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Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients*
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| Zeitschriftentitel: | British Journal of Haematology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | British Journal of Haematology, 118, 2002, 3, S. 893-898 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee |
|---|---|
| author |
Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee |
| spellingShingle |
Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee British Journal of Haematology Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* Hematology |
| author_sort |
atichartakarn, vichai |
| spelling |
Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1046/j.1365-2141.2002.03711.x <jats:p><jats:bold>Summary.</jats:bold> Small pulmonary arterial thromboses can occur following splenectomy of patients with haemoglobin E/β‐thalassaemia (Hb E/β‐thal). We compared plasma markers of coagulation activation <jats:italic>in vivo</jats:italic> and red blood cell (RBC) markers of procoagulant activity in 15 Hb E/β‐thal patients who were not splenectomized (NS), 15 who had been splenectomized (S), and 15 normal controls (NC). Levels of plasma thrombin–antithrombin III complex (TAT) were significantly higher in the S group than in either the NS or the NC groups, and levels of prothrombin fragment 1.2 (F 1.2) were significantly higher in the S than in the NC group. Diluted Russell's viper venom clotting times were significantly shorter when RBCs from group S patients were added to the assay compared with RBCs from the NC group. Phosphatidylserine (PS) expression (% of annexin V‐positive RBCs) on the outer leaflet of RBC membrane of both ‘larger’‐ and ‘smaller’‐sized RBCs was significantly higher for the S than the NC group. The RBC PS expression of the S and the NS groups, respectively, accounted for 25·3% (<jats:italic>P</jats:italic> = 0·174) and 6·3% (<jats:italic>P</jats:italic> = 0·675) of the variation in plasma TAT levels. Our findings indicated that, when compared with NC, splenectomized patients with Hb E/β‐thal were in a chronic low‐grade hypercoagulable state associated with increased numbers of circulating PS exposed RBCs. This condition may have a role in the risk of these patients for pulmonary arterial thromboses.</jats:p> Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* British Journal of Haematology |
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| title |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_unstemmed |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_full |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_fullStr |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_full_unstemmed |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_short |
Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_sort |
relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin e/β‐thalassaemic patients* |
| topic |
Hematology |
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http://dx.doi.org/10.1046/j.1365-2141.2002.03711.x |
| publishDate |
2002 |
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893-898 |
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<jats:p><jats:bold>Summary.</jats:bold> Small pulmonary arterial thromboses can occur following splenectomy of patients with haemoglobin E/β‐thalassaemia (Hb E/β‐thal). We compared plasma markers of coagulation activation <jats:italic>in vivo</jats:italic> and red blood cell (RBC) markers of procoagulant activity in 15 Hb E/β‐thal patients who were not splenectomized (NS), 15 who had been splenectomized (S), and 15 normal controls (NC). Levels of plasma thrombin–antithrombin III complex (TAT) were significantly higher in the S group than in either the NS or the NC groups, and levels of prothrombin fragment 1.2 (F 1.2) were significantly higher in the S than in the NC group. Diluted Russell's viper venom clotting times were significantly shorter when RBCs from group S patients were added to the assay compared with RBCs from the NC group. Phosphatidylserine (PS) expression (% of annexin V‐positive RBCs) on the outer leaflet of RBC membrane of both ‘larger’‐ and ‘smaller’‐sized RBCs was significantly higher for the S than the NC group. The RBC PS expression of the S and the NS groups, respectively, accounted for 25·3% (<jats:italic>P</jats:italic> = 0·174) and 6·3% (<jats:italic>P</jats:italic> = 0·675) of the variation in plasma TAT levels. Our findings indicated that, when compared with NC, splenectomized patients with Hb E/β‐thal were in a chronic low‐grade hypercoagulable state associated with increased numbers of circulating PS exposed RBCs. This condition may have a role in the risk of these patients for pulmonary arterial thromboses.</jats:p> |
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| author | Atichartakarn, Vichai, Angchaisuksiri, Pantep, Aryurachai, Katcharin, Onpun, Supornchai, Chuncharunee, Suporn, Thakkinstian, Ammarin, Atamasirikul, Kanlayanee |
