SOLR
| _version_ |
1797365279741706240 |
| author |
Xu, Haifeng |
| author2 |
Schmidt, Oliver G., Schmidt, Oliver G., Reinhardt, Klaus |
| author2_role |
, , |
| author2_variant |
o g s og ogs, o g s og ogs, k r kr |
| author_facet |
Xu, Haifeng, Schmidt, Oliver G., Schmidt, Oliver G., Reinhardt, Klaus |
| author_role |
|
| author_sort |
Xu, Haifeng |
| author_variant |
h x hx |
| building |
Library A |
| collection |
sid-22-col-qucosa |
| contents |
Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one potential solution is to incorporate micromotors with biological materials as the combination of functional biological entities and smart artificial parts represents a manipulable and biologically friendly approach. This dissertation focuses on the development of custom-designed micromotors combined with sperm and their potential applications on targeted diseases treatment. By means of 2D and 3D lithography methods, microstructures with complex configurations can be fabricated for specific demands. Bovine and human sperm are both for the first time explored as drug carriers thanks to their high encapsulation efficiency of hydrophilic drugs, their powerful self-propulsion and their improved drug-uptake relying on the somatic-cell fusion ability. The hybrid micromotors containing drug loaded sperm and constructed artificial enhancements can be self-propelled by the sperm flagella and remotely guided and released to the target at high precision by employing weak external magnetic fields. As a result, micromotors based on both bovine and human sperm show significant anticancer effect. The application here can be further broadened to other biological environments, in particular to the blood stream, showing the potential on the treatment of blood diseases like blood clotting. Finally, to enhance the treatment efficiency, in particular to control sperm number and drug dose, three strategies are demonstrated to transport swarms of sperm. This research paves the way for the precision medicine based on engineered sperm-based micromotors. |
| dewey-full |
624 |
| dewey-hundreds |
600 - Technology (Applied sciences) |
| dewey-ones |
624 - Civil engineering |
| dewey-raw |
624 |
| dewey-search |
624 |
| dewey-sort |
3624 |
| dewey-tens |
620 - Engineering and allied operations |
| facet_avail |
Online, Free |
| finc_class_facet |
Technik |
| fincclass_txtF_mv |
engineering-civil, engineering-process, technology |
| format |
eBook, Thesis |
| format_access_txtF_mv |
Thesis |
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Thesis, Book, E-Book |
| format_de15 |
Thesis, Book, E-Book |
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Buch, Buch |
| format_detail_txtF_mv |
text-online-monograph-independent-thesis |
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e-Book |
| format_finc |
Book, E-Book, Thesis |
| format_legacy |
Thesis, Book |
| format_legacy_nrw |
Thesis, Book, E-Book |
| format_nrw |
Thesis, Book, E-Book |
| format_strict_txtF_mv |
E-Thesis |
| genre |
Hochschulschrift gnd-content |
| genre_facet |
Hochschulschrift |
| geogr_code |
not assigned |
| geogr_code_person |
not assigned |
| id |
22-ch1-qucosa2-710484 |
| illustrated |
Not Illustrated |
| imprint |
Online-Ausg., 2020 |
| imprint_str_mv |
Online-Ausg.: 2020 |
| institution |
DE-105, DE-Gla1, DE-Brt1, DE-D161, DE-540, DE-Pl11, DE-Rs1, DE-Bn3, DE-Zi4, DE-Zwi2, DE-D117, DE-Mh31, DE-D275, DE-Ch1, DE-15, DE-D13, DE-L242, DE-L229, DE-L328 |
| is_hierarchy_id |
|
| is_hierarchy_title |
|
| language |
English |
| last_indexed |
2024-04-26T03:11:41.886Z |
| match_str |
xu2020customdesignedbiohybridmicromotorforpotentialdiseasetreatment |
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Qucosa |
| publishDateSort |
2020 |
| record_format |
marcfinc |
| record_id |
ch1-qucosa2-710484 |
| recordtype |
marcfinc |
| rvk_facet |
No subject assigned |
| source_id |
22 |
| spelling |
Xu, Haifeng, Custom-Designed Biohybrid Micromotor for Potential Disease Treatment, txt, nc, Online-Ausg. 2020 Online-Ressource (Text) Technische Universität Chemnitz, Dissertation Technische Universität Chemnitz 2019, Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one potential solution is to incorporate micromotors with biological materials as the combination of functional biological entities and smart artificial parts represents a manipulable and biologically friendly approach. This dissertation focuses on the development of custom-designed micromotors combined with sperm and their potential applications on targeted diseases treatment. By means of 2D and 3D lithography methods, microstructures