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Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice
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| Zeitschriftentitel: | Parasite Immunology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Parasite Immunology, 21, 1999, 4, S. 169-176 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE |
|---|---|
| author |
COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE |
| spellingShingle |
COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE Parasite Immunology Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice Immunology Parasitology |
| author_sort |
cooke, anne |
| spelling |
COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE 0141-9838 1365-3024 Wiley Immunology Parasitology http://dx.doi.org/10.1046/j.1365-3024.1999.00213.x <jats:p> <jats:italic>The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of </jats:italic>Schistosoma mansoni<jats:italic> infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 response in </jats:italic>S.mansoni<jats:italic> infected mice has been shown to influence the response to other infectious agents or antigens. We therefore determined whether infection with </jats:italic>S.mansoni<jats:italic> could influence the spontaneous incidence of insulin dependent diabetes mellitus (IDDM) in NOD mice. Infection with this helminth significantly reduced the spontaneous incidence of IDDM. IDDM was also prevented by injecting parasite eggs alone. Because until relatively recently humans might expect to succumb to a variety of infectious agents, the current freedom from infection might permit the expression of a genetic predisposition to autoimmune pathology and be responsible for the increased incidence of IDDM.</jats:italic></jats:p> Infection with <i>Schistosoma mansoni</i> prevents insulin dependent diabetes mellitus in non‐obese diabetic mice Parasite Immunology |
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| title |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_unstemmed |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_full |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_fullStr |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_full_unstemmed |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_short |
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_sort |
infection with <i>schistosoma mansoni</i> prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| topic |
Immunology Parasitology |
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http://dx.doi.org/10.1046/j.1365-3024.1999.00213.x |
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1999 |
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169-176 |
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<jats:p> <jats:italic>The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of </jats:italic>Schistosoma mansoni<jats:italic> infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 response in </jats:italic>S.mansoni<jats:italic> infected mice has been shown to influence the response to other infectious agents or antigens. We therefore determined whether infection with </jats:italic>S.mansoni<jats:italic> could influence the spontaneous incidence of insulin dependent diabetes mellitus (IDDM) in NOD mice. Infection with this helminth significantly reduced the spontaneous incidence of IDDM. IDDM was also prevented by injecting parasite eggs alone. Because until relatively recently humans might expect to succumb to a variety of infectious agents, the current freedom from infection might permit the expression of a genetic predisposition to autoimmune pathology and be responsible for the increased incidence of IDDM.</jats:italic></jats:p> |
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| author | COOKE, ANNE, TONKS, PAUL, JONES, FRANCIS M., O'SHEA, HELEN, HUTCHINGS, PATRICIA, FULFORD, ANTHONY J.C., DUNNE |
| author_facet | COOKE, ANNE, TONKS, PAUL, JONES, FRANCIS M., O'SHEA, HELEN, HUTCHINGS, PATRICIA, FULFORD, ANTHONY J.C., DUNNE, COOKE, ANNE, TONKS, PAUL, JONES, FRANCIS M., O'SHEA, HELEN, HUTCHINGS, PATRICIA, FULFORD, ANTHONY J.C., DUNNE |
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| description | <jats:p> <jats:italic>The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of </jats:italic>Schistosoma mansoni<jats:italic> infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 response in </jats:italic>S.mansoni<jats:italic> infected mice has been shown to influence the response to other infectious agents or antigens. We therefore determined whether infection with </jats:italic>S.mansoni<jats:italic> could influence the spontaneous incidence of insulin dependent diabetes mellitus (IDDM) in NOD mice. Infection with this helminth significantly reduced the spontaneous incidence of IDDM. IDDM was also prevented by injecting parasite eggs alone. Because until relatively recently humans might expect to succumb to a variety of infectious agents, the current freedom from infection might permit the expression of a genetic predisposition to autoimmune pathology and be responsible for the increased incidence of IDDM.</jats:italic></jats:p> |
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| imprint_str_mv | Wiley, 1999 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
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| spelling | COOKE, ANNE TONKS, PAUL JONES, FRANCIS M. O'SHEA, HELEN HUTCHINGS, PATRICIA FULFORD, ANTHONY J.C. DUNNE 0141-9838 1365-3024 Wiley Immunology Parasitology http://dx.doi.org/10.1046/j.1365-3024.1999.00213.x <jats:p> <jats:italic>The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of </jats:italic>Schistosoma mansoni<jats:italic> infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 response in </jats:italic>S.mansoni<jats:italic> infected mice has been shown to influence the response to other infectious agents or antigens. We therefore determined whether infection with </jats:italic>S.mansoni<jats:italic> could influence the spontaneous incidence of insulin dependent diabetes mellitus (IDDM) in NOD mice. Infection with this helminth significantly reduced the spontaneous incidence of IDDM. IDDM was also prevented by injecting parasite eggs alone. Because until relatively recently humans might expect to succumb to a variety of infectious agents, the current freedom from infection might permit the expression of a genetic predisposition to autoimmune pathology and be responsible for the increased incidence of IDDM.</jats:italic></jats:p> Infection with <i>Schistosoma mansoni</i> prevents insulin dependent diabetes mellitus in non‐obese diabetic mice Parasite Immunology |
| spellingShingle | COOKE, ANNE, TONKS, PAUL, JONES, FRANCIS M., O'SHEA, HELEN, HUTCHINGS, PATRICIA, FULFORD, ANTHONY J.C., DUNNE, Parasite Immunology, Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice, Immunology, Parasitology |
| title | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_full | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_fullStr | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_full_unstemmed | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_short | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_sort | infection with <i>schistosoma mansoni</i> prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| title_unstemmed | Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice |
| topic | Immunology, Parasitology |
| url | http://dx.doi.org/10.1046/j.1365-3024.1999.00213.x |