author_facet Bank, Alan J
Kelly, Aaron S
Kaiser, Daniel R
Crawford, William W
Waxman, Benjamin
Schow, Douglas A
Billups, Kevin L
Bank, Alan J
Kelly, Aaron S
Kaiser, Daniel R
Crawford, William W
Waxman, Benjamin
Schow, Douglas A
Billups, Kevin L
author Bank, Alan J
Kelly, Aaron S
Kaiser, Daniel R
Crawford, William W
Waxman, Benjamin
Schow, Douglas A
Billups, Kevin L
spellingShingle Bank, Alan J
Kelly, Aaron S
Kaiser, Daniel R
Crawford, William W
Waxman, Benjamin
Schow, Douglas A
Billups, Kevin L
Vascular Medicine
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
Cardiology and Cardiovascular Medicine
author_sort bank, alan j
spelling Bank, Alan J Kelly, Aaron S Kaiser, Daniel R Crawford, William W Waxman, Benjamin Schow, Douglas A Billups, Kevin L 1358-863X 1477-0377 SAGE Publications Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1177/1358863x06072221 <jats:p> Phosphodiesterase-5 (PDE-5) inhibitors are an effective therapy for the majority of men with erectile dysfunction (ED). However, many men with ED still report a suboptimal or partial response even after an adequate trial of oral PDE-5 therapy. Since ED is associated with impaired vascular function and both atorvastatin and quinapril have been previously shown to improve vascular function, we examined the effects of adjunctive treatment with these medications in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Men with ED and suboptimal response to sildenafil were randomly assigned to 3 months of treatment with atorvastatin 40 mg ( n = 12), quinapril 10 mg ( n = 10), or placebo ( n = 13), along with continued adjunctive sildenafil use. Measured variables included: International Index of Erectile Function (IIEF) questionnaire, brachial artery flow-mediated dilation (FMD), endothelium-independent dilation (EID) via nitroglycerin, penile Doppler blood flow, blood pressure (BP), lipids, and C-reactive protein (CRP). Compared to placebo, quinapril ( p &lt; 0.01) significantly improved symptoms of ED as measured by the IIEF-5 questionnaire. There was a trend toward a significant improvement in IIEF-5 with atorvastatin. Similarly, quinapril significantly improved the IIEF ED Domain ( p &lt; 0.05). Other peripheral and penile vascular parameters were unchanged with drug therapy as compared to placebo. In conclusion, treatment with quinapril, in combination with sildenafil, improved ED in men with suboptimal response to sildenafil alone. Atorvastatin demonstrated a trend toward improved ED in this group. </jats:p> The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction Vascular Medicine
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title The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_unstemmed The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_full The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_fullStr The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_full_unstemmed The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_short The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_sort the effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
topic Cardiology and Cardiovascular Medicine
url http://dx.doi.org/10.1177/1358863x06072221
publishDate 2006
physical 251-257
description <jats:p> Phosphodiesterase-5 (PDE-5) inhibitors are an effective therapy for the majority of men with erectile dysfunction (ED). However, many men with ED still report a suboptimal or partial response even after an adequate trial of oral PDE-5 therapy. Since ED is associated with impaired vascular function and both atorvastatin and quinapril have been previously shown to improve vascular function, we examined the effects of adjunctive treatment with these medications in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Men with ED and suboptimal response to sildenafil were randomly assigned to 3 months of treatment with atorvastatin 40 mg ( n = 12), quinapril 10 mg ( n = 10), or placebo ( n = 13), along with continued adjunctive sildenafil use. Measured variables included: International Index of Erectile Function (IIEF) questionnaire, brachial artery flow-mediated dilation (FMD), endothelium-independent dilation (EID) via nitroglycerin, penile Doppler blood flow, blood pressure (BP), lipids, and C-reactive protein (CRP). Compared to placebo, quinapril ( p &lt; 0.01) significantly improved symptoms of ED as measured by the IIEF-5 questionnaire. There was a trend toward a significant improvement in IIEF-5 with atorvastatin. Similarly, quinapril significantly improved the IIEF ED Domain ( p &lt; 0.05). Other peripheral and penile vascular parameters were unchanged with drug therapy as compared to placebo. In conclusion, treatment with quinapril, in combination with sildenafil, improved ED in men with suboptimal response to sildenafil alone. Atorvastatin demonstrated a trend toward improved ED in this group. </jats:p>
