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SAA1 gene polymorphisms in osteoporosis patients
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Bioscience Reports, 39, 2019, 2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei |
|---|---|
| author |
Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei |
| spellingShingle |
Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei Bioscience Reports SAA1 gene polymorphisms in osteoporosis patients Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
zhou, xindie |
| spelling |
Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181031 <jats:title>Abstract</jats:title> <jats:p>Background: Serum amyloid A (SAA1) is an apolipoprotein that maintains glucose and lipid homeostasis. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). Methods: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915) were genotyped using MALDI TOF MS. Results: There were no differences in the rs183978373 and rs12218 polymorphisms between the osteoporosis group and controls. The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Haplotype analysis revealed that the ATT haplotype had a significant correlation with a decreased risk of osteoporosis. Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.</jats:p> <i>SAA1</i> gene polymorphisms in osteoporosis patients Bioscience Reports |
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SAA1 gene polymorphisms in osteoporosis patients |
| title_unstemmed |
SAA1 gene polymorphisms in osteoporosis patients |
| title_full |
SAA1 gene polymorphisms in osteoporosis patients |
| title_fullStr |
SAA1 gene polymorphisms in osteoporosis patients |
| title_full_unstemmed |
SAA1 gene polymorphisms in osteoporosis patients |
| title_short |
SAA1 gene polymorphisms in osteoporosis patients |
| title_sort |
<i>saa1</i> gene polymorphisms in osteoporosis patients |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
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http://dx.doi.org/10.1042/bsr20181031 |
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2019 |
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|
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<jats:title>Abstract</jats:title>
<jats:p>Background: Serum amyloid A (SAA1) is an apolipoprotein that maintains glucose and lipid homeostasis. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). Methods: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915) were genotyped using MALDI TOF MS. Results: There were no differences in the rs183978373 and rs12218 polymorphisms between the osteoporosis group and controls. The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Haplotype analysis revealed that the ATT haplotype had a significant correlation with a decreased risk of osteoporosis. Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.</jats:p> |
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| author | Zhou, Xindie, Li, Jin, Jiang, Lifeng, Zhou, Dong, Wu, Lidong, Huang, Yong, Xu, Nanwei |
| author_facet | Zhou, Xindie, Li, Jin, Jiang, Lifeng, Zhou, Dong, Wu, Lidong, Huang, Yong, Xu, Nanwei, Zhou, Xindie, Li, Jin, Jiang, Lifeng, Zhou, Dong, Wu, Lidong, Huang, Yong, Xu, Nanwei |
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| description | <jats:title>Abstract</jats:title> <jats:p>Background: Serum amyloid A (SAA1) is an apolipoprotein that maintains glucose and lipid homeostasis. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). Methods: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915) were genotyped using MALDI TOF MS. Results: There were no differences in the rs183978373 and rs12218 polymorphisms between the osteoporosis group and controls. The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Haplotype analysis revealed that the ATT haplotype had a significant correlation with a decreased risk of osteoporosis. Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.</jats:p> |
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| spelling | Zhou, Xindie Li, Jin Jiang, Lifeng Zhou, Dong Wu, Lidong Huang, Yong Xu, Nanwei 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181031 <jats:title>Abstract</jats:title> <jats:p>Background: Serum amyloid A (SAA1) is an apolipoprotein that maintains glucose and lipid homeostasis. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). Methods: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915) were genotyped using MALDI TOF MS. Results: There were no differences in the rs183978373 and rs12218 polymorphisms between the osteoporosis group and controls. The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Haplotype analysis revealed that the ATT haplotype had a significant correlation with a decreased risk of osteoporosis. Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.</jats:p> <i>SAA1</i> gene polymorphisms in osteoporosis patients Bioscience Reports |
| spellingShingle | Zhou, Xindie, Li, Jin, Jiang, Lifeng, Zhou, Dong, Wu, Lidong, Huang, Yong, Xu, Nanwei, Bioscience Reports, SAA1 gene polymorphisms in osteoporosis patients, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | SAA1 gene polymorphisms in osteoporosis patients |
| title_full | SAA1 gene polymorphisms in osteoporosis patients |
| title_fullStr | SAA1 gene polymorphisms in osteoporosis patients |
| title_full_unstemmed | SAA1 gene polymorphisms in osteoporosis patients |
| title_short | SAA1 gene polymorphisms in osteoporosis patients |
| title_sort | <i>saa1</i> gene polymorphisms in osteoporosis patients |
| title_unstemmed | SAA1 gene polymorphisms in osteoporosis patients |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181031 |