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A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world. |
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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy edited by Vassil St.Georgiev, Gail Skowron, Richard Ogden, Joep M. A. Lange, Totowa, NJ Humana Press Inc 2006, Online-Ressource (digital), Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Infectious Disease, SpringerLink Bücher, Includes bibliographical references and index, A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world., Medicine, Emerging infectious diseases, Medicine & Public Health, Acquired Immunodeficiency Syndrome drug therapy, HIV Infections drug therapy, Reverse Transcriptase Inhibitors therapeutic use, s (DE-588)4203852-2 (DE-627)105147915 (DE-576)210157976 HIV-Infektion gnd, s (DE-588)4221839-1 (DE-627)105006785 (DE-576)21027624X Reverse Transkriptase gnd, (DE-627), s (DE-588)4112470-4 (DE-627)105836931 (DE-576)209468262 Aids gnd, Georgiev, Vassil St. (DE-588)121687732 (DE-627)081468296 (DE-576)16436417X oth, Skowron, Gail oth, Ogden, Richard oth, Lange, Joep M. A. (DE-627)1244668311 (DE-576)174668317 oth, 9781588296498, Buchausg. u.d.T. 978-1-58829-649-8, https://doi.org/10.1007/978-1-59745-085-0 Verlag Volltext, http://dx.doi.org/10.1007/978-1-59745-085-0 Resolving-System lizenzpflichtig Volltext, https://swbplus.bsz-bw.de/bsz280691491kap.htm V:DE-576 text/html Kapitel 2, https://swbplus.bsz-bw.de/bsz280691491vor.htm V:DE-576 text/html Einführung/Vorwort, https://swbplus.bsz-bw.de/bsz280691491inh.htm V:DE-576 text/html Inhaltsverzeichnis, https://swbplus.bsz-bw.de/bsz280691491cov.jpg V:DE-576 text/html Cover, (DE-627)556581881 |
spellingShingle |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world., Medicine, Emerging infectious diseases, Medicine & Public Health, Acquired Immunodeficiency Syndrome drug therapy, HIV Infections drug therapy, Reverse Transcriptase Inhibitors therapeutic use, HIV-Infektion, Reverse Transkriptase, Aids |
title |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy |
title_auth |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy |
title_full |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy edited by Vassil St.Georgiev, Gail Skowron, Richard Ogden, Joep M. A. Lange |
title_fullStr |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy edited by Vassil St.Georgiev, Gail Skowron, Richard Ogden, Joep M. A. Lange |
title_full_unstemmed |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy edited by Vassil St.Georgiev, Gail Skowron, Richard Ogden, Joep M. A. Lange |
title_short |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy |
title_sort |
reverse transcriptase inhibitors in hiv/aids therapy |
title_unstemmed |
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy |
topic |
Medicine, Emerging infectious diseases, Medicine & Public Health, Acquired Immunodeficiency Syndrome drug therapy, HIV Infections drug therapy, Reverse Transcriptase Inhibitors therapeutic use, HIV-Infektion, Reverse Transkriptase, Aids |
topic_facet |
Medicine, Emerging infectious diseases, Medicine & Public Health, Acquired Immunodeficiency Syndrome, HIV Infections, Reverse Transcriptase Inhibitors, drug therapy, therapeutic use, HIV-Infektion, Reverse Transkriptase, Aids |
url |
https://doi.org/10.1007/978-1-59745-085-0, http://dx.doi.org/10.1007/978-1-59745-085-0, https://swbplus.bsz-bw.de/bsz280691491kap.htm, https://swbplus.bsz-bw.de/bsz280691491vor.htm, https://swbplus.bsz-bw.de/bsz280691491inh.htm, https://swbplus.bsz-bw.de/bsz280691491cov.jpg |
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