Eintrag weiter verarbeiten
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer
Gespeichert in:
| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Bioscience Reports, 39, 2019, 3 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong |
|---|---|
| author |
Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong |
| spellingShingle |
Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong Bioscience Reports High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
liu, shuang |
| spelling |
Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181639 <jats:title>Abstract</jats:title> <jats:p>Tripartite motif containing 44 (TRIM44) has been reported to be up-regulated in multiple aggressive malignant tumors. However, its expression status and clinical significance in cervical cancer remain unknown. The purpose of this study was to investigate the clinical significance of TRIM44 expression and the prognosis in patients with cervical cancer (CC). Fresh frozen tissues from 5 samples of CC and 4 normal cervical tissues were analyzed for TRIM44 expression using RT- PCR and Western blot analysis. 122 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry. TRIM44 expression was found to be significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues (P&lt;0.001). Statistical analysis showed that TRIM44 expression was significantly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly expressing TRIM44 have significantly shorter overall survival (OS) (P=0.006) and disease-free survival (DFS) (P=0.002). Furthermore, multivariate Cox analysis showed TRIM44 was an independent risk factor for poor prognosis. Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer.</jats:p> High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer Bioscience Reports |
| doi_str_mv |
10.1042/bsr20181639 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Chemie und Pharmazie Physik |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTYzOQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTYzOQ |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Portland Press Ltd., 2019 |
| imprint_str_mv |
Portland Press Ltd., 2019 |
| issn |
0144-8463 1573-4935 |
| issn_str_mv |
0144-8463 1573-4935 |
| language |
English |
| mega_collection |
Portland Press Ltd. (CrossRef) |
| match_str |
liu2019hightrim44expressionasavaluablebiomarkerfordiagnosisandprognosisincervicalcancer |
| publishDateSort |
2019 |
| publisher |
Portland Press Ltd. |
| recordtype |
ai |
| record_format |
ai |
| series |
Bioscience Reports |
| source_id |
49 |
| title |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_unstemmed |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_full |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_fullStr |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_full_unstemmed |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_short |
High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_sort |
high trim44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20181639 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Tripartite motif containing 44 (TRIM44) has been reported to be up-regulated in multiple aggressive malignant tumors. However, its expression status and clinical significance in cervical cancer remain unknown. The purpose of this study was to investigate the clinical significance of TRIM44 expression and the prognosis in patients with cervical cancer (CC). Fresh frozen tissues from 5 samples of CC and 4 normal cervical tissues were analyzed for TRIM44 expression using RT- PCR and Western blot analysis. 122 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry. TRIM44 expression was found to be significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues (P&lt;0.001). Statistical analysis showed that TRIM44 expression was significantly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly expressing TRIM44 have significantly shorter overall survival (OS) (P=0.006) and disease-free survival (DFS) (P=0.002). Furthermore, multivariate Cox analysis showed TRIM44 was an independent risk factor for poor prognosis. Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer.</jats:p> |
| container_issue |
3 |
| container_start_page |
0 |
| container_title |
Bioscience Reports |
| container_volume |
39 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792335458225618951 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:44:52.883Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=High+TRIM44+expression+as+a+valuable+biomarker+for+diagnosis+and+prognosis+in+cervical+cancer&rft.date=2019-03-29&genre=article&issn=1573-4935&volume=39&issue=3&jtitle=Bioscience+Reports&atitle=High+TRIM44+expression+as+a+valuable+biomarker+for+diagnosis+and+prognosis+in+cervical+cancer&aulast=Ma&aufirst=Rong&rft_id=info%3Adoi%2F10.1042%2Fbsr20181639&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792335458225618951 |
| author | Liu, Shuang, Meng, Fanling, Ding, Jing, Ji, Hongying, Lin, Mu, Zhu, Jiaqi, Ma, Rong |
| author_facet | Liu, Shuang, Meng, Fanling, Ding, Jing, Ji, Hongying, Lin, Mu, Zhu, Jiaqi, Ma, Rong, Liu, Shuang, Meng, Fanling, Ding, Jing, Ji, Hongying, Lin, Mu, Zhu, Jiaqi, Ma, Rong |
| author_sort | liu, shuang |
| container_issue | 3 |
| container_start_page | 0 |
| container_title | Bioscience Reports |
| container_volume | 39 |
| description | <jats:title>Abstract</jats:title> <jats:p>Tripartite motif containing 44 (TRIM44) has been reported to be up-regulated in multiple aggressive malignant tumors. However, its expression status and clinical significance in cervical cancer remain unknown. The purpose of this study was to investigate the clinical significance of TRIM44 expression and the prognosis in patients with cervical cancer (CC). Fresh frozen tissues from 5 samples of CC and 4 normal cervical tissues were analyzed for TRIM44 expression using RT- PCR and Western blot analysis. 122 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry. TRIM44 expression was found to be significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues (P&lt;0.001). Statistical analysis showed that TRIM44 expression was significantly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly expressing TRIM44 have significantly shorter overall survival (OS) (P=0.006) and disease-free survival (DFS) (P=0.002). Furthermore, multivariate Cox analysis showed TRIM44 was an independent risk factor for poor prognosis. Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer.</jats:p> |
| doi_str_mv | 10.1042/bsr20181639 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Chemie und Pharmazie, Physik |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTYzOQ |
| imprint | Portland Press Ltd., 2019 |
| imprint_str_mv | Portland Press Ltd., 2019 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 0144-8463, 1573-4935 |
| issn_str_mv | 0144-8463, 1573-4935 |
| language | English |
| last_indexed | 2024-03-01T14:44:52.883Z |
| match_str | liu2019hightrim44expressionasavaluablebiomarkerfordiagnosisandprognosisincervicalcancer |
| mega_collection | Portland Press Ltd. (CrossRef) |
| physical | |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Portland Press Ltd. |
| record_format | ai |
| recordtype | ai |
| series | Bioscience Reports |
| source_id | 49 |
| spelling | Liu, Shuang Meng, Fanling Ding, Jing Ji, Hongying Lin, Mu Zhu, Jiaqi Ma, Rong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181639 <jats:title>Abstract</jats:title> <jats:p>Tripartite motif containing 44 (TRIM44) has been reported to be up-regulated in multiple aggressive malignant tumors. However, its expression status and clinical significance in cervical cancer remain unknown. The purpose of this study was to investigate the clinical significance of TRIM44 expression and the prognosis in patients with cervical cancer (CC). Fresh frozen tissues from 5 samples of CC and 4 normal cervical tissues were analyzed for TRIM44 expression using RT- PCR and Western blot analysis. 122 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry. TRIM44 expression was found to be significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues (P&lt;0.001). Statistical analysis showed that TRIM44 expression was significantly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly expressing TRIM44 have significantly shorter overall survival (OS) (P=0.006) and disease-free survival (DFS) (P=0.002). Furthermore, multivariate Cox analysis showed TRIM44 was an independent risk factor for poor prognosis. Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer.</jats:p> High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer Bioscience Reports |
| spellingShingle | Liu, Shuang, Meng, Fanling, Ding, Jing, Ji, Hongying, Lin, Mu, Zhu, Jiaqi, Ma, Rong, Bioscience Reports, High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_full | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_fullStr | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_full_unstemmed | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_short | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_sort | high trim44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| title_unstemmed | High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181639 |