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Childhood Seizures After Phototherapy
Saved in:
| Journal Title: | Pediatrics |
|---|---|
| Authors and Corporations: | , , , , |
| In: | Pediatrics, 142, 2018, 4 |
| Type of Resource: | E-Article |
| Language: | English |
| published: |
American Academy of Pediatrics (AAP)
|
| Subjects: |
| finc.format |
ElectronicArticle |
|---|---|
| finc.mega_collection |
American Academy of Pediatrics (AAP) (CrossRef) |
| finc.id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTU0Mi9wZWRzLjIwMTgtMDY0OA |
| finc.source_id |
49 |
| ris.type |
EJOUR |
| rft.atitle |
Childhood Seizures After Phototherapy |
| rft.epage |
0 |
| rft.genre |
article |
| rft.issn |
0031-4005 1098-4275 |
| rft.issue |
4 |
| rft.jtitle |
Pediatrics |
| rft.tpages |
0 |
| rft.pub |
American Academy of Pediatrics (AAP) |
| rft.date |
2018-10-01 |
| x.date |
2018-10-01T00:00:00Z |
| rft.spage |
0 |
| rft.volume |
142 |
| abstract |
<jats:sec>
<jats:title />
</jats:sec>
<jats:sec>
<jats:title>BACKGROUND AND OBJECTIVES:</jats:title>
<jats:p>In a recent Danish study, researchers found an increased risk of childhood epilepsy after phototherapy but only in boys. We investigated this association in a Kaiser Permanente Northern California cohort.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>METHODS:</jats:title>
<jats:p>From 499 642 infants born at ≥35 weeks’ gestation in 1995–2011 followed for ≥60 days, we excluded 1773 that exceeded exchange transfusion thresholds and 1237 with seizure diagnoses at &lt;60 days. We ascertained phototherapy, covariates, and outcomes from electronic records and existing databases. Our primary outcome was ≥1 encounter with a seizure diagnosis plus ≥1 prescription for an antiepileptic drug. We used Cox and Poisson models to adjust for bilirubin levels and other confounding variables.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS:</jats:title>
<jats:p>A total of 37 683 (7.6%) infants received any phototherapy. The mean (SD) follow-up time was 8.1 (5.2) years. The crude incidence rate per 1000 person-years of the primary outcome was 1.24 among phototherapy-exposed children and 0.76 among those unexposed (rate ratio: 1.63; 95% confidence interval [CI]: 1.44 to 1.85). The adjusted hazard ratio (aHR) was 1.22 (95% CI: 1.05 to 1.42; P = .009). Boys were at higher risk of seizures overall (aHR = 1.18; 95% CI: 1.10 to 1.27) and had a higher aHR for phototherapy (1.33; 95% CI: 1.10 to 1.61) than girls (1.07; 95% CI: 0.84 to 1.37), although effect modification by sex was not statistically significant (P = .17). The adjusted 10-year excess risks per 1000 were 2.4 (95% CI: 0.6 to 4.1) overall, 3.7 (95% CI: 1.2 to 6.1) in boys, and 0.8 (95% CI: −1.7 to 3.2) in girls.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS:</jats:title>
<jats:p>Phototherapy in newborns is associated with a small increased risk of childhood seizures, even after adjusting for bilirubin values, and the risk is more significant in boys.</jats:p>
</jats:sec> |
| authors |
Array
(
[rft.aulast] => Newman
[rft.aufirst] => Thomas B.
)
Array ( [rft.aulast] => Wu [rft.aufirst] => Yvonne W. ) Array ( [rft.aulast] => Kuzniewicz [rft.aufirst] => Michael W. ) Array ( [rft.aulast] => Grimes [rft.aufirst] => Barbara A. ) Array ( [rft.aulast] => McCulloch [rft.aufirst] => Charles E. ) |
| doi |
10.1542/peds.2018-0648 |
| languages |
eng |
| url |
http://dx.doi.org/10.1542/peds.2018-0648 |
| version |
0.9 |
| x.subjects |
Pediatrics, Perinatology and Child Health |
| x.type |
journal-article |
| x.oa |
1 |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fwww.hszg.de%3Agenerator&rft.title=Childhood+Seizures+After+Phototherapy&rft.date=2018-10-01&genre=article&issn=1098-4275&volume=142&issue=4&jtitle=Pediatrics&atitle=Childhood+Seizures+After+Phototherapy&aulast=McCulloch&aufirst=Charles+E.&rft_id=info%3Adoi%2F10.1542%2Fpeds.2018-0648&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1758657683524681728 |
| access_facet | Electronic Resources |
| author | Newman, Thomas B., Wu, Yvonne W., Kuzniewicz, Michael W., Grimes, Barbara A., McCulloch, Charles E. |
| author_facet | Newman, Thomas B., Wu, Yvonne W., Kuzniewicz, Michael W., Grimes, Barbara A., McCulloch, Charles E., Newman, Thomas B., Wu, Yvonne W., Kuzniewicz, Michael W., Grimes, Barbara A., McCulloch, Charles E. |
| author_sort | newman, thomas b. |
| branch_nrw | Electronic Resources |
| container_issue | 4 |
| container_start_page | 0 |
| container_title | Pediatrics |
| container_volume | 142 |
