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Galanin expression is down-regulated in patients with gastric cancer
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| Zeitschriftentitel: | Journal of International Medical Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Journal of International Medical Research, 47, 2019, 3, S. 1241-1249 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping |
|---|---|
| author |
Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping |
| spellingShingle |
Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping Journal of International Medical Research Galanin expression is down-regulated in patients with gastric cancer Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| author_sort |
zhang, lei |
| spelling |
Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518819382 <jats:sec><jats:title>Objective</jats:title><jats:p> To investigate whether galanin and its three receptors (Gal-R1, Gal-R2, Gal-R3) contribute to development of gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Preoperative and postoperative fasting venous blood samples were collected from 34 patients with gastric cancer and 13 healthy individuals. Plasma galanin contents, as well as expression levels of galanin and its receptors, were quantitatively examined in a cohort of human gastric cancer tissues and corresponding adjacent tissues. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Statistically significantly lower galanin levels were found in the preoperative samples from patients with gastric cancer, compared with postoperative samples from these same patients, as well as with samples from healthy donors. Furthermore, galanin and Gal-R1 expression levels were dramatically reduced in gastric cancer tissues, compared with corresponding adjacent tissues, whereas Gal-R2 and Gal-R3 levels remained unchanged. Furthermore, galanin mRNA and protein expression levels in the preoperative samples from patients with gastric cancer were significantly correlated with lymph node metastasis, tumor node metastasis stage, and size of the gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Overall levels of galanin and Gal-R1 expression were down-regulated in patients with gastric cancer; local levels were also specifically downregulated in gastric cancer tissues. Galanin and its receptor, Gal-R1, may contribute to development of gastric cancer. </jats:p></jats:sec> Galanin expression is down-regulated in patients with gastric cancer Journal of International Medical Research |
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SAGE Publications, 2019 |
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SAGE Publications, 2019 |
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| title |
Galanin expression is down-regulated in patients with gastric cancer |
| title_unstemmed |
Galanin expression is down-regulated in patients with gastric cancer |
| title_full |
Galanin expression is down-regulated in patients with gastric cancer |
| title_fullStr |
Galanin expression is down-regulated in patients with gastric cancer |
| title_full_unstemmed |
Galanin expression is down-regulated in patients with gastric cancer |
| title_short |
Galanin expression is down-regulated in patients with gastric cancer |
| title_sort |
galanin expression is down-regulated in patients with gastric cancer |
| topic |
Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| url |
http://dx.doi.org/10.1177/0300060518819382 |
| publishDate |
2019 |
| physical |
1241-1249 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p> To investigate whether galanin and its three receptors (Gal-R1, Gal-R2, Gal-R3) contribute to development of gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Preoperative and postoperative fasting venous blood samples were collected from 34 patients with gastric cancer and 13 healthy individuals. Plasma galanin contents, as well as expression levels of galanin and its receptors, were quantitatively examined in a cohort of human gastric cancer tissues and corresponding adjacent tissues. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Statistically significantly lower galanin levels were found in the preoperative samples from patients with gastric cancer, compared with postoperative samples from these same patients, as well as with samples from healthy donors. Furthermore, galanin and Gal-R1 expression levels were dramatically reduced in gastric cancer tissues, compared with corresponding adjacent tissues, whereas Gal-R2 and Gal-R3 levels remained unchanged. Furthermore, galanin mRNA and protein expression levels in the preoperative samples from patients with gastric cancer were significantly correlated with lymph node metastasis, tumor node metastasis stage, and size of the gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Overall levels of galanin and Gal-R1 expression were down-regulated in patients with gastric cancer; local levels were also specifically downregulated in gastric cancer tissues. Galanin and its receptor, Gal-R1, may contribute to development of gastric cancer. </jats:p></jats:sec> |
