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Clinical implications of telomerase detection
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| Zeitschriftentitel: | Histopathology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Histopathology, 38, 2001, 6, S. 485-498 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
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Matthews, P Jones, C J Matthews, P Jones, C J |
|---|---|
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Matthews, P Jones, C J |
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Matthews, P Jones, C J Histopathology Clinical implications of telomerase detection General Medicine Histology Pathology and Forensic Medicine |
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matthews, p |
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Matthews, P Jones, C J 0309-0167 1365-2559 Wiley General Medicine Histology Pathology and Forensic Medicine http://dx.doi.org/10.1046/j.1365-2559.2001.01186.x <jats:p> <jats:bold>Clinical implications of telomerase detection</jats:bold> </jats:p><jats:p>In 1994 a sensitive method for the detection of telomerase was described. This assay, which was based on the polymerase chain reaction, suggested that telomerase activity was associated with immortal and cancer cells. Since then more than a thousand studies have documented the expression and activity of the enzyme in diseased tissues, primarily tumours. This review gives an overview of the biological significance of telomerase expression and methods for detecting its activity. This is followed by an organ system‐based discussion of expression in normal tissues and disease states. We finish with speculation as to the future role of telomerase detection in diagnostic histopathology.</jats:p> Clinical implications of telomerase detection Histopathology |
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Clinical implications of telomerase detection |
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Clinical implications of telomerase detection |
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Clinical implications of telomerase detection |
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Clinical implications of telomerase detection |
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clinical implications of telomerase detection |
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General Medicine Histology Pathology and Forensic Medicine |
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<jats:p> <jats:bold>Clinical implications of telomerase detection</jats:bold> </jats:p><jats:p>In 1994 a sensitive method for the detection of telomerase was described. This assay, which was based on the polymerase chain reaction, suggested that telomerase activity was associated with immortal and cancer cells. Since then more than a thousand studies have documented the expression and activity of the enzyme in diseased tissues, primarily tumours. This review gives an overview of the biological significance of telomerase expression and methods for detecting its activity. This is followed by an organ system‐based discussion of expression in normal tissues and disease states. We finish with speculation as to the future role of telomerase detection in diagnostic histopathology.</jats:p> |
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| description | <jats:p> <jats:bold>Clinical implications of telomerase detection</jats:bold> </jats:p><jats:p>In 1994 a sensitive method for the detection of telomerase was described. This assay, which was based on the polymerase chain reaction, suggested that telomerase activity was associated with immortal and cancer cells. Since then more than a thousand studies have documented the expression and activity of the enzyme in diseased tissues, primarily tumours. This review gives an overview of the biological significance of telomerase expression and methods for detecting its activity. This is followed by an organ system‐based discussion of expression in normal tissues and disease states. We finish with speculation as to the future role of telomerase detection in diagnostic histopathology.</jats:p> |
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| spelling | Matthews, P Jones, C J 0309-0167 1365-2559 Wiley General Medicine Histology Pathology and Forensic Medicine http://dx.doi.org/10.1046/j.1365-2559.2001.01186.x <jats:p> <jats:bold>Clinical implications of telomerase detection</jats:bold> </jats:p><jats:p>In 1994 a sensitive method for the detection of telomerase was described. This assay, which was based on the polymerase chain reaction, suggested that telomerase activity was associated with immortal and cancer cells. Since then more than a thousand studies have documented the expression and activity of the enzyme in diseased tissues, primarily tumours. This review gives an overview of the biological significance of telomerase expression and methods for detecting its activity. This is followed by an organ system‐based discussion of expression in normal tissues and disease states. We finish with speculation as to the future role of telomerase detection in diagnostic histopathology.</jats:p> Clinical implications of telomerase detection Histopathology |
| spellingShingle | Matthews, P, Jones, C J, Histopathology, Clinical implications of telomerase detection, General Medicine, Histology, Pathology and Forensic Medicine |
| title | Clinical implications of telomerase detection |
| title_full | Clinical implications of telomerase detection |
| title_fullStr | Clinical implications of telomerase detection |
| title_full_unstemmed | Clinical implications of telomerase detection |
| title_short | Clinical implications of telomerase detection |
| title_sort | clinical implications of telomerase detection |
| title_unstemmed | Clinical implications of telomerase detection |
| topic | General Medicine, Histology, Pathology and Forensic Medicine |
| url | http://dx.doi.org/10.1046/j.1365-2559.2001.01186.x |