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Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome
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| Zeitschriftentitel: | British Journal of Clinical Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | British Journal of Clinical Pharmacology, 56, 2003, 2, S. 228-231 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn |
|---|---|
| author |
Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn |
| spellingShingle |
Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn British Journal of Clinical Pharmacology Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome Pharmacology (medical) Pharmacology |
| author_sort |
skarke, carsten |
| spelling |
Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1046/j.1365-2125.2003.01866.x <jats:p><jats:bold>Aims </jats:bold> To verify that Gilbert's syndrome, which is caused by decreased glucuronidation capacity of the UDP‐glucuronosyl transferase (UGT)1A1, does not account for impaired morphine clearance.</jats:p><jats:p><jats:bold>Methods </jats:bold> Noncompartmental pharmacokinetic parameters for morphine and its glucuronide metabolites were compared between five carriers of Gilbert's syndrome and six noncarriers after a 7.5 mg (19.8 µmol) intravenous injection of morphine sulphate pentahydrate. To estimate the amount of morphine‐6‐glucuronide (M6G) formed from morphine, 1 mg of deuterized M6G was injected intravenously at the same time.</jats:p><jats:p><jats:bold>Results </jats:bold> No differences were detected between carriers and noncarriers of Gilbert's syndrome in the clearance of morphine (80.1 ± 12 l h<jats:sup>−1</jats:sup><jats:italic>vs</jats:italic> 87.9 ± 22 l h<jats:sup>−1</jats:sup>) and in the percentage of morphine that was metabolized to M6G (10.9 ± 1.4 <jats:italic>vs</jats:italic> 13 ± 2). The areas under the plasma concentration <jats:italic>vs</jats:italic> time curves of morphine, M6G and morphine‐3‐glucuronide also did not differ between carriers and noncarriers of Gilbert's syndrome.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> Gilbert's syndrome is not a factor to be considered when prescribing morphine.</jats:p> Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome British Journal of Clinical Pharmacology |
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10.1046/j.1365-2125.2003.01866.x |
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Online Free |
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Wiley, 2003 |
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Wiley, 2003 |
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0306-5251 1365-2125 |
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2003 |
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Wiley |
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British Journal of Clinical Pharmacology |
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49 |
| title |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_unstemmed |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_full |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_fullStr |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_full_unstemmed |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_short |
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_sort |
pharmacokinetics of morphine are not altered in subjects with gilbert's syndrome |
| topic |
Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1046/j.1365-2125.2003.01866.x |
| publishDate |
2003 |
| physical |
228-231 |
| description |
<jats:p><jats:bold>Aims </jats:bold> To verify that Gilbert's syndrome, which is caused by decreased glucuronidation capacity of the UDP‐glucuronosyl transferase (UGT)1A1, does not account for impaired morphine clearance.</jats:p><jats:p><jats:bold>Methods </jats:bold> Noncompartmental pharmacokinetic parameters for morphine and its glucuronide metabolites were compared between five carriers of Gilbert's syndrome and six noncarriers after a 7.5 mg (19.8 µmol) intravenous injection of morphine sulphate pentahydrate. To estimate the amount of morphine‐6‐glucuronide (M6G) formed from morphine, 1 mg of deuterized M6G was injected intravenously at the same time.</jats:p><jats:p><jats:bold>Results </jats:bold> No differences were detected between carriers and noncarriers of Gilbert's syndrome in the clearance of morphine (80.1 ± 12 l h<jats:sup>−1</jats:sup><jats:italic>vs</jats:italic> 87.9 ± 22 l h<jats:sup>−1</jats:sup>) and in the percentage of morphine that was metabolized to M6G (10.9 ± 1.4 <jats:italic>vs</jats:italic> 13 ± 2). The areas under the plasma concentration <jats:italic>vs</jats:italic> time curves of morphine, M6G and morphine‐3‐glucuronide also did not differ between carriers and noncarriers of Gilbert's syndrome.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> Gilbert's syndrome is not a factor to be considered when prescribing morphine.</jats:p> |
