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Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Bioscience Reports, 38, 2018, 6 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
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| Schlagwörter: |
| author_facet |
Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping |
|---|---|
| author |
Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping |
| spellingShingle |
Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping Bioscience Reports Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
wang, xiong |
| spelling |
Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181384 <jats:p>Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2 knockdown in the U2OS cells induced apoptosis by increasing the level of Bax and decreasing the level of Bcl2. These results suggested that RTKN2 is involved in the progression of human osteosarcoma, and may be a potential therapeutic target.</jats:p> Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells Bioscience Reports |
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| title |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_unstemmed |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_full |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_fullStr |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_full_unstemmed |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_short |
Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_sort |
rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20181384 |
| publishDate |
2018 |
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|
| description |
<jats:p>Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2 knockdown in the U2OS cells induced apoptosis by increasing the level of Bax and decreasing the level of Bcl2. These results suggested that RTKN2 is involved in the progression of human osteosarcoma, and may be a potential therapeutic target.</jats:p> |
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| author | Wang, Xiong, Zhang, Lei, Wang, Wenji, Wang, Yuchen, Chen, Ye, Xie, Ruimin, Li, Xiang, Wang, Yongping |
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| description | <jats:p>Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2 knockdown in the U2OS cells induced apoptosis by increasing the level of Bax and decreasing the level of Bcl2. These results suggested that RTKN2 is involved in the progression of human osteosarcoma, and may be a potential therapeutic target.</jats:p> |
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| spelling | Wang, Xiong Zhang, Lei Wang, Wenji Wang, Yuchen Chen, Ye Xie, Ruimin Li, Xiang Wang, Yongping 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181384 <jats:p>Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2 knockdown in the U2OS cells induced apoptosis by increasing the level of Bax and decreasing the level of Bcl2. These results suggested that RTKN2 is involved in the progression of human osteosarcoma, and may be a potential therapeutic target.</jats:p> Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells Bioscience Reports |
| spellingShingle | Wang, Xiong, Zhang, Lei, Wang, Wenji, Wang, Yuchen, Chen, Ye, Xie, Ruimin, Li, Xiang, Wang, Yongping, Bioscience Reports, Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_full | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_fullStr | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_full_unstemmed | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_short | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_sort | rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| title_unstemmed | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181384 |