author_facet Falougy, Hisham El
Filova, Barbora
Ostatnikova, Daniela
Bacova, Zuzana
Bakos, Jan
Falougy, Hisham El
Filova, Barbora
Ostatnikova, Daniela
Bacova, Zuzana
Bakos, Jan
author Falougy, Hisham El
Filova, Barbora
Ostatnikova, Daniela
Bacova, Zuzana
Bakos, Jan
spellingShingle Falougy, Hisham El
Filova, Barbora
Ostatnikova, Daniela
Bacova, Zuzana
Bakos, Jan
Endocrine Regulations
Neuronal morphology alterations in autism and possible role of oxytocin
Endocrinology
Endocrinology, Diabetes and Metabolism
author_sort falougy, hisham el
spelling Falougy, Hisham El Filova, Barbora Ostatnikova, Daniela Bacova, Zuzana Bakos, Jan 1336-0329 Walter de Gruyter GmbH Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.2478/enr-2019-0006 <jats:title>Abstract</jats:title> <jats:p>Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.</jats:p> Neuronal morphology alterations in autism and possible role of oxytocin Endocrine Regulations
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title Neuronal morphology alterations in autism and possible role of oxytocin
title_unstemmed Neuronal morphology alterations in autism and possible role of oxytocin
title_full Neuronal morphology alterations in autism and possible role of oxytocin
title_fullStr Neuronal morphology alterations in autism and possible role of oxytocin
title_full_unstemmed Neuronal morphology alterations in autism and possible role of oxytocin
title_short Neuronal morphology alterations in autism and possible role of oxytocin
title_sort neuronal morphology alterations in autism and possible role of oxytocin
topic Endocrinology
Endocrinology, Diabetes and Metabolism
url http://dx.doi.org/10.2478/enr-2019-0006
publishDate 2019
physical 46-54
description <jats:title>Abstract</jats:title> <jats:p>Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.</jats:p>
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author Falougy, Hisham El, Filova, Barbora, Ostatnikova, Daniela, Bacova, Zuzana, Bakos, Jan
author_facet Falougy, Hisham El, Filova, Barbora, Ostatnikova, Daniela, Bacova, Zuzana, Bakos, Jan, Falougy, Hisham El, Filova, Barbora, Ostatnikova, Daniela, Bacova, Zuzana, Bakos, Jan
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description <jats:title>Abstract</jats:title> <jats:p>Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.</jats:p>
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spelling Falougy, Hisham El Filova, Barbora Ostatnikova, Daniela Bacova, Zuzana Bakos, Jan 1336-0329 Walter de Gruyter GmbH Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.2478/enr-2019-0006 <jats:title>Abstract</jats:title> <jats:p>Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.</jats:p> Neuronal morphology alterations in autism and possible role of oxytocin Endocrine Regulations
spellingShingle Falougy, Hisham El, Filova, Barbora, Ostatnikova, Daniela, Bacova, Zuzana, Bakos, Jan, Endocrine Regulations, Neuronal morphology alterations in autism and possible role of oxytocin, Endocrinology, Endocrinology, Diabetes and Metabolism
title Neuronal morphology alterations in autism and possible role of oxytocin
title_full Neuronal morphology alterations in autism and possible role of oxytocin
title_fullStr Neuronal morphology alterations in autism and possible role of oxytocin
title_full_unstemmed Neuronal morphology alterations in autism and possible role of oxytocin
title_short Neuronal morphology alterations in autism and possible role of oxytocin
title_sort neuronal morphology alterations in autism and possible role of oxytocin
title_unstemmed Neuronal morphology alterations in autism and possible role of oxytocin
topic Endocrinology, Endocrinology, Diabetes and Metabolism
url http://dx.doi.org/10.2478/enr-2019-0006