author_facet Radonjic, Katarina
Stojic, Isidora
Zivkovic, Vladimir
Srejovic, Ivan
Jeremic, Nevena
Jakovljevic, Vladimir
Djuric, Dragan
Novokmet, Slobodan
Radonjic, Katarina
Stojic, Isidora
Zivkovic, Vladimir
Srejovic, Ivan
Jeremic, Nevena
Jakovljevic, Vladimir
Djuric, Dragan
Novokmet, Slobodan
author Radonjic, Katarina
Stojic, Isidora
Zivkovic, Vladimir
Srejovic, Ivan
Jeremic, Nevena
Jakovljevic, Vladimir
Djuric, Dragan
Novokmet, Slobodan
spellingShingle Radonjic, Katarina
Stojic, Isidora
Zivkovic, Vladimir
Srejovic, Ivan
Jeremic, Nevena
Jakovljevic, Vladimir
Djuric, Dragan
Novokmet, Slobodan
Serbian Journal of Experimental and Clinical Research
The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
General Medicine
author_sort radonjic, katarina
spelling Radonjic, Katarina Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Jeremic, Nevena Jakovljevic, Vladimir Djuric, Dragan Novokmet, Slobodan 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr-2016-0059 <jats:title>Abstract</jats:title> <jats:p>Interest for the clinical application of transition metal complexes as chemotherapeutic agents initially started with discovery of cisplatin. Despite the remarkable clinical success, cisplatin treatment is limited due to its resistance and side effects. Over the last 40 years, numerous transition metal complexes were synthesized and investigated in vitro and in vivo in order to establish a metallopharmaceutical that will exert less toxicity and equal or higher potency. We have compared the cardiotoxicity of 2 platinum complexes, one ligand, and a starting salt for complex synthesis using an experimental model of an isolated, perfused rat heart according to the Langendorfftechnique. The cardiotoxicity was assessed by comparison of oxidative stress induced following the perfusion of the following compounds: Dichloro(1,2-diaminocyclohexane)platinum(II), cisplatin, potassium-tetra-chloroplatinum(II) and 1,2-diaminocyclohexane, which were perfused at increasing concentrations from 10<jats:sup>−8</jats:sup> to 10<jats:sup>−4</jats:sup> M for 30 minutes. The oxidative stress was assessed by determination of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide from the coronary venous effluent. Our results showed that the levels of oxidative stress parameters were not significantly affected by perfusion with all the tested compounds and were not dose-dependent. These results could be of importance to further investigations concerning the effects of platinum-based potential anticancer drugs on the heart.</jats:p> The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart Serbian Journal of Experimental and Clinical Research
doi_str_mv 10.1515/sjecr-2016-0059
facet_avail Online
Free
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE2LTAwNTk
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE2LTAwNTk
institution DE-Rs1
DE-Pl11
DE-105
DE-14
DE-Ch1
DE-L229
DE-D275
DE-Bn3
DE-Brt1
DE-Zwi2
DE-D161
DE-Gla1
DE-Zi4
DE-15
imprint Walter de Gruyter GmbH, 2017
imprint_str_mv Walter de Gruyter GmbH, 2017
issn 2335-075X
1820-8665
issn_str_mv 2335-075X
1820-8665
language English
mega_collection Walter de Gruyter GmbH (CrossRef)
match_str radonjic2017theplatinumiicomplexesinducedoxidativestressofisolatedratheart
publishDateSort 2017
publisher Walter de Gruyter GmbH
recordtype ai
record_format ai
series Serbian Journal of Experimental and Clinical Research
source_id 49
title The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_unstemmed The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_full The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_fullStr The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_full_unstemmed The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_short The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_sort the platinum(ii) complexes induced oxidative stress of isolated rat heart
topic General Medicine
url http://dx.doi.org/10.1515/sjecr-2016-0059
publishDate 2017
physical 111-117
description <jats:title>Abstract</jats:title> <jats:p>Interest for the clinical application of transition metal complexes as chemotherapeutic agents initially started with discovery of cisplatin. Despite the remarkable clinical success, cisplatin treatment is limited due to its resistance and side effects. Over the last 40 years, numerous transition metal complexes were synthesized and investigated in vitro and in vivo in order to establish a metallopharmaceutical that will exert less toxicity and equal or higher potency. We have compared the cardiotoxicity of 2 platinum complexes, one ligand, and a starting salt for complex synthesis using an experimental model of an isolated, perfused rat heart according to the Langendorfftechnique. The cardiotoxicity was assessed by comparison of oxidative stress induced following the perfusion of the following compounds: Dichloro(1,2-diaminocyclohexane)platinum(II), cisplatin, potassium-tetra-chloroplatinum(II) and 1,2-diaminocyclohexane, which were perfused at increasing concentrations from 10<jats:sup>−8</jats:sup> to 10<jats:sup>−4</jats:sup> M for 30 minutes. The oxidative stress was assessed by determination of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide from the coronary venous effluent. Our results showed that the levels of oxidative stress parameters were not significantly affected by perfusion with all the tested compounds and were not dose-dependent. These results could be of importance to further investigations concerning the effects of platinum-based potential anticancer drugs on the heart.</jats:p>
container_issue 2
container_start_page 111
container_title Serbian Journal of Experimental and Clinical Research
container_volume 18
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792331975126679556
geogr_code not assigned
