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RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice
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Zeitschriftentitel: | American Journal of Physiology-Gastrointestinal and Liver Physiology |
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Personen und Körperschaften: | , , , , |
In: | American Journal of Physiology-Gastrointestinal and Liver Physiology, 307, 2014, 3, S. G330-G337 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Physiological Society
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Schlagwörter: |
author_facet |
Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas |
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author |
Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas |
spellingShingle |
Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas American Journal of Physiology-Gastrointestinal and Liver Physiology RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice Physiology (medical) Gastroenterology Hepatology Physiology |
author_sort |
pais, ramona |
spelling |
Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00329.2013 <jats:p>Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic β-cells and protects from β-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.</jats:p> RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice American Journal of Physiology-Gastrointestinal and Liver Physiology |
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10.1152/ajpgi.00329.2013 |
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Biologie Medizin |
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American Physiological Society, 2014 |
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American Physiological Society |
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American Journal of Physiology-Gastrointestinal and Liver Physiology |
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title |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_unstemmed |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_full |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_fullStr |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_full_unstemmed |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_short |
RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_sort |
rantes (ccl5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
topic |
Physiology (medical) Gastroenterology Hepatology Physiology |
url |
http://dx.doi.org/10.1152/ajpgi.00329.2013 |
publishDate |
2014 |
physical |
G330-G337 |
description |
<jats:p>Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic β-cells and protects from β-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.</jats:p> |
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American Journal of Physiology-Gastrointestinal and Liver Physiology |
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author | Pais, Ramona, Zietek, Tamara, Hauner, Hans, Daniel, Hannelore, Skurk, Thomas |
author_facet | Pais, Ramona, Zietek, Tamara, Hauner, Hans, Daniel, Hannelore, Skurk, Thomas, Pais, Ramona, Zietek, Tamara, Hauner, Hans, Daniel, Hannelore, Skurk, Thomas |
author_sort | pais, ramona |
container_issue | 3 |
container_start_page | 0 |
container_title | American Journal of Physiology-Gastrointestinal and Liver Physiology |
container_volume | 307 |
description | <jats:p>Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic β-cells and protects from β-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.</jats:p> |
doi_str_mv | 10.1152/ajpgi.00329.2013 |
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imprint | American Physiological Society, 2014 |
imprint_str_mv | American Physiological Society, 2014 |
institution | DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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physical | G330-G337 |
publishDate | 2014 |
publishDateSort | 2014 |
publisher | American Physiological Society |
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series | American Journal of Physiology-Gastrointestinal and Liver Physiology |
source_id | 49 |
spelling | Pais, Ramona Zietek, Tamara Hauner, Hans Daniel, Hannelore Skurk, Thomas 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00329.2013 <jats:p>Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic β-cells and protects from β-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.</jats:p> RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice American Journal of Physiology-Gastrointestinal and Liver Physiology |
spellingShingle | Pais, Ramona, Zietek, Tamara, Hauner, Hans, Daniel, Hannelore, Skurk, Thomas, American Journal of Physiology-Gastrointestinal and Liver Physiology, RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice, Physiology (medical), Gastroenterology, Hepatology, Physiology |
title | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_full | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_fullStr | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_full_unstemmed | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_short | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_sort | rantes (ccl5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
title_unstemmed | RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice |
topic | Physiology (medical), Gastroenterology, Hepatology, Physiology |
url | http://dx.doi.org/10.1152/ajpgi.00329.2013 |