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Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis
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| Zeitschriftentitel: | Therapeutic Advances in Musculoskeletal Disease |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Therapeutic Advances in Musculoskeletal Disease, 11, 2019, S. 1759720X1986361 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas |
|---|---|
| author |
Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas |
| spellingShingle |
Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas Therapeutic Advances in Musculoskeletal Disease Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis Orthopedics and Sports Medicine Rheumatology |
| author_sort |
durchschein, franziska |
| spelling |
Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas 1759-720X 1759-7218 SAGE Publications Orthopedics and Sports Medicine Rheumatology http://dx.doi.org/10.1177/1759720x19863618 <jats:sec><jats:title>Background:</jats:title><jats:p> Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurred, as one patient developed multiple cerebellar embolic infarcts. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Because of the favorable effect in all patients, a safe route for esophageal fat injection needs to be developed. </jats:p></jats:sec> Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis Therapeutic Advances in Musculoskeletal Disease |
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SAGE Publications, 2019 |
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SAGE Publications, 2019 |
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Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_unstemmed |
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_full |
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_fullStr |
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_full_unstemmed |
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_short |
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_sort |
helpful, albeit hazardous! esophageal stem-cell injection in systemic sclerosis |
| topic |
Orthopedics and Sports Medicine Rheumatology |
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http://dx.doi.org/10.1177/1759720x19863618 |
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2019 |
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1759720X1986361 |
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<jats:sec><jats:title>Background:</jats:title><jats:p> Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurred, as one patient developed multiple cerebellar embolic infarcts. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Because of the favorable effect in all patients, a safe route for esophageal fat injection needs to be developed. </jats:p></jats:sec> |
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| author | Durchschein, Franziska, Moazedi-Fuerst, Florentine, Kielhauser, Sonja, Lackner, Angelika, Wiedner, Maria, Koch, Horst, Justich, Ivo, Eherer, Andreas |
| author_facet | Durchschein, Franziska, Moazedi-Fuerst, Florentine, Kielhauser, Sonja, Lackner, Angelika, Wiedner, Maria, Koch, Horst, Justich, Ivo, Eherer, Andreas, Durchschein, Franziska, Moazedi-Fuerst, Florentine, Kielhauser, Sonja, Lackner, Angelika, Wiedner, Maria, Koch, Horst, Justich, Ivo, Eherer, Andreas |
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| description | <jats:sec><jats:title>Background:</jats:title><jats:p> Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurred, as one patient developed multiple cerebellar embolic infarcts. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Because of the favorable effect in all patients, a safe route for esophageal fat injection needs to be developed. </jats:p></jats:sec> |
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| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | Durchschein, Franziska Moazedi-Fuerst, Florentine Kielhauser, Sonja Lackner, Angelika Wiedner, Maria Koch, Horst Justich, Ivo Eherer, Andreas 1759-720X 1759-7218 SAGE Publications Orthopedics and Sports Medicine Rheumatology http://dx.doi.org/10.1177/1759720x19863618 <jats:sec><jats:title>Background:</jats:title><jats:p> Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurred, as one patient developed multiple cerebellar embolic infarcts. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Because of the favorable effect in all patients, a safe route for esophageal fat injection needs to be developed. </jats:p></jats:sec> Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis Therapeutic Advances in Musculoskeletal Disease |
| spellingShingle | Durchschein, Franziska, Moazedi-Fuerst, Florentine, Kielhauser, Sonja, Lackner, Angelika, Wiedner, Maria, Koch, Horst, Justich, Ivo, Eherer, Andreas, Therapeutic Advances in Musculoskeletal Disease, Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis, Orthopedics and Sports Medicine, Rheumatology |
| title | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_full | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_fullStr | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_full_unstemmed | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_short | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| title_sort | helpful, albeit hazardous! esophageal stem-cell injection in systemic sclerosis |
| title_unstemmed | Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis |
| topic | Orthopedics and Sports Medicine, Rheumatology |
| url | http://dx.doi.org/10.1177/1759720x19863618 |