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Phosphonomethyl analogues of hexose phosphates
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Biochemical Journal, 155, 1976, 2, S. 433-441 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Webster, D Jondorf, W. R Dixon, H B. F. Webster, D Jondorf, W. R Dixon, H B. F. |
|---|---|
| author |
Webster, D Jondorf, W. R Dixon, H B. F. |
| spellingShingle |
Webster, D Jondorf, W. R Dixon, H B. F. Biochemical Journal Phosphonomethyl analogues of hexose phosphates Cell Biology Molecular Biology Biochemistry |
| author_sort |
webster, d |
| spelling |
Webster, D Jondorf, W. R Dixon, H B. F. 0264-6021 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj1550433 <jats:p>The analogue of fructose 1,6-bisphosphate in which the phosphate group, -O-PO3H2, on C-6 is replaced by the phosphonomethyl group, -CH2-PO3H2, was made enzymically from the corresponding analogue of 3-phosphoglycerate. It was a substrate for aldolase, which was used to form it, but not for fructose 1,6-bisphosphatase. It was hydrolysed chemically to yield the corresponding analogue of fructose 6-phosphate [i.e. 6-deoxy-6-(phosphonomethyl)-D-fructose, or, more strictly, 6,7-dideoxy-7-phosphono-D-arabino-2-heptulose]. This proved to be a substrate for the sequential actions of glucose 6-phosphate isomerase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Thus seven out of the nine enzymes of the glycolytic and pentose phosphate pathways so far tested catalyse the reactions of the phosphonomethyl isosteres of their substrates.</jats:p> Phosphonomethyl analogues of hexose phosphates Biochemical Journal |
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Portland Press Ltd., 1976 |
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Portland Press Ltd., 1976 |
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0264-6021 |
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Biochemical Journal |
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49 |
| title |
Phosphonomethyl analogues of hexose phosphates |
| title_unstemmed |
Phosphonomethyl analogues of hexose phosphates |
| title_full |
Phosphonomethyl analogues of hexose phosphates |
| title_fullStr |
Phosphonomethyl analogues of hexose phosphates |
| title_full_unstemmed |
Phosphonomethyl analogues of hexose phosphates |
| title_short |
Phosphonomethyl analogues of hexose phosphates |
| title_sort |
phosphonomethyl analogues of hexose phosphates |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj1550433 |
| publishDate |
1976 |
| physical |
433-441 |
| description |
<jats:p>The analogue of fructose 1,6-bisphosphate in which the phosphate group, -O-PO3H2, on C-6 is replaced by the phosphonomethyl group, -CH2-PO3H2, was made enzymically from the corresponding analogue of 3-phosphoglycerate. It was a substrate for aldolase, which was used to form it, but not for fructose 1,6-bisphosphatase. It was hydrolysed chemically to yield the corresponding analogue of fructose 6-phosphate [i.e. 6-deoxy-6-(phosphonomethyl)-D-fructose, or, more strictly, 6,7-dideoxy-7-phosphono-D-arabino-2-heptulose]. This proved to be a substrate for the sequential actions of glucose 6-phosphate isomerase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Thus seven out of the nine enzymes of the glycolytic and pentose phosphate pathways so far tested catalyse the reactions of the phosphonomethyl isosteres of their substrates.</jats:p> |
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| author | Webster, D, Jondorf, W. R, Dixon, H B. F. |
| author_facet | Webster, D, Jondorf, W. R, Dixon, H B. F., Webster, D, Jondorf, W. R, Dixon, H B. F. |
| author_sort | webster, d |
| container_issue | 2 |
| container_start_page | 433 |
| container_title | Biochemical Journal |
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| description | <jats:p>The analogue of fructose 1,6-bisphosphate in which the phosphate group, -O-PO3H2, on C-6 is replaced by the phosphonomethyl group, -CH2-PO3H2, was made enzymically from the corresponding analogue of 3-phosphoglycerate. It was a substrate for aldolase, which was used to form it, but not for fructose 1,6-bisphosphatase. It was hydrolysed chemically to yield the corresponding analogue of fructose 6-phosphate [i.e. 6-deoxy-6-(phosphonomethyl)-D-fructose, or, more strictly, 6,7-dideoxy-7-phosphono-D-arabino-2-heptulose]. This proved to be a substrate for the sequential actions of glucose 6-phosphate isomerase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Thus seven out of the nine enzymes of the glycolytic and pentose phosphate pathways so far tested catalyse the reactions of the phosphonomethyl isosteres of their substrates.</jats:p> |
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| imprint | Portland Press Ltd., 1976 |
| imprint_str_mv | Portland Press Ltd., 1976 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 0264-6021 |
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| language | English |
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| mega_collection | Portland Press Ltd. (CrossRef) |
| physical | 433-441 |
| publishDate | 1976 |
| publishDateSort | 1976 |
| publisher | Portland Press Ltd. |
| record_format | ai |
| recordtype | ai |
| series | Biochemical Journal |
| source_id | 49 |
| spelling | Webster, D Jondorf, W. R Dixon, H B. F. 0264-6021 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj1550433 <jats:p>The analogue of fructose 1,6-bisphosphate in which the phosphate group, -O-PO3H2, on C-6 is replaced by the phosphonomethyl group, -CH2-PO3H2, was made enzymically from the corresponding analogue of 3-phosphoglycerate. It was a substrate for aldolase, which was used to form it, but not for fructose 1,6-bisphosphatase. It was hydrolysed chemically to yield the corresponding analogue of fructose 6-phosphate [i.e. 6-deoxy-6-(phosphonomethyl)-D-fructose, or, more strictly, 6,7-dideoxy-7-phosphono-D-arabino-2-heptulose]. This proved to be a substrate for the sequential actions of glucose 6-phosphate isomerase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Thus seven out of the nine enzymes of the glycolytic and pentose phosphate pathways so far tested catalyse the reactions of the phosphonomethyl isosteres of their substrates.</jats:p> Phosphonomethyl analogues of hexose phosphates Biochemical Journal |
| spellingShingle | Webster, D, Jondorf, W. R, Dixon, H B. F., Biochemical Journal, Phosphonomethyl analogues of hexose phosphates, Cell Biology, Molecular Biology, Biochemistry |
| title | Phosphonomethyl analogues of hexose phosphates |
| title_full | Phosphonomethyl analogues of hexose phosphates |
| title_fullStr | Phosphonomethyl analogues of hexose phosphates |
| title_full_unstemmed | Phosphonomethyl analogues of hexose phosphates |
| title_short | Phosphonomethyl analogues of hexose phosphates |
| title_sort | phosphonomethyl analogues of hexose phosphates |
| title_unstemmed | Phosphonomethyl analogues of hexose phosphates |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj1550433 |