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Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance
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| Zeitschriftentitel: | Canadian Journal of Microbiology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Canadian Journal of Microbiology, 64, 2018, 1, S. 87-90 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Canadian Science Publishing
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| Schlagwörter: |
| author_facet |
Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang |
|---|---|
| author |
Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang |
| spellingShingle |
Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang Canadian Journal of Microbiology Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance Genetics Molecular Biology Applied Microbiology and Biotechnology General Medicine Immunology Microbiology |
| author_sort |
zhong, chuanqing |
| spelling |
Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang 0008-4166 1480-3275 Canadian Science Publishing Genetics Molecular Biology Applied Microbiology and Biotechnology General Medicine Immunology Microbiology http://dx.doi.org/10.1139/cjm-2017-0475 <jats:p> Enterobacter cloacae strain R11 is a multidrug-resistant bacterium isolated from sewage water near a swine feedlot in China. Strain R11 can survive in medium containing up to 192 μg/mL polymyxin E, indicating a tolerance for this antibiotic that is significantly higher than that reported for other gram-negative bacteria. In this study, conjugation experiments showed that partial polymyxin E resistance could be transferred from strain R11 to Escherichia coli strain 25922, revealing that some genes related to polymyxin E resistance are plasmid-based. The complete genome sequence of this strain was determined, yielding a total of 4 993 008 bp (G+C content, 53.15%) and 4908 genes for the circular chromosome and 4 circular plasmids. Genome analysis revealed a total of 73 putative antibiotic resistance genes, including several polymyxin E resistance genes and genes potentially involved in multidrug resistance. These data provide insights into the genetic basis of the polymyxin E resistance and multidrug resistance of E. cloacae. </jats:p> Complete genome sequence of <i>Enterobacter cloacae</i> R11 reveals multiple genes potentially associated with high-level polymyxin E resistance Canadian Journal of Microbiology |
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| title |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_unstemmed |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_full |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_fullStr |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_full_unstemmed |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_short |
Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_sort |
complete genome sequence of <i>enterobacter cloacae</i> r11 reveals multiple genes potentially associated with high-level polymyxin e resistance |
| topic |
Genetics Molecular Biology Applied Microbiology and Biotechnology General Medicine Immunology Microbiology |
| url |
http://dx.doi.org/10.1139/cjm-2017-0475 |
| publishDate |
2018 |
| physical |
87-90 |
| description |
<jats:p> Enterobacter cloacae strain R11 is a multidrug-resistant bacterium isolated from sewage water near a swine feedlot in China. Strain R11 can survive in medium containing up to 192 μg/mL polymyxin E, indicating a tolerance for this antibiotic that is significantly higher than that reported for other gram-negative bacteria. In this study, conjugation experiments showed that partial polymyxin E resistance could be transferred from strain R11 to Escherichia coli strain 25922, revealing that some genes related to polymyxin E resistance are plasmid-based. The complete genome sequence of this strain was determined, yielding a total of 4 993 008 bp (G+C content, 53.15%) and 4908 genes for the circular chromosome and 4 circular plasmids. Genome analysis revealed a total of 73 putative antibiotic resistance genes, including several polymyxin E resistance genes and genes potentially involved in multidrug resistance. These data provide insights into the genetic basis of the polymyxin E resistance and multidrug resistance of E. cloacae. </jats:p> |
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| description | <jats:p> Enterobacter cloacae strain R11 is a multidrug-resistant bacterium isolated from sewage water near a swine feedlot in China. Strain R11 can survive in medium containing up to 192 μg/mL polymyxin E, indicating a tolerance for this antibiotic that is significantly higher than that reported for other gram-negative bacteria. In this study, conjugation experiments showed that partial polymyxin E resistance could be transferred from strain R11 to Escherichia coli strain 25922, revealing that some genes related to polymyxin E resistance are plasmid-based. The complete genome sequence of this strain was determined, yielding a total of 4 993 008 bp (G+C content, 53.15%) and 4908 genes for the circular chromosome and 4 circular plasmids. Genome analysis revealed a total of 73 putative antibiotic resistance genes, including several polymyxin E resistance genes and genes potentially involved in multidrug resistance. These data provide insights into the genetic basis of the polymyxin E resistance and multidrug resistance of E. cloacae. </jats:p> |
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| spelling | Zhong, Chuanqing Zhang, Chao Fu, Jiafang Chen, Wenbing Jiang, Tianyi Cao, Guangxiang 0008-4166 1480-3275 Canadian Science Publishing Genetics Molecular Biology Applied Microbiology and Biotechnology General Medicine Immunology Microbiology http://dx.doi.org/10.1139/cjm-2017-0475 <jats:p> Enterobacter cloacae strain R11 is a multidrug-resistant bacterium isolated from sewage water near a swine feedlot in China. Strain R11 can survive in medium containing up to 192 μg/mL polymyxin E, indicating a tolerance for this antibiotic that is significantly higher than that reported for other gram-negative bacteria. In this study, conjugation experiments showed that partial polymyxin E resistance could be transferred from strain R11 to Escherichia coli strain 25922, revealing that some genes related to polymyxin E resistance are plasmid-based. The complete genome sequence of this strain was determined, yielding a total of 4 993 008 bp (G+C content, 53.15%) and 4908 genes for the circular chromosome and 4 circular plasmids. Genome analysis revealed a total of 73 putative antibiotic resistance genes, including several polymyxin E resistance genes and genes potentially involved in multidrug resistance. These data provide insights into the genetic basis of the polymyxin E resistance and multidrug resistance of E. cloacae. </jats:p> Complete genome sequence of <i>Enterobacter cloacae</i> R11 reveals multiple genes potentially associated with high-level polymyxin E resistance Canadian Journal of Microbiology |
| spellingShingle | Zhong, Chuanqing, Zhang, Chao, Fu, Jiafang, Chen, Wenbing, Jiang, Tianyi, Cao, Guangxiang, Canadian Journal of Microbiology, Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance, Genetics, Molecular Biology, Applied Microbiology and Biotechnology, General Medicine, Immunology, Microbiology |
| title | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_full | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_fullStr | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_full_unstemmed | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_short | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| title_sort | complete genome sequence of <i>enterobacter cloacae</i> r11 reveals multiple genes potentially associated with high-level polymyxin e resistance |
| title_unstemmed | Complete genome sequence of Enterobacter cloacae R11 reveals multiple genes potentially associated with high-level polymyxin E resistance |
| topic | Genetics, Molecular Biology, Applied Microbiology and Biotechnology, General Medicine, Immunology, Microbiology |
| url | http://dx.doi.org/10.1139/cjm-2017-0475 |