dermatology |
| url |
http://dx.doi.org/10.1046/j.1365-4362.1998.00239.x |
| publishDate |
1998 |
| physical |
260-262 |
| description |
<jats:p> <jats:italic>Background</jats:italic> Lichen planus is a papulosquamous dermatosis which has recently been linked to infection with hepatitis C virus. It is unclear whether or not viral antigens may be present in the cutaneous lesions of lichen planus.</jats:p><jats:p> <jats:italic>Materials and methods</jats:italic>Twenty‐five paraffin‐embedded samples of glabrous lichen planus were evaluated using immunoperoxidase staining for the presence of hepatitis C virions. Control tissues consisted of hepatitis C‐infected hepatic tissue (<jats:italic>n</jats:italic> = 2), normal hepatic tissue (<jats:italic>n</jats:italic> = 2), normal human skin (<jats:italic>n</jats:italic> = 1), and two cutaneous biopsies of lichen planus from persons known to be infected with hepatitis C.</jats:p><jats:p> <jats:italic>Results</jats:italic> The sections of hepatitis C‐infected liver tissue stained positive for hepatitis C virions. The 25 biopsies of glabrous lichen planus, the two biopsies of lichen planus from hepatitis C patients, the two sections of normal liver, and the one normal skin sample all failed to take up the stain.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> Cutaneous lesions of lichen planus are more probably reactive to the underlying infection than a manifestation of skin involvement by this disease. This theory is supported by the histologic findings in a lichenoid drug eruption, which are virtually identical to those of idiopathic lichen planus. Insufficient sensitivity by the immunoperoxidase procedure used is a possible explanation for our results; however, it appears more probable that no virus exists at the sites of cutaneous involvement.</jats:p> |
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| author | Boyd MD, Alan S., Nanney PhD, Lillian B., King Jr MD, PhD, Lloyd E. |
| author_facet | Boyd MD, Alan S., Nanney PhD, Lillian B., King Jr MD, PhD, Lloyd E., Boyd MD, Alan S., Nanney PhD, Lillian B., King Jr MD, PhD, Lloyd E. |
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| description | <jats:p> <jats:italic>Background</jats:italic> Lichen planus is a papulosquamous dermatosis which has recently been linked to infection with hepatitis C virus. It is unclear whether or not viral antigens may be present in the cutaneous lesions of lichen planus.</jats:p><jats:p> <jats:italic>Materials and methods</jats:italic>Twenty‐five paraffin‐embedded samples of glabrous lichen planus were evaluated using immunoperoxidase staining for the presence of hepatitis C virions. Control tissues consisted of hepatitis C‐infected hepatic tissue (<jats:italic>n</jats:italic> = 2), normal hepatic tissue (<jats:italic>n</jats:italic> = 2), normal human skin (<jats:italic>n</jats:italic> = 1), and two cutaneous biopsies of lichen planus from persons known to be infected with hepatitis C.</jats:p><jats:p> <jats:italic>Results</jats:italic> The sections of hepatitis C‐infected liver tissue stained positive for hepatitis C virions. The 25 biopsies of glabrous lichen planus, the two biopsies of lichen planus from hepatitis C patients, the two sections of normal liver, and the one normal skin sample all failed to take up the stain.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> Cutaneous lesions of lichen planus are more probably reactive to the underlying infection than a manifestation of skin involvement by this disease. This theory is supported by the histologic findings in a lichenoid drug eruption, which are virtually identical to those of idiopathic lichen planus. Insufficient sensitivity by the immunoperoxidase procedure used is a possible explanation for our results; however, it appears more probable that no virus exists at the sites of cutaneous involvement.</jats:p> |
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| imprint_str_mv | Wiley, 1998 |
| institution | DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | Boyd MD, Alan S. Nanney PhD, Lillian B. King Jr MD, PhD, Lloyd E. 0011-9059 1365-4632 Wiley Dermatology http://dx.doi.org/10.1046/j.1365-4362.1998.00239.x <jats:p> <jats:italic>Background</jats:italic> Lichen planus is a papulosquamous dermatosis which has recently been linked to infection with hepatitis C virus. It is unclear whether or not viral antigens may be present in the cutaneous lesions of lichen planus.</jats:p><jats:p> <jats:italic>Materials and methods</jats:italic>Twenty‐five paraffin‐embedded samples of glabrous lichen planus were evaluated using immunoperoxidase staining for the presence of hepatitis C virions. Control tissues consisted of hepatitis C‐infected hepatic tissue (<jats:italic>n</jats:italic> = 2), normal hepatic tissue (<jats:italic>n</jats:italic> = 2), normal human skin (<jats:italic>n</jats:italic> = 1), and two cutaneous biopsies of lichen planus from persons known to be infected with hepatitis C.</jats:p><jats:p> <jats:italic>Results</jats:italic> The sections of hepatitis C‐infected liver tissue stained positive for hepatitis C virions. The 25 biopsies of glabrous lichen planus, the two biopsies of lichen planus from hepatitis C patients, the two sections of normal liver, and the one normal skin sample all failed to take up the stain.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic> Cutaneous lesions of lichen planus are more probably reactive to the underlying infection than a manifestation of skin involvement by this disease. This theory is supported by the histologic findings in a lichenoid drug eruption, which are virtually identical to those of idiopathic lichen planus. Insufficient sensitivity by the immunoperoxidase procedure used is a possible explanation for our results; however, it appears more probable that no virus exists at the sites of cutaneous involvement.</jats:p> Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus International Journal of Dermatology |
| spellingShingle | Boyd MD, Alan S., Nanney PhD, Lillian B., King Jr MD, PhD, Lloyd E., International Journal of Dermatology, Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus, Dermatology |
| title | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_full | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_fullStr | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_full_unstemmed | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_short | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| title_sort | immunoperoxidase evaluation of lichen planus biopsies for hepatitis c virus |
| title_unstemmed | Immunoperoxidase evaluation of lichen planus biopsies for hepatitis C virus |
| topic | Dermatology |
| url | http://dx.doi.org/10.1046/j.1365-4362.1998.00239.x |