author_facet Rohaizak, Muhammad
Farndon, John Richard
Rohaizak, Muhammad
Farndon, John Richard
author Rohaizak, Muhammad
Farndon, John Richard
spellingShingle Rohaizak, Muhammad
Farndon, John Richard
ANZ Journal of Surgery
Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
General Medicine
Surgery
author_sort rohaizak, muhammad
spelling Rohaizak, Muhammad Farndon, John Richard 1445-1433 1445-2197 Wiley General Medicine Surgery http://dx.doi.org/10.1046/j.1445-2197.2002.02507.x <jats:p> <jats:bold>Background:</jats:bold> Carcinoid tumours are rare neoplasms that secrete hormones and biogenic amines, most commonly serotonin. Octreotide and long acting lanreotide are found to be useful in the management of carcinoid syndrome by its interaction with somatostatin receptor, found on the carcinoid tumour. The aim of this study is to look at the efficacy of octreotide and long acting lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Method:</jats:bold> The effects of octreotide and long‐acting lanreotide were studied in 10 patients with symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Results:</jats:bold> Symptom improvement occurred in nine of 10 patients. Three patients responded only to octreotide, three patients responded to both octreotide and long‐acting lanreotide and three patients only responded to long‐acting lanreotide. Slight reductions in 24‐h urine 5‐hydroxyindoleacetic acid levels occurred in three of six patients but no patients were found to have objective tumour regression on computed tomography scan.</jats:p><jats:p> <jats:bold>Conclusions:</jats:bold> Octreotide and long‐acting lanreotide are useful palliative treatments for the control of symptoms in patients with non‐resectable carcinoid tumours but there is no evidence of tumour stasis.</jats:p> Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours ANZ Journal of Surgery
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title Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_unstemmed Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_full Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_fullStr Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_full_unstemmed Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_short Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_sort use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
topic General Medicine
Surgery
url http://dx.doi.org/10.1046/j.1445-2197.2002.02507.x
publishDate 2002
physical 635-638
description <jats:p> <jats:bold>Background:</jats:bold>  Carcinoid tumours are rare neoplasms that secrete hormones and biogenic amines, most commonly serotonin. Octreotide and long acting lanreotide are found to be useful in the management of carcinoid syndrome by its interaction with somatostatin receptor, found on the carcinoid tumour. The aim of this study is to look at the efficacy of octreotide and long acting lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Method:</jats:bold>  The effects of octreotide and long‐acting lanreotide were studied in 10 patients with symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Results:</jats:bold>  Symptom improvement occurred in nine of 10 patients. Three patients responded only to octreotide, three patients responded to both octreotide and long‐acting lanreotide and three patients only responded to long‐acting lanreotide. Slight reductions in 24‐h urine 5‐hydroxyindoleacetic acid levels occurred in three of six patients but no patients were found to have objective tumour regression on computed tomography scan.</jats:p><jats:p> <jats:bold>Conclusions:</jats:bold>  Octreotide and long‐acting lanreotide are useful palliative treatments for the control of symptoms in patients with non‐resectable carcinoid tumours but there is no evidence of tumour stasis.</jats:p>
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author Rohaizak, Muhammad, Farndon, John Richard
author_facet Rohaizak, Muhammad, Farndon, John Richard, Rohaizak, Muhammad, Farndon, John Richard
author_sort rohaizak, muhammad
container_issue 9
container_start_page 635
container_title ANZ Journal of Surgery
container_volume 72
description <jats:p> <jats:bold>Background:</jats:bold>  Carcinoid tumours are rare neoplasms that secrete hormones and biogenic amines, most commonly serotonin. Octreotide and long acting lanreotide are found to be useful in the management of carcinoid syndrome by its interaction with somatostatin receptor, found on the carcinoid tumour. The aim of this study is to look at the efficacy of octreotide and long acting lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Method:</jats:bold>  The effects of octreotide and long‐acting lanreotide were studied in 10 patients with symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Results:</jats:bold>  Symptom improvement occurred in nine of 10 patients. Three patients responded only to octreotide, three patients responded to both octreotide and long‐acting lanreotide and three patients only responded to long‐acting lanreotide. Slight reductions in 24‐h urine 5‐hydroxyindoleacetic acid levels occurred in three of six patients but no patients were found to have objective tumour regression on computed tomography scan.</jats:p><jats:p> <jats:bold>Conclusions:</jats:bold>  Octreotide and long‐acting lanreotide are useful palliative treatments for the control of symptoms in patients with non‐resectable carcinoid tumours but there is no evidence of tumour stasis.</jats:p>
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spelling Rohaizak, Muhammad Farndon, John Richard 1445-1433 1445-2197 Wiley General Medicine Surgery http://dx.doi.org/10.1046/j.1445-2197.2002.02507.x <jats:p> <jats:bold>Background:</jats:bold> Carcinoid tumours are rare neoplasms that secrete hormones and biogenic amines, most commonly serotonin. Octreotide and long acting lanreotide are found to be useful in the management of carcinoid syndrome by its interaction with somatostatin receptor, found on the carcinoid tumour. The aim of this study is to look at the efficacy of octreotide and long acting lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Method:</jats:bold> The effects of octreotide and long‐acting lanreotide were studied in 10 patients with symptomatic non‐resectable carcinoid tumours.</jats:p><jats:p> <jats:bold>Results:</jats:bold> Symptom improvement occurred in nine of 10 patients. Three patients responded only to octreotide, three patients responded to both octreotide and long‐acting lanreotide and three patients only responded to long‐acting lanreotide. Slight reductions in 24‐h urine 5‐hydroxyindoleacetic acid levels occurred in three of six patients but no patients were found to have objective tumour regression on computed tomography scan.</jats:p><jats:p> <jats:bold>Conclusions:</jats:bold> Octreotide and long‐acting lanreotide are useful palliative treatments for the control of symptoms in patients with non‐resectable carcinoid tumours but there is no evidence of tumour stasis.</jats:p> Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours ANZ Journal of Surgery
spellingShingle Rohaizak, Muhammad, Farndon, John Richard, ANZ Journal of Surgery, Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours, General Medicine, Surgery
title Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_full Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_fullStr Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_full_unstemmed Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_short Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_sort use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
title_unstemmed Use of octreotide and lanreotide in the treatment of symptomatic non‐resectable carcinoid tumours
topic General Medicine, Surgery
url http://dx.doi.org/10.1046/j.1445-2197.2002.02507.x