with complex configurations can be fabricated for specific demands. Bovine and human sperm are both for the first time explored as drug carriers thanks to their high encapsulation efficiency of hydrophilic drugs, their powerful self-propulsion and their improved drug-uptake relying on the somatic-cell fusion ability. The hybrid micromotors containing drug loaded sperm and constructed artificial enhancements can be self-propelled by the sperm flagella and remotely guided and released to the target at high precision by employing weak external magnetic fields. As a result, micromotors based on both bovine and human sperm show significant anticancer effect. The application here can be further broadened to other biological environments, in particular to the blood stream, showing the potential on the treatment of blood diseases like blood clotting. Finally, to enhance the treatment efficiency, in particular to control sperm number and drug dose, three strategies are demonstrated to transport swarms of sperm. This research paves the way for the precision medicine based on engineered sperm-based micromotors., Micromotors, Sperm, Drug Delivery, Cancer Treatment, Blood Diseases, Untethered Robotics, Kleinstmotor, Robotik, Biohybrides System, Krankheit, Behandlung, Hochschulschrift gnd-content, Schmidt, Oliver G., Reinhardt, Klaus, text/html https://nbn-resolving.org/urn:nbn:de:bsz:ch1-qucosa2-710484 Online-Zugriff |
| spellingShingle |
Xu, Haifeng, Custom-Designed Biohybrid Micromotor for Potential Disease Treatment, Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one potential solution is to incorporate micromotors with biological materials as the combination of functional biological entities and smart artificial parts represents a manipulable and biologically friendly approach. This dissertation focuses on the development of custom-designed micromotors combined with sperm and their potential applications on targeted diseases treatment. By means of 2D and 3D lithography methods, microstructures with complex configurations can be fabricated for specific demands. Bovine and human sperm are both for the first time explored as drug carriers thanks to their high encapsulation efficiency of hydrophilic drugs, their powerful self-propulsion and their improved drug-uptake relying on the somatic-cell fusion ability. The hybrid micromotors containing drug loaded sperm and constructed artificial enhancements can be self-propelled by the sperm flagella and remotely guided and released to the target at high precision by employing weak external magnetic fields. As a result, micromotors based on both bovine and human sperm show significant anticancer effect. The application here can be further broadened to other biological environments, in particular to the blood stream, showing the potential on the treatment of blood diseases like blood clotting. Finally, to enhance the treatment efficiency, in particular to control sperm number and drug dose, three strategies are demonstrated to transport swarms of sperm. This research paves the way for the precision medicine based on engineered sperm-based micromotors., Micromotors, Sperm, Drug Delivery, Cancer Treatment, Blood Diseases, Untethered Robotics, Kleinstmotor, Robotik, Biohybrides System, Krankheit, Behandlung, Hochschulschrift |
| title |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_auth |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_full |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_fullStr |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_full_unstemmed |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_short |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| title_sort |
custom-designed biohybrid micromotor for potential disease treatment |
| title_unstemmed |
Custom-Designed Biohybrid Micromotor for Potential Disease Treatment |
| topic |
Micromotors, Sperm, Drug Delivery, Cancer Treatment, Blood Diseases, Untethered Robotics, Kleinstmotor, Robotik, Biohybrides System, Krankheit, Behandlung, Hochschulschrift |
| topic_facet |
Micromotors, Sperm, Drug Delivery, Cancer Treatment, Blood Diseases, Untethered Robotics, Kleinstmotor, Robotik, Biohybrides System, Krankheit, Behandlung, Hochschulschrift |
| url |
https://nbn-resolving.org/urn:nbn:de:bsz:ch1-qucosa2-710484 |
| urn |
urn:nbn:de:bsz:ch1-qucosa2-710484 |
| work_keys_str_mv |
AT xuhaifeng customdesignedbiohybridmicromotorforpotentialdiseasetreatment, AT schmidtoliverg customdesignedbiohybridmicromotorforpotentialdiseasetreatment, AT reinhardtklaus customdesignedbiohybridmicromotorforpotentialdiseasetreatment |