| description | <jats:sec> <jats:title /> </jats:sec> <jats:sec> <jats:title>BACKGROUND AND OBJECTIVES:</jats:title> <jats:p>In a recent Danish study, researchers found an increased risk of childhood epilepsy after phototherapy but only in boys. We investigated this association in a Kaiser Permanente Northern California cohort.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>From 499 642 infants born at ≥35 weeks’ gestation in 1995–2011 followed for ≥60 days, we excluded 1773 that exceeded exchange transfusion thresholds and 1237 with seizure diagnoses at &lt;60 days. We ascertained phototherapy, covariates, and outcomes from electronic records and existing databases. Our primary outcome was ≥1 encounter with a seizure diagnosis plus ≥1 prescription for an antiepileptic drug. We used Cox and Poisson models to adjust for bilirubin levels and other confounding variables.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p>A total of 37 683 (7.6%) infants received any phototherapy. The mean (SD) follow-up time was 8.1 (5.2) years. The crude incidence rate per 1000 person-years of the primary outcome was 1.24 among phototherapy-exposed children and 0.76 among those unexposed (rate ratio: 1.63; 95% confidence interval [CI]: 1.44 to 1.85). The adjusted hazard ratio (aHR) was 1.22 (95% CI: 1.05 to 1.42; P = .009). Boys were at higher risk of seizures overall (aHR = 1.18; 95% CI: 1.10 to 1.27) and had a higher aHR for phototherapy (1.33; 95% CI: 1.10 to 1.61) than girls (1.07; 95% CI: 0.84 to 1.37), although effect modification by sex was not statistically significant (P = .17). The adjusted 10-year excess risks per 1000 were 2.4 (95% CI: 0.6 to 4.1) overall, 3.7 (95% CI: 1.2 to 6.1) in boys, and 0.8 (95% CI: −1.7 to 3.2) in girls.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>Phototherapy in newborns is associated with a small increased risk of childhood seizures, even after adjusting for bilirubin values, and the risk is more significant in boys.</jats:p> </jats:sec> |
| doi_str_mv | 10.1542/peds.2018-0648 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTU0Mi9wZWRzLjIwMTgtMDY0OA |
| imprint | American Academy of Pediatrics (AAP), 2018 |
| imprint_str_mv | American Academy of Pediatrics (AAP), 2018 |
| institution | DE-Pl11, DE-82, DE-15, DE-Brt1, DE-D275, DE-Ch1, DE-Rs1, DE-Zwi2, DE-Bn3, DE-L229, DE-105, DE-D161, DE-Zi4, DE-14, DE-Gla1 |
| issn | 0031-4005, 1098-4275 |
| issn_str_mv | 0031-4005, 1098-4275 |
| language | English |
| last_indexed | 2023-02-23T21:11:03.773Z |
| match_str | newman2018childhoodseizuresafterphototherapy |
| mega_collection | American Academy of Pediatrics (AAP) (CrossRef) |
| physical | |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | American Academy of Pediatrics (AAP) |
| recordtype | ai |
| score | 18,660866 |
| series | Pediatrics |
| source_id | 49 |
| spelling | Newman, Thomas B. Wu, Yvonne W. Kuzniewicz, Michael W. Grimes, Barbara A. McCulloch, Charles E. 0031-4005 1098-4275 American Academy of Pediatrics (AAP) Pediatrics, Perinatology and Child Health http://dx.doi.org/10.1542/peds.2018-0648 <jats:sec> <jats:title /> </jats:sec> <jats:sec> <jats:title>BACKGROUND AND OBJECTIVES:</jats:title> <jats:p>In a recent Danish study, researchers found an increased risk of childhood epilepsy after phototherapy but only in boys. We investigated this association in a Kaiser Permanente Northern California cohort.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>From 499 642 infants born at ≥35 weeks’ gestation in 1995–2011 followed for ≥60 days, we excluded 1773 that exceeded exchange transfusion thresholds and 1237 with seizure diagnoses at &lt;60 days. We ascertained phototherapy, covariates, and outcomes from electronic records and existing databases. Our primary outcome was ≥1 encounter with a seizure diagnosis plus ≥1 prescription for an antiepileptic drug. We used Cox and Poisson models to adjust for bilirubin levels and other confounding variables.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p>A total of 37 683 (7.6%) infants received any phototherapy. The mean (SD) follow-up time was 8.1 (5.2) years. The crude incidence rate per 1000 person-years of the primary outcome was 1.24 among phototherapy-exposed children and 0.76 among those unexposed (rate ratio: 1.63; 95% confidence interval [CI]: 1.44 to 1.85). The adjusted hazard ratio (aHR) was 1.22 (95% CI: 1.05 to 1.42; P = .009). Boys were at higher risk of seizures overall (aHR = 1.18; 95% CI: 1.10 to 1.27) and had a higher aHR for phototherapy (1.33; 95% CI: 1.10 to 1.61) than girls (1.07; 95% CI: 0.84 to 1.37), although effect modification by sex was not statistically significant (P = .17). The adjusted 10-year excess risks per 1000 were 2.4 (95% CI: 0.6 to 4.1) overall, 3.7 (95% CI: 1.2 to 6.1) in boys, and 0.8 (95% CI: −1.7 to 3.2) in girls.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>Phototherapy in newborns is associated with a small increased risk of childhood seizures, even after adjusting for bilirubin values, and the risk is more significant in boys.</jats:p> </jats:sec> Childhood Seizures After Phototherapy Pediatrics |
| spellingShingle | Newman, Thomas B., Wu, Yvonne W., Kuzniewicz, Michael W., Grimes, Barbara A., McCulloch, Charles E., Pediatrics, Childhood Seizures After Phototherapy, Pediatrics, Perinatology and Child Health |
| title | Childhood Seizures After Phototherapy |
| title_full | Childhood Seizures After Phototherapy |
| title_fullStr | Childhood Seizures After Phototherapy |
| title_full_unstemmed | Childhood Seizures After Phototherapy |
| title_short | Childhood Seizures After Phototherapy |
| title_sort | childhood seizures after phototherapy |
| topic | Pediatrics, Perinatology and Child Health |
| url | http://dx.doi.org/10.1542/peds.2018-0648 |