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author Bank, Alan J, Kelly, Aaron S, Kaiser, Daniel R, Crawford, William W, Waxman, Benjamin, Schow, Douglas A, Billups, Kevin L
author_facet Bank, Alan J, Kelly, Aaron S, Kaiser, Daniel R, Crawford, William W, Waxman, Benjamin, Schow, Douglas A, Billups, Kevin L, Bank, Alan J, Kelly, Aaron S, Kaiser, Daniel R, Crawford, William W, Waxman, Benjamin, Schow, Douglas A, Billups, Kevin L
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description <jats:p> Phosphodiesterase-5 (PDE-5) inhibitors are an effective therapy for the majority of men with erectile dysfunction (ED). However, many men with ED still report a suboptimal or partial response even after an adequate trial of oral PDE-5 therapy. Since ED is associated with impaired vascular function and both atorvastatin and quinapril have been previously shown to improve vascular function, we examined the effects of adjunctive treatment with these medications in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Men with ED and suboptimal response to sildenafil were randomly assigned to 3 months of treatment with atorvastatin 40 mg ( n = 12), quinapril 10 mg ( n = 10), or placebo ( n = 13), along with continued adjunctive sildenafil use. Measured variables included: International Index of Erectile Function (IIEF) questionnaire, brachial artery flow-mediated dilation (FMD), endothelium-independent dilation (EID) via nitroglycerin, penile Doppler blood flow, blood pressure (BP), lipids, and C-reactive protein (CRP). Compared to placebo, quinapril ( p &lt; 0.01) significantly improved symptoms of ED as measured by the IIEF-5 questionnaire. There was a trend toward a significant improvement in IIEF-5 with atorvastatin. Similarly, quinapril significantly improved the IIEF ED Domain ( p &lt; 0.05). Other peripheral and penile vascular parameters were unchanged with drug therapy as compared to placebo. In conclusion, treatment with quinapril, in combination with sildenafil, improved ED in men with suboptimal response to sildenafil alone. Atorvastatin demonstrated a trend toward improved ED in this group. </jats:p>
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spelling Bank, Alan J Kelly, Aaron S Kaiser, Daniel R Crawford, William W Waxman, Benjamin Schow, Douglas A Billups, Kevin L 1358-863X 1477-0377 SAGE Publications Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1177/1358863x06072221 <jats:p> Phosphodiesterase-5 (PDE-5) inhibitors are an effective therapy for the majority of men with erectile dysfunction (ED). However, many men with ED still report a suboptimal or partial response even after an adequate trial of oral PDE-5 therapy. Since ED is associated with impaired vascular function and both atorvastatin and quinapril have been previously shown to improve vascular function, we examined the effects of adjunctive treatment with these medications in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Men with ED and suboptimal response to sildenafil were randomly assigned to 3 months of treatment with atorvastatin 40 mg ( n = 12), quinapril 10 mg ( n = 10), or placebo ( n = 13), along with continued adjunctive sildenafil use. Measured variables included: International Index of Erectile Function (IIEF) questionnaire, brachial artery flow-mediated dilation (FMD), endothelium-independent dilation (EID) via nitroglycerin, penile Doppler blood flow, blood pressure (BP), lipids, and C-reactive protein (CRP). Compared to placebo, quinapril ( p &lt; 0.01) significantly improved symptoms of ED as measured by the IIEF-5 questionnaire. There was a trend toward a significant improvement in IIEF-5 with atorvastatin. Similarly, quinapril significantly improved the IIEF ED Domain ( p &lt; 0.05). Other peripheral and penile vascular parameters were unchanged with drug therapy as compared to placebo. In conclusion, treatment with quinapril, in combination with sildenafil, improved ED in men with suboptimal response to sildenafil alone. Atorvastatin demonstrated a trend toward improved ED in this group. </jats:p> The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction Vascular Medicine
spellingShingle Bank, Alan J, Kelly, Aaron S, Kaiser, Daniel R, Crawford, William W, Waxman, Benjamin, Schow, Douglas A, Billups, Kevin L, Vascular Medicine, The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction, Cardiology and Cardiovascular Medicine
title The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_full The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_fullStr The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_full_unstemmed The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_short The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_sort the effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
title_unstemmed The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
topic Cardiology and Cardiovascular Medicine
url http://dx.doi.org/10.1177/1358863x06072221