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| author | Zhang, Lei, Fang, Penghua, Chai, Chenghua, Shao, Lijuan, Mao, Haiyan, Qiao, Dawei, Kong, Guimei, Dong, Xiaoyun, Shi, Mingyi, Zhang, Zhenwen, Bo, Ping |
| author_facet | Zhang, Lei, Fang, Penghua, Chai, Chenghua, Shao, Lijuan, Mao, Haiyan, Qiao, Dawei, Kong, Guimei, Dong, Xiaoyun, Shi, Mingyi, Zhang, Zhenwen, Bo, Ping, Zhang, Lei, Fang, Penghua, Chai, Chenghua, Shao, Lijuan, Mao, Haiyan, Qiao, Dawei, Kong, Guimei, Dong, Xiaoyun, Shi, Mingyi, Zhang, Zhenwen, Bo, Ping |
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| description | <jats:sec><jats:title>Objective</jats:title><jats:p> To investigate whether galanin and its three receptors (Gal-R1, Gal-R2, Gal-R3) contribute to development of gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Preoperative and postoperative fasting venous blood samples were collected from 34 patients with gastric cancer and 13 healthy individuals. Plasma galanin contents, as well as expression levels of galanin and its receptors, were quantitatively examined in a cohort of human gastric cancer tissues and corresponding adjacent tissues. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Statistically significantly lower galanin levels were found in the preoperative samples from patients with gastric cancer, compared with postoperative samples from these same patients, as well as with samples from healthy donors. Furthermore, galanin and Gal-R1 expression levels were dramatically reduced in gastric cancer tissues, compared with corresponding adjacent tissues, whereas Gal-R2 and Gal-R3 levels remained unchanged. Furthermore, galanin mRNA and protein expression levels in the preoperative samples from patients with gastric cancer were significantly correlated with lymph node metastasis, tumor node metastasis stage, and size of the gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Overall levels of galanin and Gal-R1 expression were down-regulated in patients with gastric cancer; local levels were also specifically downregulated in gastric cancer tissues. Galanin and its receptor, Gal-R1, may contribute to development of gastric cancer. </jats:p></jats:sec> |
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| spelling | Zhang, Lei Fang, Penghua Chai, Chenghua Shao, Lijuan Mao, Haiyan Qiao, Dawei Kong, Guimei Dong, Xiaoyun Shi, Mingyi Zhang, Zhenwen Bo, Ping 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518819382 <jats:sec><jats:title>Objective</jats:title><jats:p> To investigate whether galanin and its three receptors (Gal-R1, Gal-R2, Gal-R3) contribute to development of gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Preoperative and postoperative fasting venous blood samples were collected from 34 patients with gastric cancer and 13 healthy individuals. Plasma galanin contents, as well as expression levels of galanin and its receptors, were quantitatively examined in a cohort of human gastric cancer tissues and corresponding adjacent tissues. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Statistically significantly lower galanin levels were found in the preoperative samples from patients with gastric cancer, compared with postoperative samples from these same patients, as well as with samples from healthy donors. Furthermore, galanin and Gal-R1 expression levels were dramatically reduced in gastric cancer tissues, compared with corresponding adjacent tissues, whereas Gal-R2 and Gal-R3 levels remained unchanged. Furthermore, galanin mRNA and protein expression levels in the preoperative samples from patients with gastric cancer were significantly correlated with lymph node metastasis, tumor node metastasis stage, and size of the gastric cancer. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Overall levels of galanin and Gal-R1 expression were down-regulated in patients with gastric cancer; local levels were also specifically downregulated in gastric cancer tissues. Galanin and its receptor, Gal-R1, may contribute to development of gastric cancer. </jats:p></jats:sec> Galanin expression is down-regulated in patients with gastric cancer Journal of International Medical Research |
| spellingShingle | Zhang, Lei, Fang, Penghua, Chai, Chenghua, Shao, Lijuan, Mao, Haiyan, Qiao, Dawei, Kong, Guimei, Dong, Xiaoyun, Shi, Mingyi, Zhang, Zhenwen, Bo, Ping, Journal of International Medical Research, Galanin expression is down-regulated in patients with gastric cancer, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| title | Galanin expression is down-regulated in patients with gastric cancer |
| title_full | Galanin expression is down-regulated in patients with gastric cancer |
| title_fullStr | Galanin expression is down-regulated in patients with gastric cancer |
| title_full_unstemmed | Galanin expression is down-regulated in patients with gastric cancer |
| title_short | Galanin expression is down-regulated in patients with gastric cancer |
| title_sort | galanin expression is down-regulated in patients with gastric cancer |
| title_unstemmed | Galanin expression is down-regulated in patients with gastric cancer |
| topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1177/0300060518819382 |