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DNA vaccines: a review
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| Zeitschriftentitel: | Journal of Internal Medicine |
|---|---|
| Personen und Körperschaften: | |
| In: | Journal of Internal Medicine, 253, 2003, 4, S. 402-410 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Liu, M. A. Liu, M. A. |
|---|---|
| author |
Liu, M. A. |
| spellingShingle |
Liu, M. A. Journal of Internal Medicine DNA vaccines: a review Internal Medicine |
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liu, m. a. |
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Liu, M. A. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1046/j.1365-2796.2003.01140.x <jats:p> <jats:bold>Abstract.</jats:bold> Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a review (Review). <jats:italic>J Intern Med</jats:italic> 2003; <jats:bold>253:</jats:bold> 402–410.</jats:p><jats:p>The DNA vaccines are simple rings of DNA containing a gene encoding an antigen, and a promoter/terminator to make the gene express in mammalian cells. They are a promising new approach for generating all types of desired immunity: cytolytic T lymphocytes (CTL), T helper cells and antibodies, whilst being a technology that has the potential for global usage in terms of manufacturing ease, broad population administration and safety. This review gives an overview of the mechanisms, preclinical and clinical efficacy of DNA vaccines, and point out the limitations of the first generation of such vaccines, and some of the promising second‐generation developments. This technology is also being utilized in the field of proteomics as a tool to elucidate the function of genes. The breadth of applications for DNA vaccines thus ranges from prophylactic vaccines to immunotherapy for infectious diseases, cancer, and autoimmune and allergic diseases.</jats:p> DNA vaccines: a review Journal of Internal Medicine |
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Wiley, 2003 |
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| title |
DNA vaccines: a review |
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DNA vaccines: a review |
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DNA vaccines: a review |
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DNA vaccines: a review |
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DNA vaccines: a review |
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DNA vaccines: a review |
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dna vaccines: a review |
| topic |
Internal Medicine |
| url |
http://dx.doi.org/10.1046/j.1365-2796.2003.01140.x |
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2003 |
| physical |
402-410 |
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<jats:p> <jats:bold>Abstract.</jats:bold> Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a review (Review). <jats:italic>J Intern Med</jats:italic> 2003; <jats:bold>253:</jats:bold> 402–410.</jats:p><jats:p>The DNA vaccines are simple rings of DNA containing a gene encoding an antigen, and a promoter/terminator to make the gene express in mammalian cells. They are a promising new approach for generating all types of desired immunity: cytolytic T lymphocytes (CTL), T helper cells and antibodies, whilst being a technology that has the potential for global usage in terms of manufacturing ease, broad population administration and safety. This review gives an overview of the mechanisms, preclinical and clinical efficacy of DNA vaccines, and point out the limitations of the first generation of such vaccines, and some of the promising second‐generation developments. This technology is also being utilized in the field of proteomics as a tool to elucidate the function of genes. The breadth of applications for DNA vaccines thus ranges from prophylactic vaccines to immunotherapy for infectious diseases, cancer, and autoimmune and allergic diseases.</jats:p> |
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| description | <jats:p> <jats:bold>Abstract.</jats:bold> Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a review (Review). <jats:italic>J Intern Med</jats:italic> 2003; <jats:bold>253:</jats:bold> 402–410.</jats:p><jats:p>The DNA vaccines are simple rings of DNA containing a gene encoding an antigen, and a promoter/terminator to make the gene express in mammalian cells. They are a promising new approach for generating all types of desired immunity: cytolytic T lymphocytes (CTL), T helper cells and antibodies, whilst being a technology that has the potential for global usage in terms of manufacturing ease, broad population administration and safety. This review gives an overview of the mechanisms, preclinical and clinical efficacy of DNA vaccines, and point out the limitations of the first generation of such vaccines, and some of the promising second‐generation developments. This technology is also being utilized in the field of proteomics as a tool to elucidate the function of genes. The breadth of applications for DNA vaccines thus ranges from prophylactic vaccines to immunotherapy for infectious diseases, cancer, and autoimmune and allergic diseases.</jats:p> |
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| spelling | Liu, M. A. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1046/j.1365-2796.2003.01140.x <jats:p> <jats:bold>Abstract.</jats:bold> Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a review (Review). <jats:italic>J Intern Med</jats:italic> 2003; <jats:bold>253:</jats:bold> 402–410.</jats:p><jats:p>The DNA vaccines are simple rings of DNA containing a gene encoding an antigen, and a promoter/terminator to make the gene express in mammalian cells. They are a promising new approach for generating all types of desired immunity: cytolytic T lymphocytes (CTL), T helper cells and antibodies, whilst being a technology that has the potential for global usage in terms of manufacturing ease, broad population administration and safety. This review gives an overview of the mechanisms, preclinical and clinical efficacy of DNA vaccines, and point out the limitations of the first generation of such vaccines, and some of the promising second‐generation developments. This technology is also being utilized in the field of proteomics as a tool to elucidate the function of genes. The breadth of applications for DNA vaccines thus ranges from prophylactic vaccines to immunotherapy for infectious diseases, cancer, and autoimmune and allergic diseases.</jats:p> DNA vaccines: a review Journal of Internal Medicine |
| spellingShingle | Liu, M. A., Journal of Internal Medicine, DNA vaccines: a review, Internal Medicine |
| title | DNA vaccines: a review |
| title_full | DNA vaccines: a review |
| title_fullStr | DNA vaccines: a review |
| title_full_unstemmed | DNA vaccines: a review |
| title_short | DNA vaccines: a review |
| title_sort | dna vaccines: a review |
| title_unstemmed | DNA vaccines: a review |
| topic | Internal Medicine |
| url | http://dx.doi.org/10.1046/j.1365-2796.2003.01140.x |