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Determinants of postprandial plasma bile acid kinetics in human volunteers
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| Zeitschriftentitel: | American Journal of Physiology-Gastrointestinal and Liver Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , |
| In: | American Journal of Physiology-Gastrointestinal and Liver Physiology, 313, 2017, 4, S. G300-G312 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
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| Schlagwörter: |
| author_facet |
Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore |
|---|---|
| author |
Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore |
| spellingShingle |
Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore American Journal of Physiology-Gastrointestinal and Liver Physiology Determinants of postprandial plasma bile acid kinetics in human volunteers Physiology (medical) Gastroenterology Hepatology Physiology |
| author_sort |
fiamoncini, jarlei |
| spelling |
Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00157.2017 <jats:p>Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.</jats:p><jats:p>NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.</jats:p> Determinants of postprandial plasma bile acid kinetics in human volunteers American Journal of Physiology-Gastrointestinal and Liver Physiology |
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| title |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_unstemmed |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_full |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_fullStr |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_full_unstemmed |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_short |
Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_sort |
determinants of postprandial plasma bile acid kinetics in human volunteers |
| topic |
Physiology (medical) Gastroenterology Hepatology Physiology |
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http://dx.doi.org/10.1152/ajpgi.00157.2017 |
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2017 |
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G300-G312 |
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<jats:p>Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.</jats:p><jats:p>NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.</jats:p> |
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| author | Fiamoncini, Jarlei, Yiorkas, Andrianos M., Gedrich, Kurt, Rundle, Milena, Alsters, Sanne I., Roeselers, Guus, van den Broek, Tim J., Clavel, Thomas, Lagkouvardos, Ilias, Wopereis, Suzan, Frost, Gary, van Ommen, Ben, Blakemore, Alexandra I., Daniel, Hannelore |
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| description | <jats:p>Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.</jats:p><jats:p>NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.</jats:p> |
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| spelling | Fiamoncini, Jarlei Yiorkas, Andrianos M. Gedrich, Kurt Rundle, Milena Alsters, Sanne I. Roeselers, Guus van den Broek, Tim J. Clavel, Thomas Lagkouvardos, Ilias Wopereis, Suzan Frost, Gary van Ommen, Ben Blakemore, Alexandra I. Daniel, Hannelore 0193-1857 1522-1547 American Physiological Society Physiology (medical) Gastroenterology Hepatology Physiology http://dx.doi.org/10.1152/ajpgi.00157.2017 <jats:p>Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women ( n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention. BA were quantified in plasma by liquid chromatography-tandem mass spectrometry combined with whole genome exome sequencing and fecal microbiota profiling. Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma BA profiles. Fasting and postprandial BA profiles revealed high interindividual variability, and three main patterns in postprandial BA response were identified using multivariate analysis. Although the women enrolled were postmenopausal, effects of sex difference in BA response were evident. Exome data revealed the contribution of preselected genes to the observed interindividual variability. In particular, a variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases. Fecal microbiota analysis did not reveal evidence for a significant influence of bacterial diversity and/or composition on plasma BA profiles. The analysis of plasma BA profiles in response to two different dietary challenges revealed a high interindividual variability, which was mainly determined by genetics and sex difference of host with minimal effects of the microbiota.</jats:p><jats:p>NEW & NOTEWORTHY Considering the average response of all 72 subjects, no effect of the successful weight loss intervention was found on plasma bile acid (BA) profiles. Despite high interindividual variability, three main patterns in postprandial BA response were identified using multivariate analysis. A variant in the SLCO1A2 gene, encoding the small intestinal BA transporter organic anion-transporting polypeptide-1A2 (OATP1A2), was associated with delayed postprandial BA increases in response to both the oral glucose tolerance test and the mixed-meal tolerance test.</jats:p> Determinants of postprandial plasma bile acid kinetics in human volunteers American Journal of Physiology-Gastrointestinal and Liver Physiology |
| spellingShingle | Fiamoncini, Jarlei, Yiorkas, Andrianos M., Gedrich, Kurt, Rundle, Milena, Alsters, Sanne I., Roeselers, Guus, van den Broek, Tim J., Clavel, Thomas, Lagkouvardos, Ilias, Wopereis, Suzan, Frost, Gary, van Ommen, Ben, Blakemore, Alexandra I., Daniel, Hannelore, American Journal of Physiology-Gastrointestinal and Liver Physiology, Determinants of postprandial plasma bile acid kinetics in human volunteers, Physiology (medical), Gastroenterology, Hepatology, Physiology |
| title | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_full | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_fullStr | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_full_unstemmed | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_short | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_sort | determinants of postprandial plasma bile acid kinetics in human volunteers |
| title_unstemmed | Determinants of postprandial plasma bile acid kinetics in human volunteers |
| topic | Physiology (medical), Gastroenterology, Hepatology, Physiology |
| url | http://dx.doi.org/10.1152/ajpgi.00157.2017 |