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Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin
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| Zeitschriftentitel: | European Journal of Clinical Investigation |
|---|---|
| Personen und Körperschaften: | , , |
| In: | European Journal of Clinical Investigation, 31, 2001, 11, S. 931-938 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Martin, T. A. Harding, K. Jiang, W. G. Martin, T. A. Harding, K. Jiang, W. G. |
|---|---|
| author |
Martin, T. A. Harding, K. Jiang, W. G. |
| spellingShingle |
Martin, T. A. Harding, K. Jiang, W. G. European Journal of Clinical Investigation Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin Clinical Biochemistry Biochemistry General Medicine |
| author_sort |
martin, t. a. |
| spelling |
Martin, T. A. Harding, K. Jiang, W. G. 0014-2972 1365-2362 Wiley Clinical Biochemistry Biochemistry General Medicine http://dx.doi.org/10.1046/j.1365-2362.2001.00914.x <jats:p><jats:bold>Background</jats:bold> Vascular endothelial cadherin (VE‐cadherin/cadherin‐5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix‐bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule‐formation by human endothelial cells, an indicator of angiogenic potential.</jats:p><jats:p><jats:bold>Results</jats:bold> Tubule formation stimulated by fibroblast‐derived growth factors can be prevented by the addition of monoclonal antibody to VE‐cadherin. In addition, fibroblasts‐derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin.</jats:p><jats:p><jats:bold>Conclusions</jats:bold> The change in VE‐cadherin expression of human endothelial cells by fibroblast‐derived growth factors may contribute to the regulation of angiogenesis.</jats:p> Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin European Journal of Clinical Investigation |
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Wiley, 2001 |
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Wiley, 2001 |
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2001 |
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Wiley |
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European Journal of Clinical Investigation |
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| title |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_unstemmed |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_full |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_fullStr |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_full_unstemmed |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_short |
Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_sort |
matrix‐bound fibroblasts regulate angiogenesis by modulation of ve‐cadherin |
| topic |
Clinical Biochemistry Biochemistry General Medicine |
| url |
http://dx.doi.org/10.1046/j.1365-2362.2001.00914.x |
| publishDate |
2001 |
| physical |
931-938 |
| description |
<jats:p><jats:bold>Background</jats:bold> Vascular endothelial cadherin (VE‐cadherin/cadherin‐5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix‐bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule‐formation by human endothelial cells, an indicator of angiogenic potential.</jats:p><jats:p><jats:bold>Results</jats:bold> Tubule formation stimulated by fibroblast‐derived growth factors can be prevented by the addition of monoclonal antibody to VE‐cadherin. In addition, fibroblasts‐derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin.</jats:p><jats:p><jats:bold>Conclusions</jats:bold> The change in VE‐cadherin expression of human endothelial cells by fibroblast‐derived growth factors may contribute to the regulation of angiogenesis.</jats:p> |
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| author | Martin, T. A., Harding, K., Jiang, W. G. |
| author_facet | Martin, T. A., Harding, K., Jiang, W. G., Martin, T. A., Harding, K., Jiang, W. G. |
| author_sort | martin, t. a. |
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| container_start_page | 931 |
| container_title | European Journal of Clinical Investigation |
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| description | <jats:p><jats:bold>Background</jats:bold> Vascular endothelial cadherin (VE‐cadherin/cadherin‐5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix‐bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule‐formation by human endothelial cells, an indicator of angiogenic potential.</jats:p><jats:p><jats:bold>Results</jats:bold> Tubule formation stimulated by fibroblast‐derived growth factors can be prevented by the addition of monoclonal antibody to VE‐cadherin. In addition, fibroblasts‐derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin.</jats:p><jats:p><jats:bold>Conclusions</jats:bold> The change in VE‐cadherin expression of human endothelial cells by fibroblast‐derived growth factors may contribute to the regulation of angiogenesis.</jats:p> |
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| imprint | Wiley, 2001 |
| imprint_str_mv | Wiley, 2001 |
| institution | DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| series | European Journal of Clinical Investigation |
| source_id | 49 |
| spelling | Martin, T. A. Harding, K. Jiang, W. G. 0014-2972 1365-2362 Wiley Clinical Biochemistry Biochemistry General Medicine http://dx.doi.org/10.1046/j.1365-2362.2001.00914.x <jats:p><jats:bold>Background</jats:bold> Vascular endothelial cadherin (VE‐cadherin/cadherin‐5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix‐bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule‐formation by human endothelial cells, an indicator of angiogenic potential.</jats:p><jats:p><jats:bold>Results</jats:bold> Tubule formation stimulated by fibroblast‐derived growth factors can be prevented by the addition of monoclonal antibody to VE‐cadherin. In addition, fibroblasts‐derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin.</jats:p><jats:p><jats:bold>Conclusions</jats:bold> The change in VE‐cadherin expression of human endothelial cells by fibroblast‐derived growth factors may contribute to the regulation of angiogenesis.</jats:p> Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin European Journal of Clinical Investigation |
| spellingShingle | Martin, T. A., Harding, K., Jiang, W. G., European Journal of Clinical Investigation, Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin, Clinical Biochemistry, Biochemistry, General Medicine |
| title | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_full | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_fullStr | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_full_unstemmed | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_short | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| title_sort | matrix‐bound fibroblasts regulate angiogenesis by modulation of ve‐cadherin |
| title_unstemmed | Matrix‐bound fibroblasts regulate angiogenesis by modulation of VE‐cadherin |
| topic | Clinical Biochemistry, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1046/j.1365-2362.2001.00914.x |