| author_facet | Atichartakarn, Vichai, Angchaisuksiri, Pantep, Aryurachai, Katcharin, Onpun, Supornchai, Chuncharunee, Suporn, Thakkinstian, Ammarin, Atamasirikul, Kanlayanee, Atichartakarn, Vichai, Angchaisuksiri, Pantep, Aryurachai, Katcharin, Onpun, Supornchai, Chuncharunee, Suporn, Thakkinstian, Ammarin, Atamasirikul, Kanlayanee |
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| description | <jats:p><jats:bold>Summary.</jats:bold> Small pulmonary arterial thromboses can occur following splenectomy of patients with haemoglobin E/β‐thalassaemia (Hb E/β‐thal). We compared plasma markers of coagulation activation <jats:italic>in vivo</jats:italic> and red blood cell (RBC) markers of procoagulant activity in 15 Hb E/β‐thal patients who were not splenectomized (NS), 15 who had been splenectomized (S), and 15 normal controls (NC). Levels of plasma thrombin–antithrombin III complex (TAT) were significantly higher in the S group than in either the NS or the NC groups, and levels of prothrombin fragment 1.2 (F 1.2) were significantly higher in the S than in the NC group. Diluted Russell's viper venom clotting times were significantly shorter when RBCs from group S patients were added to the assay compared with RBCs from the NC group. Phosphatidylserine (PS) expression (% of annexin V‐positive RBCs) on the outer leaflet of RBC membrane of both ‘larger’‐ and ‘smaller’‐sized RBCs was significantly higher for the S than the NC group. The RBC PS expression of the S and the NS groups, respectively, accounted for 25·3% (<jats:italic>P</jats:italic> = 0·174) and 6·3% (<jats:italic>P</jats:italic> = 0·675) of the variation in plasma TAT levels. Our findings indicated that, when compared with NC, splenectomized patients with Hb E/β‐thal were in a chronic low‐grade hypercoagulable state associated with increased numbers of circulating PS exposed RBCs. This condition may have a role in the risk of these patients for pulmonary arterial thromboses.</jats:p> |
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| spelling | Atichartakarn, Vichai Angchaisuksiri, Pantep Aryurachai, Katcharin Onpun, Supornchai Chuncharunee, Suporn Thakkinstian, Ammarin Atamasirikul, Kanlayanee 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1046/j.1365-2141.2002.03711.x <jats:p><jats:bold>Summary.</jats:bold> Small pulmonary arterial thromboses can occur following splenectomy of patients with haemoglobin E/β‐thalassaemia (Hb E/β‐thal). We compared plasma markers of coagulation activation <jats:italic>in vivo</jats:italic> and red blood cell (RBC) markers of procoagulant activity in 15 Hb E/β‐thal patients who were not splenectomized (NS), 15 who had been splenectomized (S), and 15 normal controls (NC). Levels of plasma thrombin–antithrombin III complex (TAT) were significantly higher in the S group than in either the NS or the NC groups, and levels of prothrombin fragment 1.2 (F 1.2) were significantly higher in the S than in the NC group. Diluted Russell's viper venom clotting times were significantly shorter when RBCs from group S patients were added to the assay compared with RBCs from the NC group. Phosphatidylserine (PS) expression (% of annexin V‐positive RBCs) on the outer leaflet of RBC membrane of both ‘larger’‐ and ‘smaller’‐sized RBCs was significantly higher for the S than the NC group. The RBC PS expression of the S and the NS groups, respectively, accounted for 25·3% (<jats:italic>P</jats:italic> = 0·174) and 6·3% (<jats:italic>P</jats:italic> = 0·675) of the variation in plasma TAT levels. Our findings indicated that, when compared with NC, splenectomized patients with Hb E/β‐thal were in a chronic low‐grade hypercoagulable state associated with increased numbers of circulating PS exposed RBCs. This condition may have a role in the risk of these patients for pulmonary arterial thromboses.</jats:p> Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* British Journal of Haematology |
| spellingShingle | Atichartakarn, Vichai, Angchaisuksiri, Pantep, Aryurachai, Katcharin, Onpun, Supornchai, Chuncharunee, Suporn, Thakkinstian, Ammarin, Atamasirikul, Kanlayanee, British Journal of Haematology, Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients*, Hematology |
| title | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_full | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_fullStr | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_full_unstemmed | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_short | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| title_sort | relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin e/β‐thalassaemic patients* |
| title_unstemmed | Relationship between hypercoagulable state and erythrocyte phosphatidylserine exposure in splenectomized haemoglobin E/β‐thalassaemic patients* |
| topic | Hematology |
| url | http://dx.doi.org/10.1046/j.1365-2141.2002.03711.x |