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Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Bioscience Reports, 39, 2019, 3 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
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| Schlagwörter: |
| author_facet |
Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan |
|---|---|
| author |
Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan |
| spellingShingle |
Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan Bioscience Reports Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
huang, yan |
| spelling |
Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20190003 <jats:title>Abstract</jats:title> <jats:p>Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for locally advanced rectal cancer. Here, we analyzed the impact of local and systemic environments on the tumor response to preoperative chemoradiotherapy in rectal cancer. We recruited 141 patients with rectal cancer treated with nCRT. We evaluated the local tumor environment, including tumor-infiltrating lymphocytes (TILs), intratumor budding (ITB), and the systemic inflammatory environment, including the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) level. Our finding revealed that tumor regression was significantly associated with the density of CD8+ TILs in the intraepithelial, the presence of ITB, the combination of NLR and CRP (NLR-CRP) value, and the combination of CD8+ intraepithelial TIL (iTIL) density and ITB presence. Moreover, multivariate analysis showed that only the combination of CD8+ iTILs and ITB was an independent predictive factor for the pathological response to nCRT in rectal cancer. Our finding demonstrate that the local tumor environment was a better predictor of the tumor response than the systemic environment and thus provided new insight into screening for patients who are more likely to benefit from cancer treatment.</jats:p> Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer Bioscience Reports |
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| title |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_unstemmed |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_full |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_fullStr |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_full_unstemmed |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_short |
Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_sort |
local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20190003 |
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2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for locally advanced rectal cancer. Here, we analyzed the impact of local and systemic environments on the tumor response to preoperative chemoradiotherapy in rectal cancer. We recruited 141 patients with rectal cancer treated with nCRT. We evaluated the local tumor environment, including tumor-infiltrating lymphocytes (TILs), intratumor budding (ITB), and the systemic inflammatory environment, including the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) level. Our finding revealed that tumor regression was significantly associated with the density of CD8+ TILs in the intraepithelial, the presence of ITB, the combination of NLR and CRP (NLR-CRP) value, and the combination of CD8+ intraepithelial TIL (iTIL) density and ITB presence. Moreover, multivariate analysis showed that only the combination of CD8+ iTILs and ITB was an independent predictive factor for the pathological response to nCRT in rectal cancer. Our finding demonstrate that the local tumor environment was a better predictor of the tumor response than the systemic environment and thus provided new insight into screening for patients who are more likely to benefit from cancer treatment.</jats:p> |
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| author | Huang, Yan, Lou, Xiao-ying, Zhu, Ya-xi, Wang, Yu-chen, Zhang, Lei, Liu, Hai-ling, Wang, Chao, Zhan, Huan-miao, Cheng, Zhi-qiang, Tan, Wei-yan, Wang, Lei, Fan, Xin-juan |
| author_facet | Huang, Yan, Lou, Xiao-ying, Zhu, Ya-xi, Wang, Yu-chen, Zhang, Lei, Liu, Hai-ling, Wang, Chao, Zhan, Huan-miao, Cheng, Zhi-qiang, Tan, Wei-yan, Wang, Lei, Fan, Xin-juan, Huang, Yan, Lou, Xiao-ying, Zhu, Ya-xi, Wang, Yu-chen, Zhang, Lei, Liu, Hai-ling, Wang, Chao, Zhan, Huan-miao, Cheng, Zhi-qiang, Tan, Wei-yan, Wang, Lei, Fan, Xin-juan |
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| description | <jats:title>Abstract</jats:title> <jats:p>Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for locally advanced rectal cancer. Here, we analyzed the impact of local and systemic environments on the tumor response to preoperative chemoradiotherapy in rectal cancer. We recruited 141 patients with rectal cancer treated with nCRT. We evaluated the local tumor environment, including tumor-infiltrating lymphocytes (TILs), intratumor budding (ITB), and the systemic inflammatory environment, including the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) level. Our finding revealed that tumor regression was significantly associated with the density of CD8+ TILs in the intraepithelial, the presence of ITB, the combination of NLR and CRP (NLR-CRP) value, and the combination of CD8+ intraepithelial TIL (iTIL) density and ITB presence. Moreover, multivariate analysis showed that only the combination of CD8+ iTILs and ITB was an independent predictive factor for the pathological response to nCRT in rectal cancer. Our finding demonstrate that the local tumor environment was a better predictor of the tumor response than the systemic environment and thus provided new insight into screening for patients who are more likely to benefit from cancer treatment.</jats:p> |
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| spelling | Huang, Yan Lou, Xiao-ying Zhu, Ya-xi Wang, Yu-chen Zhang, Lei Liu, Hai-ling Wang, Chao Zhan, Huan-miao Cheng, Zhi-qiang Tan, Wei-yan Wang, Lei Fan, Xin-juan 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20190003 <jats:title>Abstract</jats:title> <jats:p>Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for locally advanced rectal cancer. Here, we analyzed the impact of local and systemic environments on the tumor response to preoperative chemoradiotherapy in rectal cancer. We recruited 141 patients with rectal cancer treated with nCRT. We evaluated the local tumor environment, including tumor-infiltrating lymphocytes (TILs), intratumor budding (ITB), and the systemic inflammatory environment, including the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) level. Our finding revealed that tumor regression was significantly associated with the density of CD8+ TILs in the intraepithelial, the presence of ITB, the combination of NLR and CRP (NLR-CRP) value, and the combination of CD8+ intraepithelial TIL (iTIL) density and ITB presence. Moreover, multivariate analysis showed that only the combination of CD8+ iTILs and ITB was an independent predictive factor for the pathological response to nCRT in rectal cancer. Our finding demonstrate that the local tumor environment was a better predictor of the tumor response than the systemic environment and thus provided new insight into screening for patients who are more likely to benefit from cancer treatment.</jats:p> Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer Bioscience Reports |
| spellingShingle | Huang, Yan, Lou, Xiao-ying, Zhu, Ya-xi, Wang, Yu-chen, Zhang, Lei, Liu, Hai-ling, Wang, Chao, Zhan, Huan-miao, Cheng, Zhi-qiang, Tan, Wei-yan, Wang, Lei, Fan, Xin-juan, Bioscience Reports, Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_full | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_fullStr | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_full_unstemmed | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_short | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_sort | local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| title_unstemmed | Local environment in biopsy better predict the pathological response to neoadjuvant chemoradiotherapy in rectal cancer |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20190003 |