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Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Biochemical Journal, 345, 2000, 3, S. 749-757 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
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| Schlagwörter: |
| author_facet |
YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang |
|---|---|
| author |
YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang |
| spellingShingle |
YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang Biochemical Journal Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I Cell Biology Molecular Biology Biochemistry |
| author_sort |
yan, xiumin |
| spelling |
YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj3450749 <jats:p>Retinoblastoma protein (Rb) is an important regulator of vertebrate cell cycle and development. It functions through a direct interaction with protein factors involved in cell cycle progression and differentiation. In the present study we characterized a novel Rb-associated protein, Cream1, which bound to Rb specifically through a C-terminal region. Cream1 contained 959 amino acid residues and migrated as a protein of approx. 120 kDa on SDS/PAGE. It was a widely expressed nuclear protein with a nuclear localization signal resembling that of the large T antigen of simian virus 40. Its primary sequence was characteristic of five direct repeats that were similar to, but distinct from, those of TFII-I, a multifunctional transcription regulator. Three additional regions were also highly conserved in both proteins. Cream1 exhibited an activation activity that was attributed to its N-terminal portion when assayed in yeast. Its relationship with the muscle-enhancer-binding protein MusTRD1 further suggests a role in regulating gene expression. The structural gene, CREAM1, contained 27 exons and spanned more than 150 kb. It was located at human chromosome 7q11.23 in a region deleted for Williams' syndrome, a neurodevelopmental disease with multisystem abnormalities, implying its involvement in certain disorders. Taken together, our results suggest that Cream1 might serve as a positive transcription regulator under the control of Rb.</jats:p> Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I Biochemical Journal |
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| title |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_unstemmed |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_full |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_fullStr |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_full_unstemmed |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_short |
Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_sort |
characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator tfii-i |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj3450749 |
| publishDate |
2000 |
| physical |
749-757 |
| description |
<jats:p>Retinoblastoma protein (Rb) is an important regulator of vertebrate cell cycle and development. It functions through a direct interaction with protein factors involved in cell cycle progression and differentiation. In the present study we characterized a novel Rb-associated protein, Cream1, which bound to Rb specifically through a C-terminal region. Cream1 contained 959 amino acid residues and migrated as a protein of approx. 120 kDa on SDS/PAGE. It was a widely expressed nuclear protein with a nuclear localization signal resembling that of the large T antigen of simian virus 40. Its primary sequence was characteristic of five direct repeats that were similar to, but distinct from, those of TFII-I, a multifunctional transcription regulator. Three additional regions were also highly conserved in both proteins. Cream1 exhibited an activation activity that was attributed to its N-terminal portion when assayed in yeast. Its relationship with the muscle-enhancer-binding protein MusTRD1 further suggests a role in regulating gene expression. The structural gene, CREAM1, contained 27 exons and spanned more than 150 kb. It was located at human chromosome 7q11.23 in a region deleted for Williams' syndrome, a neurodevelopmental disease with multisystem abnormalities, implying its involvement in certain disorders. Taken together, our results suggest that Cream1 might serve as a positive transcription regulator under the control of Rb.</jats:p> |
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| author | YAN, Xiumin, ZHAO, Xiangshan, QIAN, Min, GUO, Ning, GONG, Xiaohua, ZHU, Xueliang |
| author_facet | YAN, Xiumin, ZHAO, Xiangshan, QIAN, Min, GUO, Ning, GONG, Xiaohua, ZHU, Xueliang, YAN, Xiumin, ZHAO, Xiangshan, QIAN, Min, GUO, Ning, GONG, Xiaohua, ZHU, Xueliang |
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| description | <jats:p>Retinoblastoma protein (Rb) is an important regulator of vertebrate cell cycle and development. It functions through a direct interaction with protein factors involved in cell cycle progression and differentiation. In the present study we characterized a novel Rb-associated protein, Cream1, which bound to Rb specifically through a C-terminal region. Cream1 contained 959 amino acid residues and migrated as a protein of approx. 120 kDa on SDS/PAGE. It was a widely expressed nuclear protein with a nuclear localization signal resembling that of the large T antigen of simian virus 40. Its primary sequence was characteristic of five direct repeats that were similar to, but distinct from, those of TFII-I, a multifunctional transcription regulator. Three additional regions were also highly conserved in both proteins. Cream1 exhibited an activation activity that was attributed to its N-terminal portion when assayed in yeast. Its relationship with the muscle-enhancer-binding protein MusTRD1 further suggests a role in regulating gene expression. The structural gene, CREAM1, contained 27 exons and spanned more than 150 kb. It was located at human chromosome 7q11.23 in a region deleted for Williams' syndrome, a neurodevelopmental disease with multisystem abnormalities, implying its involvement in certain disorders. Taken together, our results suggest that Cream1 might serve as a positive transcription regulator under the control of Rb.</jats:p> |
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| spelling | YAN, Xiumin ZHAO, Xiangshan QIAN, Min GUO, Ning GONG, Xiaohua ZHU, Xueliang 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj3450749 <jats:p>Retinoblastoma protein (Rb) is an important regulator of vertebrate cell cycle and development. It functions through a direct interaction with protein factors involved in cell cycle progression and differentiation. In the present study we characterized a novel Rb-associated protein, Cream1, which bound to Rb specifically through a C-terminal region. Cream1 contained 959 amino acid residues and migrated as a protein of approx. 120 kDa on SDS/PAGE. It was a widely expressed nuclear protein with a nuclear localization signal resembling that of the large T antigen of simian virus 40. Its primary sequence was characteristic of five direct repeats that were similar to, but distinct from, those of TFII-I, a multifunctional transcription regulator. Three additional regions were also highly conserved in both proteins. Cream1 exhibited an activation activity that was attributed to its N-terminal portion when assayed in yeast. Its relationship with the muscle-enhancer-binding protein MusTRD1 further suggests a role in regulating gene expression. The structural gene, CREAM1, contained 27 exons and spanned more than 150 kb. It was located at human chromosome 7q11.23 in a region deleted for Williams' syndrome, a neurodevelopmental disease with multisystem abnormalities, implying its involvement in certain disorders. Taken together, our results suggest that Cream1 might serve as a positive transcription regulator under the control of Rb.</jats:p> Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I Biochemical Journal |
| spellingShingle | YAN, Xiumin, ZHAO, Xiangshan, QIAN, Min, GUO, Ning, GONG, Xiaohua, ZHU, Xueliang, Biochemical Journal, Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I, Cell Biology, Molecular Biology, Biochemistry |
| title | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_full | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_fullStr | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_full_unstemmed | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_short | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| title_sort | characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator tfii-i |
| title_unstemmed | Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj3450749 |