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The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart
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| Zeitschriftentitel: | Serbian Journal of Experimental and Clinical Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Serbian Journal of Experimental and Clinical Research, 2017 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Walter de Gruyter GmbH
|
| Schlagwörter: |
| author_facet |
Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir |
|---|---|
| author |
Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir |
| spellingShingle |
Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir Serbian Journal of Experimental and Clinical Research The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart General Medicine |
| author_sort |
smigic, jelena |
| spelling |
Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr.2017-0003 <jats:title>Abstract</jats:title><jats:p>Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. Th e hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH<jats:sub>2</jats:sub>O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H<jats:sub>2</jats:sub>O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H<jats:sub>2</jats:sub>O) and hyperoxia (higher than 80 cm H<jats:sub>2</jats:sub>O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity.</jats:p> The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart Serbian Journal of Experimental and Clinical Research |
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| title |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_unstemmed |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_full |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_fullStr |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_full_unstemmed |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_short |
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_sort |
the effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1515/sjecr.2017-0003 |
| publishDate |
2017 |
| physical |
|
| description |
<jats:title>Abstract</jats:title><jats:p>Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. Th e hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH<jats:sub>2</jats:sub>O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H<jats:sub>2</jats:sub>O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H<jats:sub>2</jats:sub>O) and hyperoxia (higher than 80 cm H<jats:sub>2</jats:sub>O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity.</jats:p> |
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| author | Smigic, Jelena, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Nikolic, Tamara, Jeremic, Jovana, Sabo, Tibor, Jakovljevic, Vladimir |
| author_facet | Smigic, Jelena, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Nikolic, Tamara, Jeremic, Jovana, Sabo, Tibor, Jakovljevic, Vladimir, Smigic, Jelena, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Nikolic, Tamara, Jeremic, Jovana, Sabo, Tibor, Jakovljevic, Vladimir |
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| description | <jats:title>Abstract</jats:title><jats:p>Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. Th e hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH<jats:sub>2</jats:sub>O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H<jats:sub>2</jats:sub>O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H<jats:sub>2</jats:sub>O) and hyperoxia (higher than 80 cm H<jats:sub>2</jats:sub>O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity.</jats:p> |
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| spelling | Smigic, Jelena Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Nikolic, Tamara Jeremic, Jovana Sabo, Tibor Jakovljevic, Vladimir 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr.2017-0003 <jats:title>Abstract</jats:title><jats:p>Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. Th e hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH<jats:sub>2</jats:sub>O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H<jats:sub>2</jats:sub>O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H<jats:sub>2</jats:sub>O) and hyperoxia (higher than 80 cm H<jats:sub>2</jats:sub>O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity.</jats:p> The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart Serbian Journal of Experimental and Clinical Research |
| spellingShingle | Smigic, Jelena, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Nikolic, Tamara, Jeremic, Jovana, Sabo, Tibor, Jakovljevic, Vladimir, Serbian Journal of Experimental and Clinical Research, The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart, General Medicine |
| title | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_full | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_fullStr | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_full_unstemmed | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_short | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| title_sort | the effects of chronic administration of cisplatin on oxidative stress in the isolated rat heart |
| title_unstemmed | The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart |
| topic | General Medicine |
| url | http://dx.doi.org/10.1515/sjecr.2017-0003 |