last_indexed 2024-03-01T13:49:30.017Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+Platinum%28II%29+Complexes+Induced+Oxidative+Stress+of+Isolated+Rat+Heart&rft.date=2017-06-01&genre=article&issn=1820-8665&volume=18&issue=2&spage=111&epage=117&pages=111-117&jtitle=Serbian+Journal+of+Experimental+and+Clinical+Research&atitle=The+Platinum%28II%29+Complexes+Induced+Oxidative+Stress+of+Isolated+Rat+Heart&aulast=Novokmet&aufirst=Slobodan&rft_id=info%3Adoi%2F10.1515%2Fsjecr-2016-0059&rft.language%5B0%5D=eng
SOLR
_version_ 1792331975126679556
author Radonjic, Katarina, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Jeremic, Nevena, Jakovljevic, Vladimir, Djuric, Dragan, Novokmet, Slobodan
author_facet Radonjic, Katarina, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Jeremic, Nevena, Jakovljevic, Vladimir, Djuric, Dragan, Novokmet, Slobodan, Radonjic, Katarina, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Jeremic, Nevena, Jakovljevic, Vladimir, Djuric, Dragan, Novokmet, Slobodan
author_sort radonjic, katarina
container_issue 2
container_start_page 111
container_title Serbian Journal of Experimental and Clinical Research
container_volume 18
description <jats:title>Abstract</jats:title> <jats:p>Interest for the clinical application of transition metal complexes as chemotherapeutic agents initially started with discovery of cisplatin. Despite the remarkable clinical success, cisplatin treatment is limited due to its resistance and side effects. Over the last 40 years, numerous transition metal complexes were synthesized and investigated in vitro and in vivo in order to establish a metallopharmaceutical that will exert less toxicity and equal or higher potency. We have compared the cardiotoxicity of 2 platinum complexes, one ligand, and a starting salt for complex synthesis using an experimental model of an isolated, perfused rat heart according to the Langendorfftechnique. The cardiotoxicity was assessed by comparison of oxidative stress induced following the perfusion of the following compounds: Dichloro(1,2-diaminocyclohexane)platinum(II), cisplatin, potassium-tetra-chloroplatinum(II) and 1,2-diaminocyclohexane, which were perfused at increasing concentrations from 10<jats:sup>−8</jats:sup> to 10<jats:sup>−4</jats:sup> M for 30 minutes. The oxidative stress was assessed by determination of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide from the coronary venous effluent. Our results showed that the levels of oxidative stress parameters were not significantly affected by perfusion with all the tested compounds and were not dose-dependent. These results could be of importance to further investigations concerning the effects of platinum-based potential anticancer drugs on the heart.</jats:p>
doi_str_mv 10.1515/sjecr-2016-0059
facet_avail Online, Free
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUxNS9zamVjci0yMDE2LTAwNTk
imprint Walter de Gruyter GmbH, 2017
imprint_str_mv Walter de Gruyter GmbH, 2017
institution DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15
issn 2335-075X, 1820-8665
issn_str_mv 2335-075X, 1820-8665
language English
last_indexed 2024-03-01T13:49:30.017Z
match_str radonjic2017theplatinumiicomplexesinducedoxidativestressofisolatedratheart
mega_collection Walter de Gruyter GmbH (CrossRef)
physical 111-117
publishDate 2017
publishDateSort 2017
publisher Walter de Gruyter GmbH
record_format ai
recordtype ai
series Serbian Journal of Experimental and Clinical Research
source_id 49
spelling Radonjic, Katarina Stojic, Isidora Zivkovic, Vladimir Srejovic, Ivan Jeremic, Nevena Jakovljevic, Vladimir Djuric, Dragan Novokmet, Slobodan 2335-075X 1820-8665 Walter de Gruyter GmbH General Medicine http://dx.doi.org/10.1515/sjecr-2016-0059 <jats:title>Abstract</jats:title> <jats:p>Interest for the clinical application of transition metal complexes as chemotherapeutic agents initially started with discovery of cisplatin. Despite the remarkable clinical success, cisplatin treatment is limited due to its resistance and side effects. Over the last 40 years, numerous transition metal complexes were synthesized and investigated in vitro and in vivo in order to establish a metallopharmaceutical that will exert less toxicity and equal or higher potency. We have compared the cardiotoxicity of 2 platinum complexes, one ligand, and a starting salt for complex synthesis using an experimental model of an isolated, perfused rat heart according to the Langendorfftechnique. The cardiotoxicity was assessed by comparison of oxidative stress induced following the perfusion of the following compounds: Dichloro(1,2-diaminocyclohexane)platinum(II), cisplatin, potassium-tetra-chloroplatinum(II) and 1,2-diaminocyclohexane, which were perfused at increasing concentrations from 10<jats:sup>−8</jats:sup> to 10<jats:sup>−4</jats:sup> M for 30 minutes. The oxidative stress was assessed by determination of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide from the coronary venous effluent. Our results showed that the levels of oxidative stress parameters were not significantly affected by perfusion with all the tested compounds and were not dose-dependent. These results could be of importance to further investigations concerning the effects of platinum-based potential anticancer drugs on the heart.</jats:p> The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart Serbian Journal of Experimental and Clinical Research
spellingShingle Radonjic, Katarina, Stojic, Isidora, Zivkovic, Vladimir, Srejovic, Ivan, Jeremic, Nevena, Jakovljevic, Vladimir, Djuric, Dragan, Novokmet, Slobodan, Serbian Journal of Experimental and Clinical Research, The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart, General Medicine
title The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_full The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_fullStr The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_full_unstemmed The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_short The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
title_sort the platinum(ii) complexes induced oxidative stress of isolated rat heart
title_unstemmed The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart
topic General Medicine
url http://dx.doi.org/10.1515/sjecr-2016-0059