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A New Benzofuran Derivative From the Stems of Helicteres hirsuta
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| Zeitschriftentitel: | Natural Product Communications |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Natural Product Communications, 14, 2019, 6, S. 1934578X1985881 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van |
|---|---|
| author |
Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van |
| spellingShingle |
Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van Natural Product Communications A New Benzofuran Derivative From the Stems of Helicteres hirsuta Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| author_sort |
tra, nguyen thanh |
| spelling |
Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19858814 <jats:p> A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC<jats:sub>50</jats:sub> values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta. </jats:p> A New Benzofuran Derivative From the Stems of <i>Helicteres hirsuta</i> Natural Product Communications |
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| title |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_unstemmed |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_full |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_fullStr |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_full_unstemmed |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_short |
A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_sort |
a new benzofuran derivative from the stems of <i>helicteres hirsuta</i> |
| topic |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| url |
http://dx.doi.org/10.1177/1934578x19858814 |
| publishDate |
2019 |
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1934578X1985881 |
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<jats:p> A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC<jats:sub>50</jats:sub> values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta. </jats:p> |
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| author | Tra, Nguyen Thanh, Ha, Nguyen Thi Thu, Cham, Ba Thi, Anh, Le Thi Tu, Yen, Le Thi Hai, Giang, Bach Long, Anh, Dang Thi Tuyet, Tuyen, Nguyen Van, Kiem, Phan Van |
| author_facet | Tra, Nguyen Thanh, Ha, Nguyen Thi Thu, Cham, Ba Thi, Anh, Le Thi Tu, Yen, Le Thi Hai, Giang, Bach Long, Anh, Dang Thi Tuyet, Tuyen, Nguyen Van, Kiem, Phan Van, Tra, Nguyen Thanh, Ha, Nguyen Thi Thu, Cham, Ba Thi, Anh, Le Thi Tu, Yen, Le Thi Hai, Giang, Bach Long, Anh, Dang Thi Tuyet, Tuyen, Nguyen Van, Kiem, Phan Van |
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| description | <jats:p> A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC<jats:sub>50</jats:sub> values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta. </jats:p> |
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| spelling | Tra, Nguyen Thanh Ha, Nguyen Thi Thu Cham, Ba Thi Anh, Le Thi Tu Yen, Le Thi Hai Giang, Bach Long Anh, Dang Thi Tuyet Tuyen, Nguyen Van Kiem, Phan Van 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19858814 <jats:p> A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC<jats:sub>50</jats:sub> values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta. </jats:p> A New Benzofuran Derivative From the Stems of <i>Helicteres hirsuta</i> Natural Product Communications |
| spellingShingle | Tra, Nguyen Thanh, Ha, Nguyen Thi Thu, Cham, Ba Thi, Anh, Le Thi Tu, Yen, Le Thi Hai, Giang, Bach Long, Anh, Dang Thi Tuyet, Tuyen, Nguyen Van, Kiem, Phan Van, Natural Product Communications, A New Benzofuran Derivative From the Stems of Helicteres hirsuta, Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| title | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_full | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_fullStr | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_full_unstemmed | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_short | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| title_sort | a new benzofuran derivative from the stems of <i>helicteres hirsuta</i> |
| title_unstemmed | A New Benzofuran Derivative From the Stems of Helicteres hirsuta |
| topic | Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| url | http://dx.doi.org/10.1177/1934578x19858814 |