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| _version_ | 1792337331541245960 |
| author | Skarke, Carsten, Schmidt, Helmut, Geisslinger, Gerd, Darimont, Jutta, Lötsch, Jörn |
| author_facet | Skarke, Carsten, Schmidt, Helmut, Geisslinger, Gerd, Darimont, Jutta, Lötsch, Jörn, Skarke, Carsten, Schmidt, Helmut, Geisslinger, Gerd, Darimont, Jutta, Lötsch, Jörn |
| author_sort | skarke, carsten |
| container_issue | 2 |
| container_start_page | 228 |
| container_title | British Journal of Clinical Pharmacology |
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| description | <jats:p><jats:bold>Aims </jats:bold> To verify that Gilbert's syndrome, which is caused by decreased glucuronidation capacity of the UDP‐glucuronosyl transferase (UGT)1A1, does not account for impaired morphine clearance.</jats:p><jats:p><jats:bold>Methods </jats:bold> Noncompartmental pharmacokinetic parameters for morphine and its glucuronide metabolites were compared between five carriers of Gilbert's syndrome and six noncarriers after a 7.5 mg (19.8 µmol) intravenous injection of morphine sulphate pentahydrate. To estimate the amount of morphine‐6‐glucuronide (M6G) formed from morphine, 1 mg of deuterized M6G was injected intravenously at the same time.</jats:p><jats:p><jats:bold>Results </jats:bold> No differences were detected between carriers and noncarriers of Gilbert's syndrome in the clearance of morphine (80.1 ± 12 l h<jats:sup>−1</jats:sup><jats:italic>vs</jats:italic> 87.9 ± 22 l h<jats:sup>−1</jats:sup>) and in the percentage of morphine that was metabolized to M6G (10.9 ± 1.4 <jats:italic>vs</jats:italic> 13 ± 2). The areas under the plasma concentration <jats:italic>vs</jats:italic> time curves of morphine, M6G and morphine‐3‐glucuronide also did not differ between carriers and noncarriers of Gilbert's syndrome.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> Gilbert's syndrome is not a factor to be considered when prescribing morphine.</jats:p> |
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| imprint | Wiley, 2003 |
| imprint_str_mv | Wiley, 2003 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
| issn | 0306-5251, 1365-2125 |
| issn_str_mv | 0306-5251, 1365-2125 |
| language | English |
| last_indexed | 2024-03-01T15:14:39.422Z |
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| physical | 228-231 |
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| source_id | 49 |
| spelling | Skarke, Carsten Schmidt, Helmut Geisslinger, Gerd Darimont, Jutta Lötsch, Jörn 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1046/j.1365-2125.2003.01866.x <jats:p><jats:bold>Aims </jats:bold> To verify that Gilbert's syndrome, which is caused by decreased glucuronidation capacity of the UDP‐glucuronosyl transferase (UGT)1A1, does not account for impaired morphine clearance.</jats:p><jats:p><jats:bold>Methods </jats:bold> Noncompartmental pharmacokinetic parameters for morphine and its glucuronide metabolites were compared between five carriers of Gilbert's syndrome and six noncarriers after a 7.5 mg (19.8 µmol) intravenous injection of morphine sulphate pentahydrate. To estimate the amount of morphine‐6‐glucuronide (M6G) formed from morphine, 1 mg of deuterized M6G was injected intravenously at the same time.</jats:p><jats:p><jats:bold>Results </jats:bold> No differences were detected between carriers and noncarriers of Gilbert's syndrome in the clearance of morphine (80.1 ± 12 l h<jats:sup>−1</jats:sup><jats:italic>vs</jats:italic> 87.9 ± 22 l h<jats:sup>−1</jats:sup>) and in the percentage of morphine that was metabolized to M6G (10.9 ± 1.4 <jats:italic>vs</jats:italic> 13 ± 2). The areas under the plasma concentration <jats:italic>vs</jats:italic> time curves of morphine, M6G and morphine‐3‐glucuronide also did not differ between carriers and noncarriers of Gilbert's syndrome.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> Gilbert's syndrome is not a factor to be considered when prescribing morphine.</jats:p> Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome British Journal of Clinical Pharmacology |
| spellingShingle | Skarke, Carsten, Schmidt, Helmut, Geisslinger, Gerd, Darimont, Jutta, Lötsch, Jörn, British Journal of Clinical Pharmacology, Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome, Pharmacology (medical), Pharmacology |
| title | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_full | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_fullStr | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_full_unstemmed | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_short | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| title_sort | pharmacokinetics of morphine are not altered in subjects with gilbert's syndrome |
| title_unstemmed | Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome |
| topic | Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1046/j.1365-2125.2003.01866.x |