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Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats
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Zeitschriftentitel: | Journal of Neuroendocrinology |
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Personen und Körperschaften: | , , , , , , |
In: | Journal of Neuroendocrinology, 14, 2002, 8, S. 607-610 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
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Schlagwörter: |
author_facet |
Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. |
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author |
Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. |
spellingShingle |
Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. Journal of Neuroendocrinology Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats Cellular and Molecular Neuroscience Endocrine and Autonomic Systems Endocrinology Endocrinology, Diabetes and Metabolism |
author_sort |
shen, c.‐p. |
spelling |
Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. 0953-8194 1365-2826 Wiley Cellular and Molecular Neuroscience Endocrine and Autonomic Systems Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1046/j.1365-2826.2002.00825.x <jats:title>Abstract</jats:title><jats:p>We measured plasma concentrations of agouti‐related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet‐induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting‐refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.</jats:p> Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats Journal of Neuroendocrinology |
doi_str_mv |
10.1046/j.1365-2826.2002.00825.x |
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2002 |
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Wiley |
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Journal of Neuroendocrinology |
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49 |
title |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_unstemmed |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_full |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_fullStr |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_full_unstemmed |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_short |
Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_sort |
plasma agouti‐related protein level: a possible correlation with fasted and fed states in humans and rats |
topic |
Cellular and Molecular Neuroscience Endocrine and Autonomic Systems Endocrinology Endocrinology, Diabetes and Metabolism |
url |
http://dx.doi.org/10.1046/j.1365-2826.2002.00825.x |
publishDate |
2002 |
physical |
607-610 |
description |
<jats:title>Abstract</jats:title><jats:p>We measured plasma concentrations of agouti‐related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet‐induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting‐refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.</jats:p> |
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author | Shen, C.‐P., Wu, K. K., Shearman, L. P., Camacho, R., Tota, M. R., Fong, T. M., Van der Ploeg, L. H. T. |
author_facet | Shen, C.‐P., Wu, K. K., Shearman, L. P., Camacho, R., Tota, M. R., Fong, T. M., Van der Ploeg, L. H. T., Shen, C.‐P., Wu, K. K., Shearman, L. P., Camacho, R., Tota, M. R., Fong, T. M., Van der Ploeg, L. H. T. |
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container_title | Journal of Neuroendocrinology |
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description | <jats:title>Abstract</jats:title><jats:p>We measured plasma concentrations of agouti‐related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet‐induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting‐refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.</jats:p> |
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spelling | Shen, C.‐P. Wu, K. K. Shearman, L. P. Camacho, R. Tota, M. R. Fong, T. M. Van der Ploeg, L. H. T. 0953-8194 1365-2826 Wiley Cellular and Molecular Neuroscience Endocrine and Autonomic Systems Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1046/j.1365-2826.2002.00825.x <jats:title>Abstract</jats:title><jats:p>We measured plasma concentrations of agouti‐related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet‐induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting‐refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.</jats:p> Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats Journal of Neuroendocrinology |
spellingShingle | Shen, C.‐P., Wu, K. K., Shearman, L. P., Camacho, R., Tota, M. R., Fong, T. M., Van der Ploeg, L. H. T., Journal of Neuroendocrinology, Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Endocrinology, Endocrinology, Diabetes and Metabolism |
title | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_full | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_fullStr | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_full_unstemmed | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_short | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
title_sort | plasma agouti‐related protein level: a possible correlation with fasted and fed states in humans and rats |
title_unstemmed | Plasma Agouti‐Related Protein Level: A Possible Correlation with Fasted and Fed States in Humans and Rats |
topic | Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Endocrinology, Endocrinology, Diabetes and Metabolism |
url | http://dx.doi.org/10.1046/j.1365-2826.2002.00825.x |