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OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Bioscience Reports, 39, 2019, 2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing |
|---|---|
| author |
Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing |
| spellingShingle |
Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing Bioscience Reports OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
shang, houlai |
| spelling |
Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20182023 <jats:title>Abstract</jats:title> <jats:p>Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case–control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) &lt; 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.</jats:p> <i>OPN</i> gene locus is associated with the risk of knee osteoarthritis: a case–control study Bioscience Reports |
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Portland Press Ltd., 2019 |
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| title |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_unstemmed |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_full |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_fullStr |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_full_unstemmed |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_short |
OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_sort |
<i>opn</i> gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
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http://dx.doi.org/10.1042/bsr20182023 |
| publishDate |
2019 |
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|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case–control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) &lt; 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.</jats:p> |
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| author | Shang, Houlai, Hao, Yuedong, Hu, Wenhao, Hu, Xiaohui, Jin, Qing |
| author_facet | Shang, Houlai, Hao, Yuedong, Hu, Wenhao, Hu, Xiaohui, Jin, Qing, Shang, Houlai, Hao, Yuedong, Hu, Wenhao, Hu, Xiaohui, Jin, Qing |
| author_sort | shang, houlai |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case–control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) &lt; 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.</jats:p> |
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| imprint_str_mv | Portland Press Ltd., 2019 |
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| series | Bioscience Reports |
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| spelling | Shang, Houlai Hao, Yuedong Hu, Wenhao Hu, Xiaohui Jin, Qing 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20182023 <jats:title>Abstract</jats:title> <jats:p>Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case–control study was to investigate the association between OPN gene rs11730582 polymorphism and knee OA risk in a Chinese population. Genotyping was analyzed using standard PCR and restriction fragment length polymorphism (PCR-RFLP). Results: The present study found that C allele or CC genotype of OPN gene rs11730582 polymorphism was related to decreased risk for knee OA. Furthermore, positive associations were obtained amongst the females, and body mass index (BMI) &lt; 25 kg/m2 groups. Conclusions: To sum up, the present study reveals that OPN gene rs11730582 polymorphism decreases the risk of knee OA in Chinese Han population.</jats:p> <i>OPN</i> gene locus is associated with the risk of knee osteoarthritis: a case–control study Bioscience Reports |
| spellingShingle | Shang, Houlai, Hao, Yuedong, Hu, Wenhao, Hu, Xiaohui, Jin, Qing, Bioscience Reports, OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_full | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_fullStr | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_full_unstemmed | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_short | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_sort | <i>opn</i> gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| title_unstemmed | OPN gene locus is associated with the risk of knee osteoarthritis: a case–control study |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20182023 |